[ccp4bb] Patenting ligand binding?

2023-07-28 Thread Winter, Graeme (DLSLtd,RAL,LSCI)
Interesting https://www.freepatentsonline.com/20230228695.pdf Patent for use of electron diffraction to assess ligand binding Stumbled across this because the patent application cites my work - felt that this would be of interest to the community … discuss? Graeme -- This e-mail and any at

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread Savvas Savvides
Dear Kevin, A similar incident from just two weeks ago, in Europe in our case, was resolved by travelling to the regional FedEx package collection/distribution center to recover the dry-shipper in person. This involved gaining access to the FedEx center and talking to the right people. I would

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Tim Gruene
Hi Graeme, do you want to discuss whether obvious steps can be patented? Cheers, Tim On Fri, 28 Jul 2023 07:45:38 + "Winter, Graeme (DLSLtd,RAL,LSCI)" <6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote: > Interesting > > https://www.freepatentsonline.com/20230228695.pdf > > Patent for

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Winter, Graeme (DLSLtd,RAL,LSCI)
Discussion topics: - does this have any hope of being enforced since - as you point out - it is a pretty obvious next step from X-rays - does anyone else who is _already doing this_ care - should we (individuals, not community) be patenting the obvious / ideas / “inventions” just in case? (w

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Randy John Read
I get the impression that these days you can patent just about anything, and instead of challenging your claims the patent examiners leave it to be settled later. A few years (probably one or two decades!) ago someone managed to patent the idea of a difference Fourier to detect binding, ignoring

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Tim Gruene
Hi Graeme, in my experience, institutions encourage patents. I suppose it is a simple way to demonstrate that Universities produce something of value (money is easy to count, value of thought is not). Personally, I think research should be as open as possible, in hardware, software, and publicatio

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Patrick Shaw Stewart
In my observation, a patent for a real invention can be very valuable On the other hand, a patent might be issued for something that isn't really an invention (as Randy says) - sure, it's a patent, but it has little value. I'm told venture capitalists like patents I sometimes apply for a patent

[ccp4bb] 4 years - Ph.D. student Fellow - Structural Glycobiology Laboratory - IBMB Barcelona, Spain

2023-07-28 Thread Marcelo Guerin
A *4 years Ph.D. position* funded by the Spanish Ministry of Science and Innovation is available at the Structural Glycobiology laboratory, Department of Structural and Molecular Biology, Institute of Molecular Biology of Barcelona (IBMB), Spanish National Research Council (CSIC), Spain. The IBMB i

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread David J. Schuller
FedEx missing deadlines on "overnight" shipments is not uncommon, I advise everyone to ship dewars to arrive at least one extra day in advance. Also, their online tracking page could be better. They show the original expected delivery time even if the shipment has already missed an intermediate

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread John R Helliwell
Dear Graeme, Yes indeed, interesting. There are clearly aspects of microED of proteins which might be documented as non-obvious otherwise it wouldn’t have been a bit stuck ie without the widespread community take up until recent years. In terms of a concept patent, which this might be interprete

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread Jon Cooper
Hello, I don't do anything MAC but maybe shipping dewars would be a good situation for an Apple Airtag, which I read about recently, or equivalent, if there are any? Best wishes, Jon Cooper. jon.b.coo...@protonmail.com Sent from Proton Mail mobile Original Message On 28 Jul 2

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Harry Powell
I’m left wondering which aspects of the patent application are novel and haven’t already been published elsewhere in the list of references (which include a number of Tamir’s other papers). Others will know - can you patent something that you have already published in a paper? I try to steer cl

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread Jurgen Bosch
The AirTag is a good idea, I shall implement that. I’ve had samples stuck from Canada to US, also in Memphis. It was just protein on dry ice but needless to say when it arrived it was very dry but no ice. Hopefully you will be lucky and retrieve your samples within the next 14 days. Jürgen __

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Ian Tickle
Hi Harry On Fri, Jul 28, 2023 at 12:54 PM Harry Powell < 193323b1e616-dmarc-requ...@jiscmail.ac.uk> wrote: > I’m left wondering which aspects of the patent application are novel and > haven’t already been published elsewhere in the list of references (which > include a number of Tamir’s other

[ccp4bb] Macs, XQuartz, ccp4i2, Coot, iMosflm....

2023-07-28 Thread Harry Powell
Hi folks I note that the installation pages for ccp4i2 tell me that I need _exactly_ version 2.8.0 of XQuartz so that things like Coot, iMosflm, etc will work. The problem with that is that my TrueType fonts seem to have disappeared from XEmacs and I’m left with the spidery bit-mapped fonts (I

[ccp4bb] Call open for beamtime at XALOC (ALBA synchrotron) in 2024, deadline 4th September

2023-07-28 Thread Roeland Boer
Dear fellow crystallographers, I would like to draw your attention to the call  for proposals for the XALOC beamline at the ALBA synchrotron, open until the 4th of September 2023. The call is for experiments to be performed during the whole year of 2024. Some features of XALOC: * Recently

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Dale Tronrud
There are certainly a large number of bad patents being issued, particularly in the US. The patent office here seems to have decided that it is easier (for them) to just approve most every application and let the courts filter out the bad ones, which requires years of work for lawyers and b

Re: [ccp4bb] Patenting ligand binding?

2023-07-28 Thread Patrick Shaw Stewart
> > "A method for soaking ligands into > macromolecule (e.g. protein) crystals (e.g. microcrystals) on EM (e.g. > TEM) grids is presented. One or more crystals on the grid are soaked > simultaneously using standard cryo-EM vitrification equipment." So, the > only claim of novelty is for soaking in

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread Lari Lehtiö
Dear all, Just a note as we have been experimenting with this lately after some lost shipments. We went with Lightbug pro and are ordering more of those. https://lightbug.io/product/pro/ One can customize it to send updates only when moving out of the premises or geofence to significantly lowe

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread Dr. Kevin M Jude
Hi all, thanks for the responses on and off list. Yesterday I got my case assigned to someone in the international shipping division, gave a physical description of my shipping case and expressed the perishable nature of the contents. My dewar turned up in Calgary last night and was just delive

[ccp4bb] Deadline approaching! Instruct-ERIC Soft X-ray Tomography workshop at Diamond Light Source...

2023-07-28 Thread Harkiolaki, Maria (DLSLtd,RAL,LSCI)
Hi everyone, We are running an Instruct-ERIC Soft X-ray Tomography workshop/school at beamline B24 at the UK synchrotron Diamond Light Source 11th - 15th of September. This is an exciting opportunity for young or experienced investigators to gain valuable hands-on experience with our pipeli

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread Jan Abendroth
Hi all, In addition to the statements above, our experience has shown that using the Customs broker as described on the CLS webpage has been helpful. Our weekly shipments from Seattle to Saskatoon typically make it overnight, worst case the next day. Also, test your dewars. They should keep cold f

Re: [ccp4bb] Dry shipper in limbo

2023-07-28 Thread Debanu Das
Hi Jan, Kevin, Our experience shipping from San Francisco to CLS has ranged from arrival on 2nd day to 10th day (both extreme), most commonly on 3rd or 4th day, irrespective of using the CLS recommended customs broker or FedEx as the international broker. The main parameter is likely if the packag