Thank you!

Sent from my iPhone

On May 8, 2013, at 8:17 AM, Douglas N Greve <gr...@nmr.mgh.harvard.edu> wrote:

> 
> Hi Alejandra, I don't work with children, so I'll let someone else (Lilla? 
> Rudolph?) answer.
> doug
> ps. Please remember to copy the list on responses. Thanks!
> 
> On 05/08/2013 01:19 AM, Alejandra Infante wrote:
>> Thank you! I might have asked this at the training, but I am still not clear 
>> on whether the estimated ICV (from freesurfer) is reliable if your 
>> population of interest are children? Or would you recommend manual edits 
>> (when needed) after checking the quality of the talairach registration file 
>> using tkregister2 --s subjid --fstal --surfs?
>> 
>> 
>> On Tue, May 7, 2013 at 7:52 PM, Douglas Greve <gr...@nmr.mgh.harvard.edu 
>> <mailto:gr...@nmr.mgh.harvard.edu>> wrote:
>> 
>> 
>>    It is neither:) See http://surfer.nmr.mgh.harvard.edu/fswiki/eTIV
>>    and/or Buckner et al. (2004) NeuroImage
>>    <https://surfer.nmr.mgh.harvard.edu/fswiki/NeuroImage> 23:724-738.
>> 
>>    "Basically, total intracranial volume is found to correlate with
>>    the determinant of the transform matrix used to align an image
>>    with an atlas. The work demonstrates that a one-parameter scaling
>>    factor provides a reasonable TIV estimation. This method uses an
>>    atlas based spatial normalization procedure, and requires that the
>>    *talairach.xfm* is correct. "
>> 
>>    This performs the talairach registration for a subject. Then,
>>    based only on the numbers in the matrix, it estimates the ICV
>>    based on subjects that had similar matrices.
>> 
>>    doug
>> 
>> 
>> 
>>    On 5/7/13 9:42 PM, Alejandra Infante wrote:
>>>    Hi,
>>>    I understand that ICV is an estimated measure based on a standard
>>>    talairach transformation; however, I want to know how freesurfer
>>>    is defining intracranial volume (i.e., is this a representation
>>>    of everything within the cranium as the name implies or is it an
>>>    estimate of total brain volume, which would not include space
>>>    between skull and dura)?. We are using fs vesion 5.1
>>> 
>>> 
>>>    --     M. Alejandra Infante
>>>    Doctoral Student
>>>    SDSU/UCSD Joint Doctoral Program in Clinical Psychology
>>>    Phone: (858) 449-2950 <tel:%28858%29%20449-2950>
>>>    E-Mail: infante.alejandr...@gmail.com
>>>    <mailto:infante.alejandr...@gmail.com>
>>> 
>>> 
>>> 
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>> 
>> 
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>> 
>> 
>> -- 
>> M. Alejandra Infante
>> Doctoral Student
>> SDSU/UCSD Joint Doctoral Program in Clinical Psychology
>> Phone: (858) 449-2950
>> E-Mail: infante.alejandr...@gmail.com <mailto:infante.alejandr...@gmail.com>
> 
> -- 
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> gr...@nmr.mgh.harvard.edu
> Phone Number: 617-724-2358
> Fax: 617-726-7422
> 
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> 

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