Yes, multiple cofactors can exist in active sites. One example is Enolase. Also, metal-metal bonds are common in coordination spheres for catalysis.
On Fri, Dec 20, 2024 at 4:34 PM David Briggs <david.bri...@crick.ac.uk> wrote: > Hi Harry, > > The first thing that comes to mind is any sort of light harvesting complex > - take a look at 1RWT. Would that fit the bill? > > D > > > > -- > > *Dr David C. Briggs CSci MRSB **(he/him)* > > Principal Laboratory Research Scientist > > Signalling and Structural Biology Lab > > The Francis Crick Institute > > London, UK > > *Working hours: Mon-Fri 0900-1700* > > == > > about.me/david_briggs | OrcID <https://orcid.org/0000-0002-9793-7339> | Google > Scholar <https://scholar.google.co.uk/citations?user=DRKG5KwAAAAJ> > > == > > "Would it not be better if one could really 'see' whether molecules...were > just as experiments suggested?" > > – Dorothy Hodgkin > ------------------------------ > *From:* CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of Harry > Powell <0000193323b1e616-dmarc-requ...@jiscmail.ac.uk> > *Sent:* 20 December 2024 10:37 > *To:* CCP4BB@JISCMAIL.AC.UK <CCP4BB@JISCMAIL.AC.UK> > *Subject:* [ccp4bb] enzyme or other protein with multiple cofactors > > > External Sender: Use caution. > > > Hi folks > > I’m familiar with enzymes that have a single co-factor (for example haem > in myoglobin [or in the individual chains in haemoglobins] or FAD in > flavoproteins), but was wondering if there are examples of single-chain > proteins that have multiple cofactors (or even multiple chain proteins that > have multiple cofactors bound to a single chain)? > > I’m not bothered (at the moment) about proteins that have cofactors bound > to different chains. > > I thought this would be a good place to ask… > > Harry > ######################################################################## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a > mailing list hosted by www.jiscmail.ac.uk, terms & conditions are > available at https://www.jiscmail.ac.uk/policyandsecurity/ > > The Francis Crick Institute Limited is a registered charity in England and > Wales no. 1140062 and a company registered in England and Wales no. > 06885462, with its registered office at 1 Midland Road London NW1 1AT > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
