Dear Harry,
You can check this structure of an FAD-dependent monooxygenase with
bound FAD and NADPH: https://www.rcsb.org/structure/1k0j
However, authors of this review (https://doi.org/10.3390/ijms131215601)
seem not to be convinced about the NADPH position (if I remember that
review right).
By the way, I would be interested in metal-metal interactions in
biomolecules (if I can a bit hijack this thread...) I do not mean
interactions like Mg-Cl-Mg, but clearly two metal atoms closer than ~3.6
A to each other.
Best wishes,
Martin
On 20/12/2024 11:07, Chandra Prakash Tiwari wrote:
Yes, multiple cofactors can exist in active sites. One example is
Enolase. Also, metal-metal bonds are common in coordination spheres
for catalysis.
On Fri, Dec 20, 2024 at 4:34 PM David Briggs
<david.bri...@crick.ac.uk> wrote:
Hi Harry,
The first thing that comes to mind is any sort of light harvesting
complex - take a look at 1RWT. Would that fit the bill?
D
--
*Dr David C. Briggs CSci MRSB */(he/him)/
Principal Laboratory Research Scientist
Signalling and Structural Biology Lab
The Francis Crick Institute
London, UK
/Working hours: Mon-Fri 0900-1700/
==
about.me/david_briggs <https://about.me/david_briggs> | OrcID
<https://orcid.org/0000-0002-9793-7339> | Google Scholar
<https://scholar.google.co.uk/citations?user=DRKG5KwAAAAJ>
==
"Would it not be better if one could really 'see' whether
molecules...were just as experiments suggested?"
– Dorothy Hodgkin
------------------------------------------------------------------------
*From:* CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of
Harry Powell <0000193323b1e616-dmarc-requ...@jiscmail.ac.uk>
*Sent:* 20 December 2024 10:37
*To:* CCP4BB@JISCMAIL.AC.UK <CCP4BB@JISCMAIL.AC.UK>
*Subject:* [ccp4bb] enzyme or other protein with multiple cofactors
External Sender: Use caution.
Hi folks
I’m familiar with enzymes that have a single co-factor (for
example haem in myoglobin [or in the individual chains in
haemoglobins] or FAD in flavoproteins), but was wondering if there
are examples of single-chain proteins that have multiple cofactors
(or even multiple chain proteins that have multiple cofactors
bound to a single chain)?
I’m not bothered (at the moment) about proteins that have
cofactors bound to different chains.
I thought this would be a good place to ask…
Harry
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