Anybody tried to cocrystallize the protein-progesterone or estrogen complexes, if so how do you go about the solubility of these compounds? Progesterone is only soluble in 50% chloroform or 100% DMSO and the dilution of this stock is not possible as chloroform falls out of solution. Lots of papers out there used soaking with progesterone or expressed the protein in the presence of progesterone. Any suggestions would be appreciated.Thanks
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