Hi, In many cases you don't even need to use $ABB COMRES to do response-adaptive designs, simulated response could just impact a bioavailability term (Fx) of the next dose(s) to indicate dose change. I'm sure that more complex response-adaptive designs could benefit from a dedicated software though.
Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 www.farmbio.uu.se/research/researchgroups/pharmacometrics/ -----Original Message----- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Leonid Gibiansky Sent: Tuesday, June 23, 2015 4:14 PM To: Faelens, Ruben (Belgium); nmusers@globomaxnm.com Subject: Re: [NMusers] Simulo: a new service for drug trial simulation Actually, nonmem can be used to simulate the response-based dose adaptation without iteratively rerunning your model, with single simulation (using $ABB COMRES functionality to pass simulated response to the dose-adjustment algorithm code), although it is indeed cumbersome Leonid -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com e-mail: LGibiansky at quantpharm.com tel: (301) 767 5566 On 6/23/2015 4:48 AM, Faelens, Ruben (Belgium) wrote: > Dear NONMEM users, > > We all know how difficult it is to simulate full drug trials using > NONMEM. It is often necessary to generate the full dosing scheme(s) > beforehand, and response-based dose adaptation requires iteratively > rerunning your model until you have the results you are happy with. > > At SGS Exprimo, we have been working for 4 years to develop a new > software that makes drug trial simulation much more straight-forward. > The software has been developed in collaboration with Roche and has > been used internally within SGS Exprimo for the last 2 years. We are > now presenting it to the public as a new consultancy service. You may > have seen us in Crete at PAGE 2015. > > We invite you to visit our website www.simulo.eu > <http://www.simulo.eu> or contact us directly to request an on-site > demo or web conference, or to ask any questions you may have. > > We look forward to hearing from you. > > Kind regards, > > Ruben Faelens for SGS Exprimo > > *Ruben Faelens, MSc* > *Life Science Services - Exprimo* > IT Scientist > > Phone: > > > > +32 494 06 72 59 > > > > > > > > > > > > > > > > > > > > E-mail: > > > > _ruben.fael...@sgs.com <mailto:ruben.fael...@sgs.com>_ > > > > > > > > > > > > > > > > > > > > Web: > > > > www.exprimo.com <http://www.exprimo.com/> > > > > > > > > > > > > > > > > > > > > Information in this email and any attachments is confidential and > intended solely for the use of the individual(s) to whom it is > addressed or otherwise directed. Please note that any views or > opinions presented in this email are solely those of the author and do > not necessarily represent those of the Company. Finally, the recipient > should check this email and any attachments for the presence of > viruses. The Company accepts no liability for any damage caused by any > virus transmitted by this email. All SGS services are rendered in > accordance with the applicable SGS conditions of service available on > request and accessible at > http://www.sgs.com/en/Terms-and-Conditions.aspx
