Hi Harry, Maybe you could have a look at acetohydroxyacid synthase (AHAS). The catalytic subunit (dimer) contains FAD, ThDP and Mg2+ bound to the dimer interface. If you consider the holoenzyme complex (which consists of multiple catalytic and regulatory subunits) AHAS is bound to ATP too. There are several structures for both, the catalytic subunit and the holoenzyme complex, in the PDB.
I hope that helps. Best regards, Mario El vie, 20 de dic. de 2024 5:37 a. m., Harry Powell < 0000193323b1e616-dmarc-requ...@jiscmail.ac.uk> escribió: > Hi folks > > I’m familiar with enzymes that have a single co-factor (for example haem > in myoglobin [or in the individual chains in haemoglobins] or FAD in > flavoproteins), but was wondering if there are examples of single-chain > proteins that have multiple cofactors (or even multiple chain proteins that > have multiple cofactors bound to a single chain)? > > I’m not bothered (at the moment) about proteins that have cofactors bound > to different chains. > > I thought this would be a good place to ask… > > Harry > ######################################################################## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a > mailing list hosted by www.jiscmail.ac.uk, terms & conditions are > available at https://www.jiscmail.ac.uk/policyandsecurity/ > ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
