[ccp4bb] Patenting ligand binding?

[Winter, Graeme (DLSLtd,RAL,LSCI)]

Interesting

https://www.freepatentsonline.com/20230228695.pdf

Patent for use of electron diffraction to assess ligand binding

Stumbled across this because the patent application cites my work - felt that 
this would be of interest to the community

… discuss?

Graeme


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Re: [ccp4bb] Dry shipper in limbo

[Savvas Savvides]

Dear Kevin,

A similar incident from just two weeks ago, in Europe in our case, was resolved 
by travelling to the regional FedEx package collection/distribution center to 
recover the dry-shipper in person. This involved gaining access to the FedEx 
center and talking to the right people.

I would absolutely not wait this out because your shipment is probably 
somewhere in the corner of a distribution center used as a seat by employees 
taking a break. I can attest to the fact that they do have such corners where 
“problematic" shipments are piled up!

Despite what you were told on the phone or could deduce from any online 
tracking systems (in our case the dry-shipper was not even trackable), there is 
still a (very good) chance that your shipment might still be at a regional 
collection/distribution center.

The key is to get to any information about where this place might be, talk to 
the local people, and find out what the actual route of the shipment might have 
been after getting picked up from your lab. The routes often involve 
intermediate collection/distribution sites.

To their credit, and in contrast to the general FedEx customer service, the 
people at the regional FedEx distribution center (including the shift manager) 
were very empathic and helpful, and used means that go above and beyond SOPs to 
help. This included sharing photos of the shipment via WhatsApp with 
drivers/employees of the three previous shifts etc… Despite the volumes of work 
they handle, drivers and other courier employees actually do remember unusually 
looking shipments, such as a shipping-case containing a dry-shipper!

Best of luck and wishes,
Savvas




On 28 Jul 2023, at 08:15, Savvas Savvides  wrote:



Best wishes,
Savvas

Begin forwarded message:

From: "Dr. Kevin M Jude" mailto:kj...@stanford.edu>>
Date: 28 July 2023 at 05:16:39 CEST
To: CCP4BB@jiscmail.ac.uk
Subject: [ccp4bb] Dry shipper in limbo
Reply-To: "Dr. Kevin M Jude" mailto:kj...@stanford.edu>>


My first adventure in international crystallography is off to an inauspicious 
start. On Monday, I sent a dry shipper “overnight” from California to 
Saskatchewan, but it has been stuck in the Memphis FedEx facility for a few 
days. I’ve gotten several conflicting explanations of the status from FedEx on 
the phone, but the most likely seems that it has “pre-cleared” customs and yet 
has not yet made it to Calgary. It’s not clear whether anyone actually knows 
where the shipping case is, since I was asked to give a physical description of 
it. Is there anything else I can do from a few thousand miles away, or do I 
just have to wait this out?

--
Kevin Jude, PhD
Structural Biology Research Specialist, Garcia Lab
Howard Hughes Medical Institute
Stanford University School of Medicine
Beckman B177, 279 Campus Drive, Stanford CA 94305
Phone: (650) 723-6431



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Re: [ccp4bb] Patenting ligand binding?

[Tim Gruene]

Hi Graeme,

do you want to discuss whether obvious steps can be patented?

Cheers,
Tim


On Fri, 28 Jul 2023 07:45:38 + "Winter, Graeme (DLSLtd,RAL,LSCI)"
<6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:

> Interesting
> 
> https://www.freepatentsonline.com/20230228695.pdf
> 
> Patent for use of electron diffraction to assess ligand binding
> 
> Stumbled across this because the patent application cites my work -
> felt that this would be of interest to the community
> 
> … discuss?
> 
> Graeme
> 
> 



-- 
--
Tim Gruene
Head of the Centre for X-ray Structure Analysis
Faculty of Chemistry
University of Vienna

Phone: +43-1-4277-70202

GPG Key ID = A46BEE1A



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Description: OpenPGP digital signature

Re: [ccp4bb] Patenting ligand binding?

[Winter, Graeme (DLSLtd,RAL,LSCI)]

Discussion topics:

 - does this have any hope of being enforced since - as you point out - it is a 
pretty obvious next step from X-rays
 - does anyone else who is _already doing this_ care
 - should we (individuals, not community) be patenting the obvious / ideas / 
“inventions” just in case?

(well aware that the authors of said patent will wake up to this in a few 
hours) 

Personally, I am not comfortable with this, but maybe I am a dinosaur?

Graeme

> On 28 Jul 2023, at 09:13, Tim Gruene  wrote:
> 
> Hi Graeme,
> 
> do you want to discuss whether obvious steps can be patented?
> 
> Cheers,
> Tim
> 
> 
> On Fri, 28 Jul 2023 07:45:38 + "Winter, Graeme (DLSLtd,RAL,LSCI)"
> <6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
> 
>> Interesting
>> 
>> https://www.freepatentsonline.com/20230228695.pdf
>> 
>> Patent for use of electron diffraction to assess ligand binding
>> 
>> Stumbled across this because the patent application cites my work -
>> felt that this would be of interest to the community
>> 
>> … discuss?
>> 
>> Graeme
>> 
>> 
> 
> 
> 
> -- 
> --
> Tim Gruene
> Head of the Centre for X-ray Structure Analysis
> Faculty of Chemistry
> University of Vienna
> 
> Phone: +43-1-4277-70202
> 
> GPG Key ID = A46BEE1A
> 
> 
> 
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
> 
> This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing 
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Re: [ccp4bb] Patenting ligand binding?

[Randy John Read]

I get the impression that these days you can patent just about anything, and 
instead of challenging your claims the patent examiners leave it to be settled 
later. A few years (probably one or two decades!) ago someone managed to patent 
the idea of a difference Fourier to detect binding, ignoring the many decades 
of prior art. As far as I am aware no-one ever tried to enforce that patent.

Randy

> On 28 Jul 2023, at 09:17, Winter, Graeme (DLSLtd,RAL,LSCI) 
> <6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
>
> Discussion topics:
>
> - does this have any hope of being enforced since - as you point out - it is 
> a pretty obvious next step from X-rays
> - does anyone else who is _already doing this_ care
> - should we (individuals, not community) be patenting the obvious / ideas / 
> “inventions” just in case?
>
> (well aware that the authors of said patent will wake up to this in a few 
> hours)
>
> Personally, I am not comfortable with this, but maybe I am a dinosaur?
>
> Graeme
>
>> On 28 Jul 2023, at 09:13, Tim Gruene  wrote:
>>
>> Hi Graeme,
>>
>> do you want to discuss whether obvious steps can be patented?
>>
>> Cheers,
>> Tim
>>
>>
>> On Fri, 28 Jul 2023 07:45:38 + "Winter, Graeme (DLSLtd,RAL,LSCI)"
>> <6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
>>
>>> Interesting
>>>
>>> https://www.freepatentsonline.com/20230228695.pdf
>>>
>>> Patent for use of electron diffraction to assess ligand binding
>>>
>>> Stumbled across this because the patent application cites my work -
>>> felt that this would be of interest to the community
>>>
>>> … discuss?
>>>
>>> Graeme
>>>
>>>
>>
>>
>>
>> --
>> --
>> Tim Gruene
>> Head of the Centre for X-ray Structure Analysis
>> Faculty of Chemistry
>> University of Vienna
>>
>> Phone: +43-1-4277-70202
>>
>> GPG Key ID = A46BEE1A
>>
>> 
>>
>> To unsubscribe from the CCP4BB list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>>
>> This message was issued to members of http://www.jiscmail.ac.uk/CCP4BB, a 
>> mailing list hosted by http://www.jiscmail.ac.uk/, terms & conditions are 
>> available at https://www.jiscmail.ac.uk/policyandsecurity/
>
>
> --
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> privileged material, and are for the use of the intended addressee only. If 
> you are not the intended addressee or an authorised recipient of the 
> addressee please notify us of receipt by returning the e-mail and do not use, 
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> necessarily of Diamond Light Source Ltd.
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> damage which you may sustain as a result of software viruses which may be 
> transmitted in or with the message.
> Diamond Light Source Limited (company no. 4375679). Registered in England and 
> Wales with its registered office at Diamond House, Harwell Science and 
> Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
>
>
> 
>
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-
Randy J. Read
Department of Haematology, University of Cambridge
Cambridge Institute for Medical Research Tel: +44 1223 336500
The Keith Peters Building
Hills Road   E-mail: 
rj...@cam.ac.uk
Cambridge CB2 0XY, U.K.  
www-structmed.cimr.cam.ac.uk




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Re: [ccp4bb] Patenting ligand binding?

[Tim Gruene]

Hi Graeme,

in my experience, institutions encourage patents. I suppose it is a
simple way to demonstrate that Universities produce something of value
(money is easy to count, value of thought is not).
Personally, I think research should be as open as possible, in
hardware, software, and publications. 
The best quote is from a patent lawyer during a presentation at
Park InnoVaare (PSI  - sorry, forgot the person's name)

"Industry turns knowledge into money - Research turns money into
knowledge."

When we take a look at the value of the companies, the money we use for
research is well invested (and really just peanuts).

Cheers,
Tim


On Fri, 28 Jul 2023 08:17:35 + "Winter, Graeme (DLSLtd,RAL,LSCI)"
 wrote:

> Discussion topics:
> 
>  - does this have any hope of being enforced since - as you point out
> - it is a pretty obvious next step from X-rays
>  - does anyone else who is _already doing this_ care
>  - should we (individuals, not community) be patenting the obvious /
> ideas / “inventions” just in case?
> 
> (well aware that the authors of said patent will wake up to this in a
> few hours) 
> 
> Personally, I am not comfortable with this, but maybe I am a dinosaur?
> 
> Graeme
> 
>  [...]  
>  [...]  
>  [...]  
> 
> 



-- 
--
Tim Gruene
Head of the Centre for X-ray Structure Analysis
Faculty of Chemistry
University of Vienna

Phone: +43-1-4277-70202

GPG Key ID = A46BEE1A



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Description: OpenPGP digital signature

Re: [ccp4bb] Patenting ligand binding?

[Patrick Shaw Stewart]

In my observation, a patent for a real invention can be very valuable

On the other hand, a patent might be issued for something that isn't really
an invention (as Randy says) - sure, it's a patent, but it has little value.

I'm told venture capitalists like patents

I sometimes apply for a patent with no intention of actually getting one
just to stop anyone patenting against me - it's easy to do, and normally
competitors won't see it, whereas they might notice a peer-reviewed paper.
Patent examiners *ought *to look at papers, but in practice, they mainly
look at other patents and patent applications.

Patents don't really apply to academics in practice.

Patents shouldn't be issued for things that are obvious


https://new.epo.org/en/legal/guidelines-epc/2023/g_vii_4.html


Patrick




On Fri, Jul 28, 2023 at 9:37 AM Randy John Read  wrote:

> I get the impression that these days you can patent just about anything,
> and instead of challenging your claims the patent examiners leave it to be
> settled later. A few years (probably one or two decades!) ago someone
> managed to patent the idea of a difference Fourier to detect binding,
> ignoring the many decades of prior art. As far as I am aware no-one ever
> tried to enforce that patent.
>
> Randy
>
> > On 28 Jul 2023, at 09:17, Winter, Graeme (DLSLtd,RAL,LSCI) <
> 6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
> >
> > Discussion topics:
> >
> > - does this have any hope of being enforced since - as you point out -
> it is a pretty obvious next step from X-rays
> > - does anyone else who is _already doing this_ care
> > - should we (individuals, not community) be patenting the obvious /
> ideas / “inventions” just in case?
> >
> > (well aware that the authors of said patent will wake up to this in a
> few hours)
> >
> > Personally, I am not comfortable with this, but maybe I am a dinosaur?
> >
> > Graeme
> >
> >> On 28 Jul 2023, at 09:13, Tim Gruene  wrote:
> >>
> >> Hi Graeme,
> >>
> >> do you want to discuss whether obvious steps can be patented?
> >>
> >> Cheers,
> >> Tim
> >>
> >>
> >> On Fri, 28 Jul 2023 07:45:38 + "Winter, Graeme (DLSLtd,RAL,LSCI)"
> >> <6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
> >>
> >>> Interesting
> >>>
> >>> https://www.freepatentsonline.com/20230228695.pdf
> >>>
> >>> Patent for use of electron diffraction to assess ligand binding
> >>>
> >>> Stumbled across this because the patent application cites my work -
> >>> felt that this would be of interest to the community
> >>>
> >>> … discuss?
> >>>
> >>> Graeme
> >>>
> >>>
> >>
> >>
> >>
> >> --
> >> --
> >> Tim Gruene
> >> Head of the Centre for X-ray Structure Analysis
> >> Faculty of Chemistry
> >> University of Vienna
> >>
> >> Phone: +43-1-4277-70202
> >>
> >> GPG Key ID = A46BEE1A
> >>
> >> 
> >>
> >> To unsubscribe from the CCP4BB list, click the following link:
> >> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
> >>
> >> This message was issued to members of http://www.jiscmail.ac.uk/CCP4BB,
> a mailing list hosted by http://www.jiscmail.ac.uk/, terms & conditions
> are available at https://www.jiscmail.ac.uk/policyandsecurity/
> >
> >
> > --
> > This e-mail and any attachments may contain confidential, copyright and
> or privileged material, and are for the use of the intended addressee only.
> If you are not the intended addressee or an authorised recipient of the
> addressee please notify us of receipt by returning the e-mail and do not
> use, copy, retain, distribute or disclose the information in or attached to
> the e-mail.
> > Any opinions expressed within this e-mail are those of the individual
> and not necessarily of Diamond Light Source Ltd.
> > Diamond Light Source Ltd. cannot guarantee that this e-mail or any
> attachments are free from viruses and we cannot accept liability for any
> damage which you may sustain as a result of software viruses which may be
> transmitted in or with the message.
> > Diamond Light Source Limited (company no. 4375679). Registered in
> England and Wales with its registered office at Diamond House, Harwell
> Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
> >
> >
> > 
> >
> > To unsubscribe from the CCP4BB list, click the following link:
> > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
> >
> > This message was issued to members of http://www.jiscmail.ac.uk/CCP4BB,
> a mailing list hosted by http://www.jiscmail.ac.uk/, terms & conditions
> are available at https://www.jiscmail.ac.uk/policyandsecurity/
>
> -
> Randy J. Read
> Department of Haematology, University of Cambridge
> Cambridge Institute for Medical Research Tel: +44 1223 336500
> The Keith Peters Building
> Hills Road   E-mail:
> rj...@cam.ac.uk
> Cambridge CB2 0XY, U.K.
> www-struct

[ccp4bb] 4 years - Ph.D. student Fellow - Structural Glycobiology Laboratory - IBMB Barcelona, Spain

[Marcelo Guerin]

A *4 years Ph.D. position* funded by the Spanish Ministry of Science and
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Spain. The IBMB is located in the Barcelona Science Park (PCB), providing
an outstanding scientific and multidisciplinary environment and
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Structural Glycobiology laboratory investigates the structural enzymology
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The PhD project will focus on the study of the *structural determinants,
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--
Prof. Marcelo E. Guerin
Head Structural Glycobiology Laboratory
Institute of Molecular Biology of Barcelona (IBMB)
Spanish National Research Council (CSIC)
C/Baldiri Reixac, 4-8
Torre R, 3rd Floor
08028, Barcelona
Spain
E-mail: mrc...@ibmb.csic.es
Web: https://sites.google.com/site/guerinlab



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Description: Adobe PDF document

Re: [ccp4bb] Dry shipper in limbo

[David J. Schuller]

FedEx missing deadlines on "overnight" shipments is not uncommon, I advise 
everyone to ship dewars to arrive at least one extra day in advance.

Also, their online tracking page could be better. They show the original 
expected delivery time even if the shipment has already missed an intermediate 
transfer point. The delivery time does not get updated until the original 
delivery time has been passed.

The multiple lost days and the international complication are unusual details 
and I don't have any specific advice on that.

===
 All Things Serve the Beam
 ===
 David J. Schuller
 modern man in a post-modern world
 MacCHESS, Cornell University
 schul...@cornell.edu

From: CCP4 bulletin board  on behalf of Savvas Savvides 
<9d24f7f13e09-dmarc-requ...@jiscmail.ac.uk>
Sent: Friday, July 28, 2023 3:56 AM
To: CCP4BB@JISCMAIL.AC.UK 
Subject: Re: [ccp4bb] Dry shipper in limbo

Dear Kevin,

A similar incident from just two weeks ago, in Europe in our case, was resolved 
by travelling to the regional FedEx package collection/distribution center to 
recover the dry-shipper in person. This involved gaining access to the FedEx 
center and talking to the right people.

I would absolutely not wait this out because your shipment is probably 
somewhere in the corner of a distribution center used as a seat by employees 
taking a break. I can attest to the fact that they do have such corners where 
“problematic" shipments are piled up!

Despite what you were told on the phone or could deduce from any online 
tracking systems (in our case the dry-shipper was not even trackable), there is 
still a (very good) chance that your shipment might still be at a regional 
collection/distribution center.

The key is to get to any information about where this place might be, talk to 
the local people, and find out what the actual route of the shipment might have 
been after getting picked up from your lab. The routes often involve 
intermediate collection/distribution sites.

To their credit, and in contrast to the general FedEx customer service, the 
people at the regional FedEx distribution center (including the shift manager) 
were very empathic and helpful, and used means that go above and beyond SOPs to 
help. This included sharing photos of the shipment via WhatsApp with 
drivers/employees of the three previous shifts etc… Despite the volumes of work 
they handle, drivers and other courier employees actually do remember unusually 
looking shipments, such as a shipping-case containing a dry-shipper!

Best of luck and wishes,
Savvas




On 28 Jul 2023, at 08:15, Savvas Savvides  wrote:



Best wishes,
Savvas

Begin forwarded message:

From: "Dr. Kevin M Jude" mailto:kj...@stanford.edu>>
Date: 28 July 2023 at 05:16:39 CEST
To: CCP4BB@jiscmail.ac.uk
Subject: [ccp4bb] Dry shipper in limbo
Reply-To: "Dr. Kevin M Jude" mailto:kj...@stanford.edu>>


My first adventure in international crystallography is off to an inauspicious 
start. On Monday, I sent a dry shipper “overnight” from California to 
Saskatchewan, but it has been stuck in the Memphis FedEx facility for a few 
days. I’ve gotten several conflicting explanations of the status from FedEx on 
the phone, but the most likely seems that it has “pre-cleared” customs and yet 
has not yet made it to Calgary. It’s not clear whether anyone actually knows 
where the shipping case is, since I was asked to give a physical description of 
it. Is there anything else I can do from a few thousand miles away, or do I 
just have to wait this out?

--
Kevin Jude, PhD
Structural Biology Research Specialist, Garcia Lab
Howard Hughes Medical Institute
Stanford University School of Medicine
Beckman B177, 279 Campus Drive, Stanford CA 94305
Phone: (650) 723-6431



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Re: [ccp4bb] Patenting ligand binding?

[John R Helliwell]

Dear Graeme,
Yes indeed, interesting.
There are clearly aspects of microED of proteins which might be documented as 
non-obvious otherwise it wouldn’t have been a bit stuck ie without the 
widespread community take up until recent years. 
In terms of a concept patent, which this might be interpreted as, an 
interesting one in my experience was the Kodak Storage Phosphor patent which 
held up Fuji for a considerable time in its commercialisation of its image 
plates even though Fuji had several specific know how patents. 
In terms of cost of patenting, especially worldwide, this is a major stumbling 
block at least at Univ Manchester who have a keen eye for whether it might be 
deemed worth it. 
Thanks for sharing.
Greetings,
John 

Emeritus Professor John R Helliwell DSc




> On 28 Jul 2023, at 08:46, Winter, Graeme (DLSLtd,RAL,LSCI) 
> <6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
> 
>  Interesting
> 
> https://www.freepatentsonline.com/20230228695.pdf
> 
> Patent for use of electron diffraction to assess ligand binding
> 
> Stumbled across this because the patent application cites my work - felt that 
> this would be of interest to the community
> 
> … discuss?
> 
> Graeme
> 
>  
> 
> -- 
> 
> This e-mail and any attachments may contain confidential, copyright and or 
> privileged material, and are for the use of the intended addressee only. If 
> you are not the intended addressee or an authorised recipient of the 
> addressee please notify us of receipt by returning the e-mail and do not use, 
> copy, retain, distribute or disclose the information in or attached to the 
> e-mail.
> Any opinions expressed within this e-mail are those of the individual and not 
> necessarily of Diamond Light Source Ltd. 
> Diamond Light Source Ltd. cannot guarantee that this e-mail or any 
> attachments are free from viruses and we cannot accept liability for any 
> damage which you may sustain as a result of software viruses which may be 
> transmitted in or with the message.
> Diamond Light Source Limited (company no. 4375679). Registered in England and 
> Wales with its registered office at Diamond House, Harwell Science and 
> Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
>  
> 
> 
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Re: [ccp4bb] Dry shipper in limbo

[Jon Cooper]

Hello, I don't do anything MAC but maybe shipping dewars would be a good 
situation for an Apple Airtag, which I read about recently, or equivalent, if 
there are any?

Best wishes, Jon Cooper. jon.b.coo...@protonmail.com

Sent from Proton Mail mobile

 Original Message 
On 28 Jul 2023, 08:56, Savvas Savvides wrote:

> Dear Kevin,
>
> A similar incident from just two weeks ago, in Europe in our case, was 
> resolved by travelling to the regional FedEx package collection/distribution 
> center to recover the dry-shipper in person. This involved gaining access to 
> the FedEx center and talking to the right people.
>
> I would absolutely not wait this out because your shipment is probably 
> somewhere in the corner of a distribution center used as a seat by employees 
> taking a break. I can attest to the fact that they do have such corners where 
> “problematic" shipments are piled up!
>
> Despite what you were told on the phone or could deduce from any online 
> tracking systems (in our case the dry-shipper was not even trackable), there 
> is still a (very good) chance that your shipment might still be at a regional 
> collection/distribution center.
>
> The key is to get to any information about where this place might be, talk to 
> the local people, and find out what the actual route of the shipment might 
> have been after getting picked up from your lab. The routes often involve 
> intermediate collection/distribution sites.
>
> To their credit, and in contrast to the general FedEx customer service, the 
> people at the regional FedEx distribution center (including the shift 
> manager) were very empathic and helpful, and used means that go above and 
> beyond SOPs to help. This included sharing photos of the shipment via 
> WhatsApp with drivers/employees of the three previous shifts etc… Despite the 
> volumes of work they handle, drivers and other courier employees actually do 
> remember unusually looking shipments, such as a shipping-case containing a 
> dry-shipper!
>
> Best of luck and wishes,
> Savvas
>
>> On 28 Jul 2023, at 08:15, Savvas Savvides  wrote:
>>
>> Best wishes,
>> Savvas
>>
>> Begin forwarded message:
>>
>>> From:"Dr. Kevin M Jude" 
>>> Date:28 July 2023 at 05:16:39 CEST
>>> To:CCP4BB@jiscmail.ac.uk
>>> Subject:[ccp4bb] Dry shipper in limbo
>>> Reply-To:"Dr. Kevin M Jude" 
>>
>>> 
>>> My first adventure in international crystallography is off to an 
>>> inauspicious start. On Monday, I sent a dry shipper “overnight” from 
>>> California to Saskatchewan, but it has been stuck in the Memphis FedEx 
>>> facility for a few days. I’ve gotten several conflicting explanations of 
>>> the status from FedEx on the phone, but the most likely seems that it has 
>>> “pre-cleared” customs and yet has not yet made it to Calgary. It’s not 
>>> clear whether anyone actually knows where the shipping case is, since I was 
>>> asked to give a physical description of it. Is there anything else I can do 
>>> from a few thousand miles away, or do I just have to wait this out?
>>>
>>> --
>>>
>>> Kevin Jude, PhD
>>>
>>> Structural Biology Research Specialist, Garcia Lab
>>>
>>> Howard Hughes Medical Institute
>>>
>>> Stanford University School of Medicine
>>>
>>> Beckman B177, 279 Campus Drive, Stanford CA 94305
>>>
>>> Phone:[(650) 723-6431](tel:%28650%29%20723-6431)
>>>
>>> ---
>>>
>>> To unsubscribe from the CCP4BB list, click the following link:
>>> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>
> ---
>
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Re: [ccp4bb] Patenting ligand binding?

[Harry Powell]

I’m left wondering which aspects of the patent application are novel and 
haven’t already been published elsewhere in the list of references (which 
include a number of Tamir’s other papers).

Others will know - can you patent something that you have already published in 
a paper? I try to steer clear of lawyers and the law...

Harry

> On 28 Jul 2023, at 12:36, John R Helliwell  wrote:
> 
> Dear Graeme,
> Yes indeed, interesting.
> There are clearly aspects of microED of proteins which might be documented as 
> non-obvious otherwise it wouldn’t have been a bit stuck ie without the 
> widespread community take up until recent years. 
> In terms of a concept patent, which this might be interpreted as, an 
> interesting one in my experience was the Kodak Storage Phosphor patent which 
> held up Fuji for a considerable time in its commercialisation of its image 
> plates even though Fuji had several specific know how patents. 
> In terms of cost of patenting, especially worldwide, this is a major 
> stumbling block at least at Univ Manchester who have a keen eye for whether 
> it might be deemed worth it. 
> Thanks for sharing.
> Greetings,
> John 
> 
> Emeritus Professor John R Helliwell DSc
> 
> 
> 
> 
>> On 28 Jul 2023, at 08:46, Winter, Graeme (DLSLtd,RAL,LSCI) 
>> <6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
>> 
>>  Interesting
>> 
>> https://www.freepatentsonline.com/20230228695.pdf
>> 
>> Patent for use of electron diffraction to assess ligand binding
>> 
>> Stumbled across this because the patent application cites my work - felt 
>> that this would be of interest to the community
>> 
>> … discuss?
>> 
>> Graeme
>> 
>>  
>> -- 
>> 
>> This e-mail and any attachments may contain confidential, copyright and or 
>> privileged material, and are for the use of the intended addressee only. If 
>> you are not the intended addressee or an authorised recipient of the 
>> addressee please notify us of receipt by returning the e-mail and do not 
>> use, copy, retain, distribute or disclose the information in or attached to 
>> the e-mail.
>> Any opinions expressed within this e-mail are those of the individual and 
>> not necessarily of Diamond Light Source Ltd. 
>> Diamond Light Source Ltd. cannot guarantee that this e-mail or any 
>> attachments are free from viruses and we cannot accept liability for any 
>> damage which you may sustain as a result of software viruses which may be 
>> transmitted in or with the message.
>> Diamond Light Source Limited (company no. 4375679). Registered in England 
>> and Wales with its registered office at Diamond House, Harwell Science and 
>> Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
>>  
>> 
>> 
>> To unsubscribe from the CCP4BB list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>> 
> 
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
> 



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Re: [ccp4bb] Dry shipper in limbo

[Jurgen Bosch]

The AirTag is a good idea, I shall implement that. I’ve had samples stuck
from Canada to US, also in Memphis. It was just protein on dry ice but
needless to say when it arrived it was very dry but no ice.
Hopefully you will be lucky and retrieve your samples within the next 14
days.

Jürgen

__
Jürgen Bosch, PhD, MBA
Center for Global Health & Diseases
Case Western Reserve University

https://www.linkedin.com/in/jubosch/

CEO & Co-Founder at InterRayBio, LLC

On Jul 28, 2023, at 07:50, Jon Cooper <
488a26d62010-dmarc-requ...@jiscmail.ac.uk> wrote:

Hello, I don't do anything MAC but maybe shipping dewars would be a good
situation for an Apple Airtag, which I read about recently, or equivalent,
if there are any?

Best wishes, Jon Cooper. jon.b.coo...@protonmail.com

Sent from Proton Mail mobile



 Original Message 
On 28 Jul 2023, 08:56, Savvas Savvides <
9d24f7f13e09-dmarc-requ...@jiscmail.ac.uk> wrote:


Dear Kevin,

A similar incident from just two weeks ago, in Europe in our case, was
resolved by travelling to the regional FedEx package
collection/distribution center to recover the dry-shipper in person. This
involved gaining access to the FedEx center and talking to the right people.

I would absolutely not wait this out because your shipment is probably
somewhere in the corner of a distribution center used as a seat by
employees taking a break. I can attest to the fact that they do have such
corners where “problematic" shipments are piled up!

Despite what you were told on the phone or could deduce from any online
tracking systems (in our case the dry-shipper was not even trackable),
there is still a (very good) chance that your shipment might still be at a
regional collection/distribution center.

The key is to get to any information about where this place might be, talk
to the local people, and find out what the actual route of the shipment
might have been after getting picked up from your lab. The routes often
involve intermediate collection/distribution sites.

To their credit, and in contrast to the general FedEx customer service, the
people at the regional FedEx distribution center (including the shift
manager) were very empathic and helpful, and used means that go above and
beyond SOPs to help. This included sharing photos of the shipment via
WhatsApp with drivers/employees of the three previous shifts etc… Despite
the volumes of work they handle, drivers and other courier employees
actually do remember unusually looking shipments, such as a shipping-case
containing a dry-shipper!

Best of luck and wishes,
Savvas




On 28 Jul 2023, at 08:15, Savvas Savvides  wrote:



Best wishes,
Savvas

Begin forwarded message:

*From:* "Dr. Kevin M Jude" 
*Date:* 28 July 2023 at 05:16:39 CEST
*To:* CCP4BB@jiscmail.ac.uk
*Subject:* *[ccp4bb] Dry shipper in limbo*
*Reply-To:* "Dr. Kevin M Jude" 


My first adventure in international crystallography is off to an
inauspicious start. On Monday, I sent a dry shipper “overnight” from
California to Saskatchewan, but it has been stuck in the Memphis FedEx
facility for a few days. I’ve gotten several conflicting explanations of
the status from FedEx on the phone, but the most likely seems that it has
“pre-cleared” customs and yet has not yet made it to Calgary. It’s not
clear whether anyone actually knows where the shipping case is, since I was
asked to give a physical description of it. Is there anything else I can do
from a few thousand miles away, or do I just have to wait this out?

-- 
Kevin Jude, PhD
Structural Biology Research Specialist, Garcia Lab
Howard Hughes Medical Institute
Stanford University School of Medicine
Beckman B177, 279 Campus Drive, Stanford CA 94305
Phone: (650) 723-6431

--

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--

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Re: [ccp4bb] Patenting ligand binding?

[Ian Tickle]

Hi Harry

On Fri, Jul 28, 2023 at 12:54 PM Harry Powell <
193323b1e616-dmarc-requ...@jiscmail.ac.uk> wrote:

> I’m left wondering which aspects of the patent application are novel and
> haven’t already been published elsewhere in the list of references (which
> include a number of Tamir’s other papers).
>

If any of the claims are the same as or the result of changes to prior art
that could be made by a person of ordinary skill in the relevant field of
technology, then they are likely to be rejected by the patent examiner.

Others will know - can you patent something that you have already published
> in a paper? I try to steer clear of lawyers and the law...
>

It depends on the "priority date" of the filing (usually but not always the
date of first filing, but it may be the priority date of an earlier related
patent).  Any publication, including those of the applicant, that pre-date
the priority date are considered to be prior art and fair game for the
patent examiner when considering the validity of the claims.

Cheers

-- Ian


>
> Harry
>
> > On 28 Jul 2023, at 12:36, John R Helliwell 
> wrote:
> >
> > Dear Graeme,
> > Yes indeed, interesting.
> > There are clearly aspects of microED of proteins which might be
> documented as non-obvious otherwise it wouldn’t have been a bit stuck ie
> without the widespread community take up until recent years.
> > In terms of a concept patent, which this might be interpreted as, an
> interesting one in my experience was the Kodak Storage Phosphor patent
> which held up Fuji for a considerable time in its commercialisation of its
> image plates even though Fuji had several specific know how patents.
> > In terms of cost of patenting, especially worldwide, this is a major
> stumbling block at least at Univ Manchester who have a keen eye for whether
> it might be deemed worth it.
> > Thanks for sharing.
> > Greetings,
> > John
> >
> > Emeritus Professor John R Helliwell DSc
> >
> >
> >
> >
> >> On 28 Jul 2023, at 08:46, Winter, Graeme (DLSLtd,RAL,LSCI) <
> 6a19cead4548-dmarc-requ...@jiscmail.ac.uk> wrote:
> >>
> >>  Interesting
> >>
> >> https://www.freepatentsonline.com/20230228695.pdf
> >>
> >> Patent for use of electron diffraction to assess ligand binding
> >>
> >> Stumbled across this because the patent application cites my work -
> felt that this would be of interest to the community
> >>
> >> … discuss?
> >>
> >> Graeme
> >>
> >>
> >> --
> >>
> >> This e-mail and any attachments may contain confidential, copyright and
> or privileged material, and are for the use of the intended addressee only.
> If you are not the intended addressee or an authorised recipient of the
> addressee please notify us of receipt by returning the e-mail and do not
> use, copy, retain, distribute or disclose the information in or attached to
> the e-mail.
> >> Any opinions expressed within this e-mail are those of the individual
> and not necessarily of Diamond Light Source Ltd.
> >> Diamond Light Source Ltd. cannot guarantee that this e-mail or any
> attachments are free from viruses and we cannot accept liability for any
> damage which you may sustain as a result of software viruses which may be
> transmitted in or with the message.
> >> Diamond Light Source Limited (company no. 4375679). Registered in
> England and Wales with its registered office at Diamond House, Harwell
> Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
> >>
> >>
> >>
> >> To unsubscribe from the CCP4BB list, click the following link:
> >> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
> >>
> >
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> > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
> >
>
> 
>
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[ccp4bb] Macs, XQuartz, ccp4i2, Coot, iMosflm....

[Harry Powell]

Hi folks

I note that the installation pages for ccp4i2 tell me that I need _exactly_ 
version 2.8.0 of XQuartz so that things like Coot, iMosflm, etc will work. The 
problem with that is that my TrueType fonts seem to have disappeared from 
XEmacs and I’m left with the spidery bit-mapped fonts (I installed XQuartz 
2.8.0 - 2021-03-21 - First release with native Apple Silicon support, which is 
one the many “exactly 2.8.0” available).

Are there any cures for this (I’m actually running on an Intel box, not Apple 
Silicon) that let me continue to run my choice of tools “ancient and modern” 
with a pleasing appearance?

Harry



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[ccp4bb] Call open for beamtime at XALOC (ALBA synchrotron) in 2024, deadline 4th September

[Roeland Boer]

Dear fellow crystallographers,

I would like to draw your attention to the call  for proposals for the 
XALOC beamline at the ALBA synchrotron, open until the 4th of September 
2023. The call is for experiments to be performed during the whole year 
of 2024.


Some features of XALOC:

 * Recently updated detector to a Pilatus 3X (100 Hz) 6M
 * Remote data collection supported, dewar shipment reimbursed for EU
   member countries
 * Supports SPINE (8 xtals/h) and Unipuck (12 xtals/h)
 * Tunable from 5-20 keV, SAD and MAD capabilities
 * Flux at 12.662 keV is 2E12 ph/s, and 3E11 ph/s at 6 keV
 * Automated MR
 * Software: MxCube and EXI (default data processing with XIA2,
   AutoPROC and EDNAProc)
 o Continuous raster scans
 o Helical data collection
 * Plate diffraction experiments supported

Please also note that SSX is now a reality at XALOC. If you are 
interested in more details, please contact XALOC Staff.


Please visit https://www.cells.es/en/users/call-information

To submit a proposal, visit https://useroffice.cells.es/

Best regards,

Roeland Boer.



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Re: [ccp4bb] Patenting ligand binding?

[Dale Tronrud]

   There are certainly a large number of bad patents being issued, 
particularly in the US.  The patent office here seems to have decided 
that it is easier (for them) to just approve most every application and 
let the courts filter out the bad ones, which requires years of work for 
lawyers and boatloads of money.  There is a serious need for reform of 
the process.


   On the other hand, my experience with the technology transfer people 
at the University of Oregon (when I used to work there) is that they, 
(and most universities) are very careful to ensure the proposed patent's 
utility and validity when making an application because the cost of 
filing is quite high relative to their budget.


   The patent application in the current discussion begins with a 
detailed description of techniques that we all have used for many years 
and are obvious to us.  This description, however, is just the 
introduction to the patent and not a listing of the methods being 
patented.  The first section just gives the context in which the methods 
should be considered.


   On page 7 there is the section "DETAILED DESCRIPTION OF THE 
INVENTION" and that description is "A method for soaking ligands into 
macromolecule (e.g. protein) crystals (e.g. microcrystals) on EM (e.g. 
TEM) grids is presented. One or more crystals on the grid are soaked 
simultaneously using standard cryo-EM vitrification equipment."  So, the 
only claim of novelty is for soaking in the ligand in a specific way 
after the crystals are placed on the grid.  I'm not qualified to say if 
this is actually novel and unobvious, but the application seems to me to 
be very narrow and specific and NOT a blanket claim of performing 
structural biology using electron scattering.


Dale Tronrud

On 7/28/2023 12:45 AM, Winter, Graeme (DLSLtd,RAL,LSCI) wrote:

Interesting

https://www.freepatentsonline.com/20230228695.pdf 



Patent for use of electron diffraction to assess ligand binding

Stumbled across this because the patent application cites my work - felt 
that this would be of interest to the community


… discuss?

Graeme

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do not use, copy, retain, distribute or disclose the information in or 
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and not necessarily of Diamond Light Source Ltd.
Diamond Light Source Ltd. cannot guarantee that this e-mail or any 
attachments are free from viruses and we cannot accept liability for any 
damage which you may sustain as a result of software viruses which may 
be transmitted in or with the message.
Diamond Light Source Limited (company no. 4375679). Registered in 
England and Wales with its registered office at Diamond House, Harwell 
Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom





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Re: [ccp4bb] Patenting ligand binding?

[Patrick Shaw Stewart]

>
> "A method for soaking ligands into
> macromolecule (e.g. protein) crystals (e.g. microcrystals) on EM (e.g.
> TEM) grids is presented. One or more crystals on the grid are soaked
> simultaneously using standard cryo-EM vitrification equipment."  So, the
> only claim of novelty is for soaking in the ligand in a specific way
> after the crystals are placed on the grid.


The things to read are the claims (below).  In fact, patent agents
sometimes put misleading or vague blurb into the abstract and description
to confuse competitors (I'm told)

The first claim is the important one.  The others are there in case they
have to fall back onto them because the first claim is overruled by prior
art.  This patent is about introducing small molecules into crystals *on a
grid.  *I'm guessing that they may need to fall back onto at least claim 4,
which is about blotting - in other words, this isn't much of an invention!

__

What is claimed is:

l. A method of introducing a small molecule into a crystal of a
macromolecule, comprising applying a first sample comprising the crystal of
the macromolecule onto an electron microscopy (EM) grid; and contacting the
crystal with a second sample comprising the small molecule to introduce the
small molecule into the crystal.

2.   The method of claim l, wherein the EM grid has a carbon side
and a copper side, and wherein both said applying the first sample and said
contacting with the second sample are on the carbon side.

3.   The method of claim 2, lilrther comprising blotting the EM
grid from the copper side alter applying said first sample but before
contacting with said second sample.

4.   The method of claim 2 or 3, further comprising blotting the EM
grid from the copper side after contacting with said second sample.

5.   The method of any one of claims 1 to 4, further comprising
plunging the EM grid into a cryogenic liquid.

The method of claim 5, wherein the cryogenic liquid is liquid ethane


On Fri, Jul 28, 2023 at 7:07 PM Dale Tronrud  wrote:

> There are certainly a large number of bad patents being issued,
> particularly in the US.  The patent office here seems to have decided
> that it is easier (for them) to just approve most every application and
> let the courts filter out the bad ones, which requires years of work for
> lawyers and boatloads of money.  There is a serious need for reform of
> the process.
>
> On the other hand, my experience with the technology transfer people
> at the University of Oregon (when I used to work there) is that they,
> (and most universities) are very careful to ensure the proposed patent's
> utility and validity when making an application because the cost of
> filing is quite high relative to their budget.
>
> The patent application in the current discussion begins with a
> detailed description of techniques that we all have used for many years
> and are obvious to us.  This description, however, is just the
> introduction to the patent and not a listing of the methods being
> patented.  The first section just gives the context in which the methods
> should be considered.
>
> On page 7 there is the section "DETAILED DESCRIPTION OF THE
> INVENTION" and that description is "A method for soaking ligands into
> macromolecule (e.g. protein) crystals (e.g. microcrystals) on EM (e.g.
> TEM) grids is presented. One or more crystals on the grid are soaked
> simultaneously using standard cryo-EM vitrification equipment."  So, the
> only claim of novelty is for soaking in the ligand in a specific way
> after the crystals are placed on the grid.  I'm not qualified to say if
> this is actually novel and unobvious, but the application seems to me to
> be very narrow and specific and NOT a blanket claim of performing
> structural biology using electron scattering.
>
> Dale Tronrud
>
> On 7/28/2023 12:45 AM, Winter, Graeme (DLSLtd,RAL,LSCI) wrote:
> > Interesting
> >
> > https://www.freepatentsonline.com/20230228695.pdf
> > 
> >
> > Patent for use of electron diffraction to assess ligand binding
> >
> > Stumbled across this because the patent application cites my work - felt
> > that this would be of interest to the community
> >
> > … discuss?
> >
> > Graeme
> >
> > --
> >
> > This e-mail and any attachments may contain confidential, copyright and
> > or privileged material, and are for the use of the intended addressee
> > only. If you are not the intended addressee or an authorised recipient
> > of the addressee please notify us of receipt by returning the e-mail and
> > do not use, copy, retain, distribute or disclose the information in or
> > attached to the e-mail.
> > Any opinions expressed within this e-mail are those of the individual
> > and not necessarily of Diamond Light Source Ltd.
> > Diamond Light Source Ltd. cannot guarantee that this e-mail or any
> > attachments are free from viruses an

Re: [ccp4bb] Dry shipper in limbo

[Lari Lehtiö]

Dear all,

Just a note as we have been experimenting with this lately after some lost 
shipments.

We went with Lightbug pro and are ordering more of those.
https://lightbug.io/product/pro/

One can customize it to send updates only when moving out of the premises or 
geofence to significantly lower the costs of updates and there is an API one 
can use for integration. It is also not limited to Apple ecosystem as we do not 
need to have an iDevice to connect to it and there does not need to be an 
iPhone in the storage facility where the lost dewar is. We aim to add a dewar 
management and tracking system to the IceBear we use to track crystallization, 
crystals and data  (this feature not yet available) and that is also why these 
features are rather important for us.
https://icebear.fi/

This is just one possibility but based on the testing we have been happy with 
this solution. And of course, since we started using it, the couriers have not 
lost any dry shippers.

Best wishes,

Lari


__
Lari Lehtiö, Professor
Faculty of Biochemistry and Molecular Medicine
P.O.Box 5400
FIN-90014 University of Oulu
Finland
https://www.oulu.fi/en/research-groups/lari-lehtio-structural-and-chemical-biology-adp-ribosylation
https://twitter.com/LabLehtio
_


From: CCP4 bulletin board  on behalf of Jurgen Bosch 

Sent: Friday, July 28, 2023 3:34 PM
To: CCP4BB@JISCMAIL.AC.UK 
Subject: Re: [ccp4bb] Dry shipper in limbo

The AirTag is a good idea, I shall implement that. I’ve had samples stuck from 
Canada to US, also in Memphis. It was just protein on dry ice but needless to 
say when it arrived it was very dry but no ice.
Hopefully you will be lucky and retrieve your samples within the next 14 days.

Jürgen

__
Jürgen Bosch, PhD, MBA
Center for Global Health & Diseases
Case Western Reserve University

https://www.linkedin.com/in/jubosch/

CEO & Co-Founder at InterRayBio, LLC

On Jul 28, 2023, at 07:50, Jon Cooper 
<488a26d62010-dmarc-requ...@jiscmail.ac.uk>
 wrote:

Hello, I don't do anything MAC but maybe shipping dewars would be a good 
situation for an Apple Airtag, which I read about recently, or equivalent, if 
there are any?

Best wishes, Jon Cooper. 
jon.b.coo...@protonmail.com

Sent from Proton Mail mobile



 Original Message 
On 28 Jul 2023, 08:56, Savvas Savvides < 
9d24f7f13e09-dmarc-requ...@jiscmail.ac.uk>
 wrote:

Dear Kevin,

A similar incident from just two weeks ago, in Europe in our case, was resolved 
by travelling to the regional FedEx package collection/distribution center to 
recover the dry-shipper in person. This involved gaining access to the FedEx 
center and talking to the right people.

I would absolutely not wait this out because your shipment is probably 
somewhere in the corner of a distribution center used as a seat by employees 
taking a break. I can attest to the fact that they do have such corners where 
“problematic" shipments are piled up!

Despite what you were told on the phone or could deduce from any online 
tracking systems (in our case the dry-shipper was not even trackable), there is 
still a (very good) chance that your shipment might still be at a regional 
collection/distribution center.

The key is to get to any information about where this place might be, talk to 
the local people, and find out what the actual route of the shipment might have 
been after getting picked up from your lab. The routes often involve 
intermediate collection/distribution sites.

To their credit, and in contrast to the general FedEx customer service, the 
people at the regional FedEx distribution center (including the shift manager) 
were very empathic and helpful, and used means that go above and beyond SOPs to 
help. This included sharing photos of the shipment via WhatsApp with 
drivers/employees of the three previous shifts etc… Despite the volumes of work 
they handle, drivers and other courier employees actually do remember unusually 
looking shipments, such as a shipping-case containing a dry-shipper!

Best of luck and wishes,
Savvas




On 28 Jul 2023, at 08:15, Savvas Savvides  wrote:



Best wishes,
Savvas

Begin forwarded message:

From: "Dr. Kevin M Jude" mailto:kj...@stanford.edu>>
Date: 28 July 2023 at 05:16:39 CEST
To: CCP4BB@jiscmail.ac.uk
Subject: [ccp4bb] Dry shipper in limbo
Reply-To: "Dr. Kevin M Jude" mailto:kj...@stanford.edu>>


My first adventure in international crystallography is off to an inauspicious 
start. On Monday, I sent a dry shipper “overnight” from California to 
Saskatchewan, but it has been stuck in the Memphis FedEx facility for a few 
days. I’ve gotten several conflicting explanations of the 

Re: [ccp4bb] Dry shipper in limbo

[Dr. Kevin M Jude]

Hi all, thanks for the responses on and off list.

Yesterday I got my case assigned to someone in the international shipping 
division, gave a physical description of my shipping case and expressed the 
perishable nature of the contents. My dewar turned up in Calgary last night and 
was just delivered to CLS, hopefully in cold condition. My contact at CLS was 
able to give my time (yesterday) to another user and get me rescheduled for the 
weekend. I had shipped Monday for Thursday beamtime, hoping to avoid limbo over 
the weekend, but maybe in the future I’ll aim a little earlier.

Besides the on-list responses, I had a couple of helpful off-list replies:

BW duct-tapes an airtag into his shipping cases to help keep an eye on them

SG says be sure to include USCMA/CUSMA certificate of origin for shipments 
within North America, along with statement that the samples are non-hazardous, 
for research purposes, with no commercial value (and don’t assign a high value 
to the shipment). When contacting FedEx ask for a supervisor in the 
international shipping division. Customs inspectors may be less tied up late at 
night.


From: CCP4 bulletin board  on behalf of Dr. Kevin M Jude 

Date: Thursday, July 27, 2023 at 8:16 PM
To: CCP4BB@JISCMAIL.AC.UK 
Subject: [ccp4bb] Dry shipper in limbo
My first adventure in international crystallography is off to an inauspicious 
start. On Monday, I sent a dry shipper “overnight” from California to 
Saskatchewan, but it has been stuck in the Memphis FedEx facility for a few 
days. I’ve gotten several conflicting explanations of the status from FedEx on 
the phone, but the most likely seems that it has “pre-cleared” customs and yet 
has not yet made it to Calgary. It’s not clear whether anyone actually knows 
where the shipping case is, since I was asked to give a physical description of 
it. Is there anything else I can do from a few thousand miles away, or do I 
just have to wait this out?

--
Kevin Jude, PhD
Structural Biology Research Specialist, Garcia Lab
Howard Hughes Medical Institute
Stanford University School of Medicine
Beckman B177, 279 Campus Drive, Stanford CA 94305
Phone: (650) 723-6431



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[ccp4bb] Deadline approaching! Instruct-ERIC Soft X-ray Tomography workshop at Diamond Light Source...

[Harkiolaki, Maria (DLSLtd,RAL,LSCI)]

Hi everyone,



We are running an Instruct-ERIC Soft X-ray Tomography workshop/school at 
beamline B24 at the UK synchrotron Diamond Light Source 11th - 15th of 
September.


This is an exciting opportunity for young or experienced investigators to gain 
valuable hands-on experience with our pipeline including sample preparation 
followed by data collection on the cryo-Structured Illumination Microscope and  
cryo-Soft X-ray Transmission microscope at beamline B24.

Lectures and practicals will be delivered by leading experts in the field from 
key beamlines that offer the technique at synchrotrons such as DLS (UK), ALS & 
NSLS (USA) and Bessy II (Germany).

The course is designed for 12 onsite participants/students but all the lectures 
will be streamed on Zoom for anyone interested (you still need to register for 
that!).

The deadline for registration is this coming Monday (!) so please act quickly 
(we will likely extend it by a few days if there is enough interest).


Places are open to academic and industrial delegates, subject to application.

Go to the course event page for further information and to apply:



https://www.diamond.ac.uk/Home/Events/2023/2023-Instruct-ERIC-Soft-X-ray-Tomography-workshop-.html



Please do not hesitate to contact me or the team at beamline B24 if you have 
any questions...


All the best,


Maria


--


Prof Maria Harkiolaki, FRSB

Principal Beamline Scientist B24



Diamond Light Source

Harwell Science and Innovation Campus

Didcot OX11 0DE

United Kingdom

Tel: +44 1235 778757


https://www.linkedin.com/in/maria-harkiolaki-2b1232242/


-- 
This e-mail and any attachments may contain confidential, copyright and or 
privileged material, and are for the use of the intended addressee only. If you 
are not the intended addressee or an authorised recipient of the addressee 
please notify us of receipt by returning the e-mail and do not use, copy, 
retain, distribute or disclose the information in or attached to the e-mail.
Any opinions expressed within this e-mail are those of the individual and not 
necessarily of Diamond Light Source Ltd. 
Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments 
are free from viruses and we cannot accept liability for any damage which you 
may sustain as a result of software viruses which may be transmitted in or with 
the message.
Diamond Light Source Limited (company no. 4375679). Registered in England and 
Wales with its registered office at Diamond House, Harwell Science and 
Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom




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Re: [ccp4bb] Dry shipper in limbo

[Jan Abendroth]

Hi all,

In addition to the statements above, our experience has shown that using
the Customs broker as described on the CLS webpage has been helpful. Our
weekly shipments from Seattle to Saskatoon typically make it overnight,
worst case the next day.
Also, test your dewars. They should keep cold for a good week. With simple
tests one can identify dewars that are on their way out.
Glad that your dewar turned up and that the great staff at CLS could fit
you in.

Cheers,
Jan

On Fri, Jul 28, 2023 at 1:09 PM Dr. Kevin M Jude  wrote:

> Hi all, thanks for the responses on and off list.
>
>
>
> Yesterday I got my case assigned to someone in the international shipping
> division, gave a physical description of my shipping case and expressed the
> perishable nature of the contents. My dewar turned up in Calgary last night
> and was just delivered to CLS, hopefully in cold condition. My contact at
> CLS was able to give my time (yesterday) to another user and get me
> rescheduled for the weekend. I had shipped Monday for Thursday beamtime,
> hoping to avoid limbo over the weekend, but maybe in the future I’ll aim a
> little earlier.
>
>
>
> Besides the on-list responses, I had a couple of helpful off-list replies:
>
>
>
> BW duct-tapes an airtag into his shipping cases to help keep an eye on them
>
>
>
> SG says be sure to include USCMA/CUSMA certificate of origin for shipments
> within North America, along with statement that the samples are
> non-hazardous, for research purposes, with no commercial value (and don’t
> assign a high value to the shipment). When contacting FedEx ask for a
> supervisor in the international shipping division. Customs inspectors may
> be less tied up late at night.
>
>
>
>
>
> *From: *CCP4 bulletin board  on behalf of Dr.
> Kevin M Jude 
> *Date: *Thursday, July 27, 2023 at 8:16 PM
> *To: *CCP4BB@JISCMAIL.AC.UK 
> *Subject: *[ccp4bb] Dry shipper in limbo
>
> My first adventure in international crystallography is off to an
> inauspicious start. On Monday, I sent a dry shipper “overnight” from
> California to Saskatchewan, but it has been stuck in the Memphis FedEx
> facility for a few days. I’ve gotten several conflicting explanations of
> the status from FedEx on the phone, but the most likely seems that it has
> “pre-cleared” customs and yet has not yet made it to Calgary. It’s not
> clear whether anyone actually knows where the shipping case is, since I was
> asked to give a physical description of it. Is there anything else I can do
> from a few thousand miles away, or do I just have to wait this out?
>
>
>
> --
>
> Kevin Jude, PhD
>
> Structural Biology Research Specialist, Garcia Lab
>
> Howard Hughes Medical Institute
>
> Stanford University School of Medicine
>
> Beckman B177, 279 Campus Drive, Stanford CA 94305
>
> Phone: (650) 723-6431
>
>
> --
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>
> --
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>


-- 
Jan Abendroth
UCB BioSciences
Seattle / Bainbridge Island, WA, USA
home: jan.abendr...@gmail.com
work: jan.abendr...@ucb.com



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Re: [ccp4bb] Dry shipper in limbo

[Debanu Das]

Hi Jan, Kevin,

Our experience shipping from San Francisco to CLS has ranged from arrival
on 2nd day to 10th day (both extreme), most commonly on 3rd or 4th day,
irrespective of using the CLS recommended customs broker or FedEx as the
international broker. The main parameter is likely if the package goes
directly to Calgary or is routed via Memphis, and this is dependent on
FedEx operational logistics and not something that can be selected or
planned for.

It's possible that Seattle to Saskatoon is always routed directly, making
it consistently an overnight delivery. Luckily with our 2 local SF Bay Area
synchrotrons that I've been using regularly for about 20 years, we only
ship elsewhere sporadically.

The top of the line dewars in best condition are rated up to around 14 days
I think, and we have personally tested it up to 10 days without any issues,
although typically I would want to restrict them to ~7 days as dry
shippers.

Typically, in my experience, if there are sudden untraceable/no information
status updates on FedEx due to their logistics/missed connection, usually
they show up on the system again in 1-2 days as the package works through
their delayed delivery/shipping process.

Best,
Debanu

On Fri, Jul 28, 2023 at 6:30 PM Jan Abendroth 
wrote:

> Hi all,
>
> In addition to the statements above, our experience has shown that using
> the Customs broker as described on the CLS webpage has been helpful. Our
> weekly shipments from Seattle to Saskatoon typically make it overnight,
> worst case the next day.
> Also, test your dewars. They should keep cold for a good week. With simple
> tests one can identify dewars that are on their way out.
> Glad that your dewar turned up and that the great staff at CLS could fit
> you in.
>
> Cheers,
> Jan
>
> On Fri, Jul 28, 2023 at 1:09 PM Dr. Kevin M Jude 
> wrote:
>
>> Hi all, thanks for the responses on and off list.
>>
>>
>>
>> Yesterday I got my case assigned to someone in the international shipping
>> division, gave a physical description of my shipping case and expressed the
>> perishable nature of the contents. My dewar turned up in Calgary last night
>> and was just delivered to CLS, hopefully in cold condition. My contact at
>> CLS was able to give my time (yesterday) to another user and get me
>> rescheduled for the weekend. I had shipped Monday for Thursday beamtime,
>> hoping to avoid limbo over the weekend, but maybe in the future I’ll aim a
>> little earlier.
>>
>>
>>
>> Besides the on-list responses, I had a couple of helpful off-list replies:
>>
>>
>>
>> BW duct-tapes an airtag into his shipping cases to help keep an eye on
>> them
>>
>>
>>
>> SG says be sure to include USCMA/CUSMA certificate of origin for
>> shipments within North America, along with statement that the samples are
>> non-hazardous, for research purposes, with no commercial value (and don’t
>> assign a high value to the shipment). When contacting FedEx ask for a
>> supervisor in the international shipping division. Customs inspectors may
>> be less tied up late at night.
>>
>>
>>
>>
>>
>> *From: *CCP4 bulletin board  on behalf of Dr.
>> Kevin M Jude 
>> *Date: *Thursday, July 27, 2023 at 8:16 PM
>> *To: *CCP4BB@JISCMAIL.AC.UK 
>> *Subject: *[ccp4bb] Dry shipper in limbo
>>
>> My first adventure in international crystallography is off to an
>> inauspicious start. On Monday, I sent a dry shipper “overnight” from
>> California to Saskatchewan, but it has been stuck in the Memphis FedEx
>> facility for a few days. I’ve gotten several conflicting explanations of
>> the status from FedEx on the phone, but the most likely seems that it has
>> “pre-cleared” customs and yet has not yet made it to Calgary. It’s not
>> clear whether anyone actually knows where the shipping case is, since I was
>> asked to give a physical description of it. Is there anything else I can do
>> from a few thousand miles away, or do I just have to wait this out?
>>
>>
>>
>> --
>>
>> Kevin Jude, PhD
>>
>> Structural Biology Research Specialist, Garcia Lab
>>
>> Howard Hughes Medical Institute
>>
>> Stanford University School of Medicine
>>
>> Beckman B177, 279 Campus Drive, Stanford CA 94305
>>
>> Phone: (650) 723-6431
>>
>>
>> --
>>
>> To unsubscribe from the CCP4BB list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>>
>> --
>>
>> To unsubscribe from the CCP4BB list, click the following link:
>> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>>
>
>
> --
> Jan Abendroth
> UCB BioSciences
> Seattle / Bainbridge Island, WA, USA
> home: jan.abendr...@gmail.com
> work: jan.abendr...@ucb.com
>
> --
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1
>



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