[NMusers] Uppsala Pharmacometric Summer School (UPSS) 2025

upss Best wishes, Zhe, Youjung and Mats, on behalf of the Uppsala Pharmacometrics, PKPD and Clinical Pharmacy Research Groups. Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmacy Uppsala University Box 580 75123 Uppsala Sweden Phone: +46 18 4714105 www.farmaci.uu.se<http://www.f

[NMusers] Uppsala Pharmacometric Summer School (UPSS) 2024 -reminder of approaching deadline

ics and PKPD Research Groups. Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmacy Uppsala University Box 580 75123 Uppsala Sweden Phone: +46 18 4714105 www.farmaci.uu.se<http://www.farmaci.uu.se/research/researchgroups/pharmacometrics/> När du har kontakt med oss på U

[NMusers] FW: Uppsala Pharmacometric Summer School (UPSS) 2024 -reminder of approaching deadline

ics and PKPD Research Groups. Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmacy Uppsala University Box 580 75123 Uppsala Sweden Phone: +46 18 4714105 www.farmaci.uu.se<http://www.farmaci.uu.se/research/researchgroups/pharmacometrics/> När du har kontakt med oss på U

[NMusers] Uppsala Pharmacometric Summer School (UPSS) 2024

ics and PKPD Research Groups. Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmacy Uppsala University Box 580 75123 Uppsala Sweden Phone: +46 18 4714105 www.farmaci.uu.se<http://www.farmaci.uu.se/research/researchgroups/pharmacometrics/> När du har kontakt med oss på U

[NMusers] Uppsala Pharmacometric Summer School - UPSS

ics and PKPD Research Groups. Mats Karlsson, PhD Professor of Pharmacometrics Head of Department Dept of Pharmacy Uppsala University Box 580 75123 Uppsala Sweden Phone: +46 18 4714105 www.farmaci.uu.se<http://www.farmaci.uu.se/research/researchgroups/pharmacometrics/> N?r du har kontakt

[NMusers] Uppsala Pharmacometric Summer School - UPSS

ics and PKPD Research Groups. Mats Karlsson, PhD Professor of Pharmacometrics Head of Department Dept of Pharmacy Uppsala University Box 580 75123 Uppsala Sweden Phone: +46 18 4714105 www.farmaci.uu.se<http://www.farmaci.uu.se/research/researchgroups/pharmacometrics/> När du har kontakt

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[NMusers] Two online NONMEM courses for East Asia, Japan and Oceania, June 22-23 & June 25-26

. Course 1: Advanced methods for population model building, evaluation, and usage in NONMEM June 22-24, 2020 Prof. Andrew Hooker & Prof. Mats Karlsson Pharmacometric modeling has become a pillar in model in

[NMusers] 2 Advanced NONMEM courses given in both US and Europe in 2020

ored functionality allow command-line transformations of models. Mats Karlsson and Andrew Hooker will give a 2.5-day course on “Advanced methods for population model building, evaluation and usage in NONMEM”. The course presents strategies for model building and improvement, the latest methods

[NMusers] UPSS - Uppsala Pharmacometric Summer School 2020

mail with information about registration will be sent in January. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.uu.se/research/rese

[NMusers] 2 Advanced NONMEM courses given in both US and Europe in 2020

ored functionality allow command-line transformations of models. Mats Karlsson and Andrew Hooker will give a 2.5-day course on “Advanced methods for population model building, evaluation and usage in NONMEM”. The course presents strategies for model building and improvement, the latest methods for m

RE: [NMusers] inclusion of covariates with $PRIOR

Hi Anna, That you want to explore covariate relationships on a parameter suggests that you believe your data contain plenty of information about the parameter. Therefore do you really need to use a prior on the parameter(s) in question? A little more info around what your “base” model is and wh

RE: [NMusers] VPCs confidence intervals?

Hi Elena and Bill, I think this has been discussed before in this forum. The VPCs central metric are the prediction of data percentiles. If you focus on the difference between e.g. the 5th and 95th percentile based on the simulated data you will have a prediction interval, like Bill states. If

RE: [NMusers] Ordinal data model: Incorporation of variability & assessment of predictive performance

Hi Eduard, If you want to have a minimalistic model, with respect to both fixed effects and random effects, but still incorporate all 4 categories as well as the Markov element, you can try the minimal Continuous-Time Markov Model (mCTMM) described in "A Minimal Continuous-Time Markov Pharmacom

RE: [NMusers] Time After Dose example in help/html

After Dose example in help/html The following email supercedes the email of November 27, 2018. At the suggestion of Mats Karlsson, it also computes TADA, which is TAD relative to the time when the dose was administered, ignoring ALAG. The original variable TAD is now called TADE, which is TAD

RE: [NMusers] Time After Dose example in help/html

Dear Alison, I have always considered the time-after-dose variable to provide values related to when the dose was administered, not that time plus any ALAG. If I read your code right, you propose to do it as administration time + ALAG. I would argue that it is more valuable to have the former.

RE: [NMusers] $PRIOR with normal for OMEGA?

that automatically in PsN). As Andy writes there are pros and cons with different priors. While IW has a better shape to its prior for variances, it is problematic that there is no correlation between the typical value estimates and their variances. Best regards, Mats Mats Karlsson, PhD

[NMusers] DDMoRe Model Repository reaching 100 models

sparency are essential to allow others to critique and follow our work. Don't you agree? Help us build the future, improve YOUR products and be a contributor! Come and ask us all your questions at the DDMoRe presentation at ACoP on Monday 24th October from 6.00 to 7.30 PM! DDMoRe foundatio

RE: [NMusers] Additive plus proportional error model for log-transform data

to solve this problem for the indicated formulas? 2. Are the two formulas below equally valid? 3. Is there an alternative formula that I can use which does not have this numerical problem? 4. Any reference paper that discusses this subject? Here are the two formulas: 1. For

RE: [NMusers] Splitting the residual error

simple way of doing it, like allowing a separate residual error magnitude up until a little after Tmax. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46

RE: [NMusers] Splitting the residual error

c models: illustrated with an analysis of moxonidine data from congestive heart failure patients.<http://www.ncbi.nlm.nih.gov/pubmed/9795882> Karlsson MO, Jonsson EN, Wiltse CG, Wade JR. J Pharmacokinet Biopharm. 1998 Apr;26(2):207-46. PMID: 9795882 Mats Karlsson, PhD Profe

Re: [NMusers] Parameter Uncertainty and Covariate effects

Dear Sven If you don't assume the covariance between THETA(1) and THETA(2) to be zero but use the estimated covariance value, you do let the data speak. A problem in this respect is that publications never give such values even if it of course is possible. With online access to model code and o

RE: [NMusers] Problem of STS in NONMEM

Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.uu.se/research/researchgroups/pharmacometrics/<http://www.farmbio.uu.se/research/researchgro

[NMusers] DDMoRe launches a new platform

Please find a press release at the site below describing the features of a new platform aiming to advance quantitative drug development. http://www.ddmore.eu/sites/ddmore/files/DDMoRe%20press%20release%20Dec%202015.pdf on behalf of colleagues from the DDMoRe project

RE: [NMusers] Error in LSODA: Code -5

testing in population pharmacokinetic models: illustrated with an analysis of moxonidine data from congestive heart failure patients. Karlsson MO, Jonsson EN, Wiltse CG, Wade JR. J Pharmacokinet Biopharm. 1998 Apr;26(2):207-46. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics

[NMusers] RE: Is it reasonable to add covarite to PD parameters kin or kout?

ation both as a covariate and dependent variable. Approaches to handling pharmacodynamic baseline responses. Dansirikul C, Silber HE, Karlsson MO. J Pharmacokinet Pharmacodyn. 2008 Jun;35(3):269-83. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosci

RE: [NMusers] Simulo: a new service for drug trial simulation

d software though. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics   Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala   Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.uu.se/research/researchgroups/pharmacometrics/ -Origin

RE: [NMusers] Fwd: Should we generate VPCs with or without uncertainty?

with every population parameter vector used in the clinical trial simulation and look for outrageously poor description of the original data, but that is a bit too much for most, including me. Better to rely on good methods for parameter uncertainty). Best regards, Mats Mats Karlsson, PhD

RE: [NMusers] RE: Dataset coding for baseline endogenous substance

patterns become too intricate. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.uu.se/research/researchgroups/pharmacometrics/<h

RE: [NMusers] variation of time values in output data

Dear Diane-Charlotte, NONMEM interprets DATE in your in-data and makes use of it. If you don’t want that, rename DATE to something that is not recognized. Each date aboce the first adds 24 h to your time column Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of

[NMusers] Stockholm Uppsala Pharmacometrics meeting April 15th

nt model for the immunogenicity of certolizumab pegol in rheumatoid arthritis subjects Mats Karlsson, Uppsala University Welcome, Sofia Friberg Hietala Fredrik Jonsson Mats Karlsson Marie Sandström Janet Wade Johan Wallin Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical

RE: [NMusers] Genotype data missing in some individuals

lsson MO. AAPS J. 2013 Oct;15(4):1035-42. doi: 10.1208/s12248-013-9508-0. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics   Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala   Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.

SV: [NMusers] OMEGA matrix

nonparametric option does allow a fuller description of the correlation than the linear one though, so if that was the problem, $NONP may offer a solution. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box

Re: Want to create custom iso

replace the LibreOffice RPM on the DVD and then rebuild the comps.xml Example: http://markliggett.wordpress.com/2009/11/30/custom-installation-centosrhel-dvd/ And for your kickstart %post work, what does /mnt/sysimage/root/my-post-log say ? /Mats -- Mats Karlsson

RE: [NMusers] Prediction with parameter estimates on new data

population and individual). Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.uu.se/research/researchgroups/pharmacometrics/<h

Re: Hjälp

On 2013-09-20 07:41, andrea nordqvist wrote: Hejsan jag är en tjej som är 14 år och jag har ubuntu på min dator, jag behöver lite hjälp så jag visste inte vart jag skulle skicka till. Men iaf jag vill spela the sims 3 på min dator men det står att det inte går att öppna skivan, måste man ha et

RE: [NMusers] Parameter Estimation in IF Conditioning Statement

mechanism-based approach for absorption modeling: the Gastro-Intestinal Transit Time (GITT) model. STEP = EXP(X*GAM)/(EXP(X*GAM)+EXP(X50*GAM)) Where X50 (inflection point) would be estimated and GAM (steepness) typically fixed. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics

RE: [NMusers] Time-varing covariate

, you may not need to have to use EVID=2 to make the covariate change at other times than event times (as my example code tried to illustrate). Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box

RE: [NMusers] Time-varing covariate

Pharmacol. 2004 Oct;58(4):367-77. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 <http://www.farmbio.uu.se/resea

Re: [NMusers] Time-varing covariate

gt; Leonid > Original email: > ----- > From: Mats Karlsson mats.karls...@farmbio.uu.se > Date: Sat, 24 Aug 2013 10:02:00 +0200 > To: william.s.den...@pfizer.com, ellen.siwei...@gmail.com, > nmusers@globomaxnm.com > Subject: RE: [NMusers] Time-varing covariate > > > Dear

RE: [NMusers] Time-varing covariate

inear interpolation between observed covariate values $ERROR OCOV =COV;store previous time OTIM =TIME ;store previous time (NB haven't tested the code). Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty o

[NMusers] Covariate model building course before PAGE

Registration for a course on Covariate model building and evaluation in Glasgow June 10-11 has just opened at www.uppsala-pharmacometrics.com Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University

RE: [NMusers] Mixture model simulation

*(CL1 + CLr)* EXP(ETA(1)) CL=(1.0-Z)*(CL2 + CLr)* EXP(ETA(2)) V2 = THETA(4)*(WT/70)*EXP(ETA(3)) (I'm not sure about your ETA variance structure as it is not entirely provided, but if you use a covariance between CL and V use also separate ETAs for V between mixtures) Best regards, Mats Mats Kar

RE: [NMusers] M3 method and multiple LOQ values

$ERROR IPRED=F LOQ=LLOQ DUM=(LOQ-IPRED)/(SQRT(SIGMA(1,1))*IPRED) CUMD=PHI(DUM) IF (BQL.EQ.0) THEN F_FLAG=0 Y=IPRED*(1+ ERR(1)) ENDIF IF (BQL.EQ.1) THEN F_FLAG=1 Y=CUMD ENDIF $EST METHOD=COND INTER LAPLACIAN $SIGMA .1 Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics

RE: [NMusers] Bootstrap, re-using inital model run results

Hi Anuba, I would agree with your suggestion. That is how I usually do it. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18

RE: [NMusers] Bootstrap, re-using inital model run results

, you could use the "-out=xxx.yyy" to point to the correct file if that does not follow naming conventions. If you have not run it and really don't want to run it, you could substitute xxx.yyy for some other output file with similar structure. Best regards, Mats Mats Karlsso

RE: [NMusers] FW: Intersubject Variability in Logistic Regression

M you can just specify > $ESTIMATION MET=0 LIKE MAX=500 You should omit or rename the "ID" column, as NONMEM would expect ETAs when ID as in the data set. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of

RE: [NMusers] M3 method with log transformed data

Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of

RE: [NMusers] RE: Proper way to handle the pre-first dose PK observation for non-endogenous drug

more relevant. If it is not, Nick's is more appropriate. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 -Original Message- F

RE: [NMusers] VPC question

ieve that the psn user guide for npc/vpc (npc_vpc_userguide.pdf) contains the information you seek. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714

RE: [NMusers] time-to-event simulation based diagnostic

Dear Francois, Unless you create a new data set where events are allowed to occur at any possible time (usually a dense time grid), then the result that you have got is rather the expected (i.e. too good to be true). Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics

RE: [NMusers] single-patient AUC

population PK model as prior, NONMEM and other non-linear mixed effects models are probably preferable. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics FIRST WORLD CONFERENCE ON PHARMACOMETRICS, 5-7 September 2012, Seoul ( <http://www.go-wcop.org/> www.go-wc

[NMusers] Covariate modeling course in Philadelphia Oct 22-23, 2012

558-69. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/ Phone: +46 18 4714105 Fax +

[NMusers] Covariate modeling course in Philadelphia Oct 22-23, 2012

bayes estimates for diagnostics: problems and solutions. AAPS J. 2009 ;11:558-69. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala http://www.farmbio

RE: [NMusers] Question about mixture model of Ka

to keep this parameterization for P(1), maybe you should try switching initial est's between THETA3 and THETA4. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics FIRST WORLD CONFERENCE ON PHARMACOMETRICS, 5-7 September 2012, Seoul ( <http://www.go-wcop.org/&

RE: [NMusers] Question about interoccation variability

Dear Claire, If you have data only from oral doses and covariances between disposition parameters (CL; V), then you will not get any further improvement by introducing variability in F1. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics FIRST WORLD CONFERENCE ON

RE: [NMusers] Priors and covariate model building

lable. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics FIRST WORLD CONFERENCE ON PHARMACOMETRICS, 5-7 September 2012, Seoul (www.go-wcop.org) Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 47

RE: [NMusers] Question about handling BLOQ data with mixture model

Hi Martin, If you write P(3) =1-P(1)-P(2) you reduce the risk of writing something incorrect J Mats Karlsson Mats Karlsson, PhD Professor of Pharmacometrics FIRST WORLD CONFERENCE ON PHARMACOMETRICS, 5-7 September 2012, Seoul ( <http://www.go-wcop.org/> www.go-wcop.org) D

[mojo-dev] [jira] (MOJO-1821) maven-wagon-plugin requires apache commons-io

Alexander Goehrings solution works! Change By: Mats Karlsson (21/May/12 8:35 AM

[mojo-dev] [jira] (MOJO-1821) maven-wagon-plugin requires apache commons-io

Mats Karlsson created MOJO-1821: --- Summary: maven-wagon-plugin requires apache commons-io Key: MOJO-1821 URL: https://jira.codehaus.org/browse/MOJO-1821 Project: Mojo Issue Type: Bug

RE: [NMusers] time-dependent clearance model

simple starting model, you can try combining the two. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 From: owner

RE: [NMusers] Coding delayed covariate effects

ETA10 ONEHEADER NOPRINT FILE=patab31 Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 -Original Message- From: owner

FW: [NMusers] OMEGA priors using modes of inverse Wishart matrix

SE = Standard error of Omega^2 (from output f previous) Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 From: Bauer,

RE: [NMusers] OMEGA priors using modes of inverse Wishart matrix

User's Guides, you may find useful info in Gisleskog et al J Pharmacokinet Pharmacodyn. 2002 Dec;29(5-6):473-505. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Up

RE: [NMusers] Output EPS(1) after an $EST step?

) and the agreement between epsilon and the residual is lost. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 From

[NMusers] Eight Postdoctoral research positions in Pharmacometrics at Uppsala Univeristy

, 2012. Please specify a time window for possible starting dates. For further information and applications please contact Mats Karlsson mats.karls...@farmbio.uu.se. Some general information about the research group can be found at http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/ and

RE: [NMusers] Confidence intervals of PsN bootstrap output

this upper boundary. If, as you say, the analyst has carefully thought through the boundaries, an estimate at the boundary should represent the global minimum within the reasonable parameter range. I think one can make a strong argument for not discarding such runs. Best regards, Mats Mats Karlsson, PhD

[NMusers] PhD student positions in pharmacometrics open for application

The pharmacometrics research group at Uppsala University are enrolling new PhD students. Information at http://www.personalavd.uu.se/ledigaplatser/engindex.html Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University

Re: [CentOS-docs] New web site vote

An idea, with all 16x9 display formats, would a different design that take that into consideration ? Use more with than height ? Just a 20cent idea Kind regards Mats On Sat, Apr 16, 2011 at 19:55, wrote: > Gentlemen, > > My choice is wireframe 1. Regarding the search function, there are t

RE: [NMusers] basic questions...

assuring that the residual error model is appropriate. Better alternatives are always welcome. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Sweden Postal address: Box 591, 751 24 Uppsala, Sweden Phone +46

RE: [NMusers] Autoinduction model - An increased clearance(day 1- 14)

nt on the concentration of drug rather than an on/off ). The number of parameters is no more than the one you're using now, but avoids the change-point which often cause numerical problems. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical B

Re: How to detect the number of network adapters installed from kickstart file for network config?

On Wed, Feb 23, 2011 at 03:03, Pat wrote: > On Feb 19, 2011, at 6:57 PM, peter Sjoberg wrote: >> Well, dunno about works but a simpler version at least >> Task: if eth1 exist - configure it >> Solution: >> >> #Top part: >> #Always config eth0 >> network --device eth0 --bootproto dhcp >> %include /

Re: How to detect the number of network adapters installed from kickstart file for network config?

On Sat, Feb 19, 2011 at 04:09, Patrick Lists wrote: > You could test for the number of interfaces. Since I'm a total n00b in this > area hopefully the experienced folks who monitor this list will have a good > laugh at my "scripting" and come up with something better that actually > works :) > > H

Re: [CentOS-docs] Emulate a fixed IP address using MAC address with DHCP

OK, Im happy to help. Can you change so I have permits to do the appropriate changes? My account is MatsOKarlsson Kind regards Mats ___ CentOS-docs mailing list CentOS-docs@centos.org http://lists.centos.org/mailman/listinfo/centos-docs

Re: [CentOS-docs] Emulate a fixed IP address using MAC address with DHCP

Nice "Tips"! A comment about dhcp server info. To get the dhcp lease info from a dhclient, that info is stored in dhclient.leases. The router/dhcp server info described in section "Home router with DHCP and DNS" could be made more generic by changing the heading and the context. Heading example

RE: [NMusers] Rational of using IOV

Seems like the mail below from last week never appeared on the nmusers. Probably the discussion became too long (or too hair-splitting.). Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Sweden Postal address

RE: [NMusers] Rational of using IOV

IOV may not be modeled ideally. Then however, not only IOV, but also IIV and RV become “nuisance” parameters as they will not represent the true IIV or RV. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Sweden

Re: vmware

Varför ska den göra det ? Lite av virtualiserings iden är att separera vm från hårdvaran så att vm'en kan köras/flyttas oberoende av hårdvaran. /Mats Mob : +46 76 055 88 67 @: mats.o.karls...@gmail.com 2010/10/9 mattias : > Om man har en dator som stödjer hårdvaruvirtualisering ska inte en v

RE: [NMusers] Baseline as a covariate

more complex than easily handled via a covariance, then I suggest that you use the baseline observation as a covariate with error (Dansirikul et al Pharmacokinet Pharmacodyn. 2008 Jun;35(3):269-83.) Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical

RE: [NMusers] ALAG with transit model

Dear Ann, Change to ALAG4. Note that you could use ADVAN 5 or 7 for this model if you specify all rate constants. These should be faster. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Sweden Postal

Re: [Sip-implementors] Looking for blogs on SIP

Look at the original question "Could anyone suggest any SIP blogs or websites, where I can learn more on SIP." /Mats On Fri, Jul 23, 2010 at 15:17, Iñaki Baz Castillo wrote: > 2010/7/23 Mats Karlsson : > > http://voip-info.org > > I don't think that is a blog ;)

Re: [Sip-implementors] Looking for blogs on SIP

http://voip-info.org Kind regards Mats On Fri, Jul 23, 2010 at 10:59, Iñaki Baz Castillo wrote: > 2010/7/23 Seshagiri Kondaveti : > > Could anyone suggest any SIP blogs or websites, where I can learn more on > SIP. > > http://blog.tekelec.com/ > > > -- > Iñaki Baz Castillo > > > _

Re: SV: asterisk

Du har ett bra forum, voip-forum.se, prova där... 2010/7/19 mattias > Jadå men finns ingen svensk lista för asterisk > > -Ursprungligt meddelande- > Från: ubuntu-se-boun...@lists.ubuntu.com > [mailto:ubuntu-se-boun...@lists.ubuntu.com] För Joakim Kennedy > Skickat: den 19 juli 2010 17:52

Re: apt-get kan ej packa upp indexfiler

Prova med att byta till andra servrar, dvs ersätt se med no eller uk. /Mats 2010/7/9 Conny Enström > Ubuntu 10.04 > När jag kör apt-get update så får jag detta fel: > > > -snip- > Bra http://packages.medibuntu.org lucid/free Packages >

Re: multiple OS on kickstart server

Or perhaps http://www.fastdeploy.com/ is something for you ? Kind regards Mats On Wed, Jul 7, 2010 at 11:23, Jan Wildeboer wrote: > On 07/06/2010 10:19 PM, Shabazian, Chip wrote: >> >> You simply need to copy the initrd.img and vmlinuz from the Fedora 12 >> install media to your tftp server, and

Re: Re: Iptables på servern, men hur öppnar jag po rtar för utgående?

Pontus, Prova exemplet här: http://www.brandonhutchinson.com/iptables_fw.html Du behöver ändra raden: iptables -A INPUT -p tcp -s 192.168.1.100 --dport 22 -m state --state NEW -j ACCEPT till att se ut så här istället: iptables -A INPUT -p tcp -s 0/0 -d 10.0.0.10 --dport 22 -m state --state NEW -

Re: Ubuntu Utbildning

http://www.comptia.org/certifications/listed/linux.aspx Är själv certad efter den ;-) 2010/6/14 Jari Saarelainen : > gnutiken.se > > Den 13 juni 2010 23.12 skrev Gilad Nevo : >> >> Hej >> Är det någon som känner till en bra utbildningsanordnare av >> Linux/Ubuntu/Mysql/Apache osv...(distans eller

Re: Ubuntu Utbildning

www.studera.nu /Mats 2010/6/13 Gilad Nevo : > Hej > Är det någon som känner till en bra utbildningsanordnare av > Linux/Ubuntu/Mysql/Apache osv...(distans eller på plats, kanske > kombinera)? > > Ha dé > /GN -- ubuntu-se mailing list ubuntu-se@lists.ubuntu.com https://lists.ubuntu.com/mailman/

Re: Krachat filsystem.

Evert, Spana in tråden : http://ubuntuforums.org/showthread.php?t=1245536&highlight=bad+superblock Kind regards, Med vänliga hälsningar, Ja mata (じゃまた。) Mats 2010/6/8 Jari Saarelainen > det finns en liten chans att det går att hämta hem filerna via en live-cd > och usb-sticka... > jag vill minna

Re: Företagsprogram

Web baserade lösningar har en annan utmaning, man måste jämt vara uppkopplad och det är jag inte. Men annars är det ett alternativ för de med mer statiska arbetsplatser. /Mats -- ubuntu-se mailing list ubuntu-se@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-se

Re: Företagsprogram

Systemkrav Operativsystem: Microsoft Windows 9x, 2000, XP, Vista eller 7 Oj tänkte inte på att jag behövde specifiera att det var för Ubuntu EJ windows! /Mats 2010/6/3 Gilad Nevo > Kolla Denna länk: > http://www.enskildfirma.nu/index.html > > Den 3 juni 2010 13.57 skrev M

Företagsprogram

Någon som vet nått bra affärssystem för nystartade företag på 1-3 personer ? Affärssystemets minimumkrav är bokföring med fakturering via brev/pdf och ingen e-faktura (fast det vore guld om det finns). Med vänliga hälsningar Mats -- ubuntu-se mailing list ubuntu-se@lists.ubuntu.com https://list

FW: [NMusers] distribution assumption of Eta in NONMEM

It seems my mails are not appearing on nmusers – maybe a sign that the thread has gone on too long. Anyway the one below is from yesterday. /Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Box 591 751 24 Uppsala Sweden phone: +46

RE: [NMusers] distribution assumption of Eta in NONMEM

0.08444 1.74E-24 0.001808 LGPAR1 = THETA(2) LGPAR2 = THETA(3) PHI = LOG(LGPAR1/(1-LGPAR1)) PAR1 = EXP(PHI+ETA(1)) ETATR = (PAR1/(1+PAR1)-LGPAR1)*LGPAR2 HILL=THETA(1)*EXP(ETATR) Y=1.1**HILL/(1.1**HILL+1) + EPS(1) Best regards, Mats Mats Karlsson, PhD

RE: [NMusers] distribution assumption of Eta in NONMEM

transformation TVCL=THETA(1) HTPAR=THETA(2) ETATR=ETA(1)*SQRT(ETA(1)*ETA(1))**HTPAR CL=TVCL*EXP(ETATR) Logit transformation TVCL=THETA(1) LGPAR1 = THETA(2) LGPAR2 = THETA(3) PHI = LOG(LGPAR1/(1-LGPAR1)) PAR1 = EXP(PHI+ETA(1)) ETATR = (PAR1/(1+PAR1)-LGPAR1)*LGPAR2 CL=TVCL*EXP(ETATR) Mats Mats Karlsson, PhD

RE: [NMusers] distribution assumption of Eta in NONMEM

Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Box 591 751 24 Uppsala Sweden phone: +46 18 4714105 fax: +46 18 471 4003 From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Nick Holford Sent: Monday

RE: [NMusers] distribution assumption of Eta in NONMEM

results Stuart were basing his thoughts on, do you? Maybe the keyword in Stuart’s sentence is “largely”. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Box 591 751 24 Uppsala Sweden phone: +46 18 4714105 fax

RE: [NMusers] distribution assumption of Eta in NONMEM

non-parametric methods where very little distributional assumption is being made. Semi-parametric methods are essentially parametric but parameters are estimated that relates not just the magnitude, but also the shape of the distribution.) Best regards, Mats Mats Karlsson, PhD Professo

RE: [NMusers] distribution assumption of Eta in NONMEM

dissimilar to a cumulative normal are things to look out for. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Box 591 751 24 Uppsala Sweden phone: +46 18 4714105 fax: +46 18 471 4003 From: owner-nmus

Re: ett förslag

2010/5/12 Andreas Olsson > ons 2010-05-12 klockan 19:27 +0200 skrev Lars Johnson: > > om man kunde inkludera ett program typ Teamviewer redan på livecd skulle > > nya användare lättare kunna få hjälp med installation och program och > > sådant i början av vänner eller från forum med frivilliga >

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