Hi Harry,

PDB 1QLB is 2.33A and has protoporphyrin, FAD and Fe-S clusters bound…

https://www.rcsb.org/structure/1QLB
respiratory complex II-like fumarate reductase from Wolinella succinogenes

Cheers, Charlie.

From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> On Behalf Of Harry Powell
Sent: Friday, December 20, 2024 10:38 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] enzyme or other protein with multiple cofactors

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Hi folks

I’m familiar with enzymes that have a single co-factor (for example haem in 
myoglobin [or in the individual chains in haemoglobins] or FAD in 
flavoproteins), but was wondering if there are examples of single-chain 
proteins that have multiple cofactors (or even multiple chain proteins that 
have multiple cofactors bound to a single chain)?

I’m not bothered (at the moment) about proteins that have cofactors bound to 
different chains.

I thought this would be a good place to ask…

Harry
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