Here's something that I'm currently trying out: make a list of mail user 
agents which are unlikely to be used for spam, and lower the hits for mail 
that matches.  Here's what I currently have:

header NON_SPAM_MAILER_1        X-Mailer =~ 
/(?:CWMail|Edsamail|eGroups|KMail|MailCity|MIME-tools|Mozilla|Eudora|Yahoo|Evolution|Internet
 
Mail Service|SquirrelMail|Apple Mail|Excite|exmh|Lotus 
Notes|Opera|Z-Mail|fastmail|Perl|Emacs)/
describe NON_SPAM_MAILER_1      User agent not one often used for spamming

header NON_SPAM_MAILER_2        User-Agent =~ 
/(?:Mutt|Mozilla|Emacs|eGroups|Microsoft-Entourage|SavvySubmit)/
describe NON_SPAM_MAILER_1      User agent not one often used for spamming

score NON_SPAM_MAILER_1        -10.0
score NON_SPAM_MAILER_2        -10.0

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