Glucokinase. Single chain protein binds to no of cofactors like ATP and others apart from it's substrate glucose.
Thanks Zeya On Fri, 20 Dec, 2024, 2:48 pm Harry Powell, < 0000193323b1e616-dmarc-requ...@jiscmail.ac.uk> wrote: > Wow. I was right about one thing - this _is_ a good place to ask. > > Many thanks for the flood of responses - that will keep me busy for a > while - I’ll get back to you with what I think are the most useful ones for > my purposes (so many, many apologies to those people who have taken the > time to respond but came up with suggestions that didn’t "hit the spot" for > some reason!). > > Just for the record, I’m not interested in any co-factors like water or > “isolated” metal ions (so not part of a bigger assembly - I’m interested in > things like haem, for example, but not things like hexaaquacobalt). So > anything that has (say) FAD and ADP bound by the same chain would pique my > interest - especially if both are listed in the corresponding UniProt KB > entry (just because a PDB entry has more than one ligand bound, they may > not both really be cofactors…). If UniProt KB tells me that there’s only > one cofactor (or worse, none), then I will rapidly move on (unless someone > can provide a solid justification as to why UniProt is wrong and they’re > right…). > > Enjoy a solstice-oriented break! > > best wishes > > Harry > > > On 20 Dec 2024, at 10:37, Harry Powell < > 0000193323b1e616-dmarc-requ...@jiscmail.ac.uk> wrote: > > > > Hi folks > > > > I’m familiar with enzymes that have a single co-factor (for example haem > in myoglobin [or in the individual chains in haemoglobins] or FAD in > flavoproteins), but was wondering if there are examples of single-chain > proteins that have multiple cofactors (or even multiple chain proteins that > have multiple cofactors bound to a single chain)? > > > > I’m not bothered (at the moment) about proteins that have cofactors > bound to different chains. > > > > I thought this would be a good place to ask… > > > > Harry > > ######################################################################## > > > > To unsubscribe from the CCP4BB list, click the following link: > > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a > mailing list hosted by www.jiscmail.ac.uk, terms & conditions are > available at https://www.jiscmail.ac.uk/policyandsecurity/ > > ######################################################################## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a > mailing list hosted by www.jiscmail.ac.uk, terms & conditions are > available at https://www.jiscmail.ac.uk/policyandsecurity/ > ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
