Dear Graeme,
Yes indeed, interesting.
There are clearly aspects of microED of proteins which might be documented as 
non-obvious otherwise it wouldn’t have been a bit stuck ie without the 
widespread community take up until recent years. 
In terms of a concept patent, which this might be interpreted as, an 
interesting one in my experience was the Kodak Storage Phosphor patent which 
held up Fuji for a considerable time in its commercialisation of its image 
plates even though Fuji had several specific know how patents. 
In terms of cost of patenting, especially worldwide, this is a major stumbling 
block at least at Univ Manchester who have a keen eye for whether it might be 
deemed worth it. 
Thanks for sharing.
Greetings,
John 

Emeritus Professor John R Helliwell DSc




> On 28 Jul 2023, at 08:46, Winter, Graeme (DLSLtd,RAL,LSCI) 
> <00006a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
> 
>  Interesting
> 
> https://www.freepatentsonline.com/20230228695.pdf
> 
> Patent for use of electron diffraction to assess ligand binding
> 
> Stumbled across this because the patent application cites my work - felt that 
> this would be of interest to the community
> 
> … discuss?
> 
> Graeme
> 
>  
> 
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