Dear Diane-Charlotte, NONMEM interprets DATE in your in-data and makes use of it. If you don’t want that, rename DATE to something that is not recognized. Each date aboce the first adds 24 h to your time column
Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.uu.se/research/researchgroups/pharmacometrics/<http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/> From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Diane-Charlotte Imbs Sent: Tuesday, April 21, 2015 11:47 AM To: Leonid Gibiansky Cc: nmusers@globomaxnm.com Subject: Re: [NMusers] variation of time values in output data Thank you, Leonid, for your answer but you can see (below) it’s not a rounding issue ; there are udge variations of time ?!!! INPUT FILE : ID DATE TIME DV AMT RATE MDV EVID 3 1 0 0 2000 -2 1 1 3 1 2.6 1060 . . 0 0 3 1 170.1166667 331 . . 0 0 3 2 170.1166667 . 2000 -2 1 1 3 2 172.1166667 1220 . . 0 0 3 2 326.3333333 220 . . 0 0 3 3 326.55 . 2000 -2 1 1 3 3 328.6166667 964 . . 0 0 3 3 504.8333333 1260 . . 0 0 OUTPUT FILE : ID DATE TIME IPRED CL D1 V1 IWRES 3 1 0 0 1.7711 113.17 35.217 0 3 1 2.6 1223 1.7711 113.17 35.217 -0.13328 3 1 170.12 567.29 1.7711 113.17 35.217 -0.41653 3 2 194.12 169.68 1.7711 112.49 35.217 -1 3 2 196.12 1114 1.7711 112.49 35.217 0.09514 3 2 350.33 1110 1.7711 112.49 35.217 -0.80181 3 3 374.55 328.36 1.7711 140.63 35.217 -1 3 3 376.62 1089.8 1.7711 140.63 35.217 -0.11542 3 3 552.83 1208.1 1.7711 140.63 35.217 0.04297 Loïc FIEVET Interne IPR en pharmacocinétique Institut Universitaire du Cancer Toulouse - Oncopole 1 avenue Irène Joliot-Curie 31059 TOULOUSE Cedex 9 2015-04-20 19:21 GMT+02:00 Leonid Gibiansky <lgibian...@quantpharm.com<mailto:lgibian...@quantpharm.com>>: it could be rounding issue when the precision of the TIME in the data file exceeds the precision of the TIME in the output of the table. You could increase precision of the output using format statement (see manual). Other than that, NONMEM should not change TIME variable. Leonid -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com<http://www.quantpharm.com> e-mail: LGibiansky at quantpharm.com<http://quantpharm.com> tel: (301) 767 5566 On 4/20/2015 12:12 PM, Diane-Charlotte Imbs wrote: Dear nonmem users, We used the option “-2 RATE” of NONMEM (actual rate of infusion is unknown): within the control stream: D1=THETA(1) Moreover, since several infusions are given to the same patients, we have added an inter-occasion variability on D1 (see code below)* We obtained nice fit BUT in the OUTPUT DATA: TIME values corresponding to blood samples (and DV) are not identical to the actual TIME values of the INPUT data !? It seems that NONMEM program adjusts rate values, their interoccasion variability, and sampling times to have a good fit *How to fix TIME value corresponding to blood samples ? Indeed, we do not know the actual infusion rate but we do know the sampling times.* ** Can anyone tell me if I chose the right model or help me resolving this? Thanks in advance, *$PK OCC1=0 OCC2=0 IF(DATE.EQ.1) OCC1=1 IF(DATE.EQ.2) OCC2=1 D1=THETA(1)*EXP(ETA(3)+ETA(4)*OCC1+ETA(5)*OCC2) $THETA (0,168,);D1 $OMEGA .1 ; iiv d1 $OMEGA BLOCK(1) .01 ; iov ETA4 OCC1 $OMEGA BLOCK(1) SAME ; iov ETA5 OCC2 *Loïc FIEVET* */Interne IPR en pharmacocinétique (1^er semestre)/* *Institut Universitaire du Cancer Toulouse - Oncopole* 1 avenue Irène Joliot-Curie 31059 TOULOUSE Cedex 9
