Re: [R] Use of R in clinical trials

http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ucm071072.htm Tho only software "products" explicitely mentioned in this documents are ... WinBUGS, BRugs and OpenB

Re: [R] Use of R in clinical trials

Le samedi 20 février 2010 à 09:44 -0800, Dieter Menne a écrit : > If you check > > http://n4.nabble.com/R-help-f789696.html > > you will note that this thread has the largest number of read since years. > Looks like an encouragement to Mark to keep the mentioned CRAN document > updated. > > To a

Re: [R] Use of R in clinical trials

Richland Statistics > 9800 North 24th St > Richland, MI  49083 > > > > -Original Message- > >From: "Christopher W. Ryan" > >Sent: Feb 18, 2010 1:08 PM > >To: r-help@r-project.org > >Cc: p.dalga...@biostat.ku.dk > >Subject: Re: [R] Use of R in c

Re: [R] Use of R in clinical trials

Looks like my message misunderstood: I tried to explain that "assay validation" and "validation for clinical trials" are mixed up by people working mainly in clinical applications, who have to make judgments about statistical applications. There is nothing wrong in using SAS, R or Excel (wi

Re: [R] Use of R in clinical trials

If you check http://n4.nabble.com/R-help-f789696.html you will note that this thread has the largest number of read since years. Looks like an encouragement to Mark to keep the mentioned CRAN document updated. To add a more serious note to my sarcastic comments earlier: I don't think the FDA o

Re: [R] Use of R in clinical trials

: John Sorkin To: Gunter Bert Cc: Dieter Menne Cc: Sent: 2/19/2010 12:55:36 PM Subject: Re: [R] Use of R in clinical trials On Feb 19, 2010, at 6:56 AM, John Sorkin wrote: > Bert, > There is a lesson here. Just as intolerance of any statistical analysis > program (or system) other

Re: [R] Use of R in clinical trials

M To: Dieter Menne; r-help@r-project.org Subject: Re: [R] Use of R in clinical trials Bert, There is a lesson here. Just as intolerance of any statistical analysis program (or system) other than SAS should lead to our being drive crazy, so to should intolerance of any statistical analysis program (or s

Re: [R] Use of R in clinical trials

On Feb 19, 2010, at 6:56 AM, John Sorkin wrote: > Bert, > There is a lesson here. Just as intolerance of any statistical analysis > program (or system) other than SAS should lead to our being drive crazy, so > to should intolerance of > any statistical analysis program (or system) other than R.

Re: [R] Use of R in clinical trials

Bert, There is a lesson here. Just as intolerance of any statistical analysis program (or system) other than SAS should lead to our being drive crazy, so to should intolerance of any statistical analysis program (or system) other than R. John >>> Dieter Menne 2/19/2010 3:46 AM >>> Bert, I

Re: [R] Use of R in clinical trials

Bert, I like your comments. There is one issue, however, that drives me crazy whenever I meet a customer asking "You are not using SAS? Too bad, we need validated results." Bert Gunter wrote: > > ... > Also to reiterate, it's not only > statistical/reporting functionality but even more the int

Re: [R] Use of R in clinical trials

required a staff just to keep them running. Murray M Cooper, PhD Richland Statistics 9800 North 24th St Richland, MI 49083 -Original Message- >From: "Christopher W. Ryan" >Sent: Feb 18, 2010 1:08 PM >To: r-help@r-project.org >Cc: p.dalga...@biostat.ku.dk >Sub

Re: [R] Use of R in clinical trials

On Feb 18, 2010, at 4:26 PM, Christopher W. Ryan wrote: > Anyone have any recollection of Prophet software, from the National (US) > Center for Research Resources? > > --Chris A quick Google search comes up with a very dated site at Northwestern: http://www.basic.northwestern.edu/biotools/pr

Re: [R] Use of R in clinical trials

-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, February 18, 2010 12:44 PM To: Douglas Bates Cc: r-help@r-project.org; Bert Gunter Subject: Re: [R] Use of R in clinical trials (Corrections/additional information welcome!) My recollect

Re: [R] Use of R in clinical trials

es >> Cc: r-help@r-project.org; Bert Gunter >> Subject: Re: [R] Use of R in clinical trials >> >> >>>> (Corrections/additional information welcome!) >>> >>> My recollection is that the BMD programs (which, in a later version, >>> became BM

Re: [R] Use of R in clinical trials

> -Original Message- > From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On > Behalf Of Peter Dalgaard > Sent: Thursday, February 18, 2010 12:44 PM > To: Douglas Bates > Cc: r-help@r-project.org; Bert Gunter > Subject: Re: [R] Use of

Re: [R] Use of R in clinical trials

(Corrections/additional information welcome!) My recollection is that the BMD programs (which, in a later version, became BMDP) predated SAS and were specifically for BioMeDical analysis. How could I forget those! Yes, my old (as in 1980-1985) boss at the University hospital even had the

Re: [R] Use of R in clinical trials

roject.org [mailto:r-help-boun...@r-project.org] On Behalf Of Jeff Laake Sent: Thursday, February 18, 2010 11:28 AM To: r-help@r-project.org Subject: Re: [R] Use of R in clinical trials I am old enough. Memory isn't always reliable but Doug Bates recounting is what I remember and a quick

Re: [R] Use of R in clinical trials

I am old enough. Memory isn't always reliable but Doug Bates recounting is what I remember and a quick search has BMDP developed in 1961 and SAS in 1966. To my surprise, the search produced a site that offered BMDP for sale. On 2/18/2010 11:15 AM, Peter Dalgaard wrote: Christopher W. Ryan w

Re: [R] Use of R in clinical trials

: > From: Erik Iverson > Subject: Re: [R] Use of R in clinical trials > To: "Frank E Harrell Jr" > Cc: "Cody Hamilton" , r-help@r-project.org > Date: Wednesday, February 17, 2010, 9:05 PM > Frank E Harrell Jr wrote: > > Cody, > > > > How

Re: [R] Use of R in clinical trials

Christopher W. Ryan wrote: Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS and FDA) What did pharmaceutical companies use for data analysis before there was SAS? And was there much angst over the change to SAS from whatever was in use bef

Re: [R] Use of R in clinical trials

half Of Christopher W. Ryan > Sent: Thursday, February 18, 2010 10:09 AM > To: r-help@r-project.org > Cc: p.dalga...@biostat.ku.dk > Subject: Re: [R] Use of R in clinical trials > > Pure Food and Drug Act: 1906 > FDA: 1930s > founding of SAS: early 1970s > > (from the history

Re: [R] Use of R in clinical trials

On 19/02/2010, at 1:12 AM, John Sorkin wrote: > It is easy to devolve into visceral response mode, lose objectivity and slip > into intolerance. R, S, S-Plus, SAS, PASW (nee SPSS), STATA, are all tools. > Each has strengths and weaknesses. No one is inherently better, or worse than > the other

Re: [R] Use of R in clinical trials

lto:r-help-boun...@r-project.org] On Behalf Of Christopher W. Ryan Sent: Thursday, February 18, 2010 10:09 AM To: r-help@r-project.org Cc: p.dalga...@biostat.ku.dk Subject: Re: [R] Use of R in clinical trials Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history webs

Re: [R] Use of R in clinical trials

Pure Food and Drug Act: 1906 FDA: 1930s founding of SAS: early 1970s (from the history websites of SAS and FDA) What did pharmaceutical companies use for data analysis before there was SAS? And was there much angst over the change to SAS from whatever was in use before? Or was there not such

Re: [R] Use of R in clinical trials

last word. Bert Gunter Genentech Nonclinical Biostatistics -Original Message- From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Frank E Harrell Jr Sent: Thursday, February 18, 2010 6:01 AM To: bill.venab...@csiro.au Cc: r-help@r-project.org; p.dalga..

Re: [R] Use of R in clinical trials

y, February 18, 2010 6:01 AM To: bill.venab...@csiro.au Cc: r-help@r-project.org; p.dalga...@biostat.ku.dk Subject: Re: [R] Use of R in clinical trials I really like both of your responses. To add to Peter's thoughts, I've found that more than half of SAS programmers can learn modern progra

Re: [R] Use of R in clinical trials

tories > > > -Original Message- > From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On > Behalf Of Peter Dalgaard > Sent: Thursday, 18 February 2010 5:55 PM > To: Frank E Harrell Jr > Cc: r-help@r-project.org; Cody Hamilton > Subject: Re: [R

Re: [R] Use of R in clinical trials

Original Message- From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, 18 February 2010 5:55 PM To: Frank E Harrell Jr Cc: r-help@r-project.org; Cody Hamilton Subject: Re: [R] Use of R in clinical trials Frank E Harrell Jr wrote: Cody, H

Re: [R] Use of R in clinical trials

On Thu, Feb 18, 2010 at 12:12 PM, John Sorkin wrote: > It is easy to devolve into visceral response mode, lose objectivity and slip > into intolerance. R, S, S-Plus, SAS, PASW (nee SPSS), STATA, are all tools. > Each has strengths and weaknesses. No one is inherently better, or worse than > the

Re: [R] Use of R in clinical trials

ank E Harrell Jr Cc: Cody Hamilton Sent: 2/18/2010 4:29:27 AM Subject: Re: [R] Use of R in clinical trials On 2/18/10, Frank E Harrell Jr wrote: > How amazing that SAS is still used to produce reports that reviewers hate > and that requires tedious low-level programming. R + LaTeX has

Re: [R] Use of R in clinical trials

On 2/18/10, Frank E Harrell Jr wrote: > How amazing that SAS is still used to produce reports that reviewers hate > and that requires tedious low-level programming. R + LaTeX has it all over > To simplify things, R + LyX could also be a solution. Liviu __

Re: [R] Use of R in clinical trials

Venables CSIRO/CMIS Cleveland Laboratories -Original Message- From: r-help-boun...@r-project.org [mailto:r-help-boun...@r-project.org] On Behalf Of Peter Dalgaard Sent: Thursday, 18 February 2010 5:55 PM To: Frank E Harrell Jr Cc: r-help@r-project.org; Cody Hamilton Subject: Re: [R] Use of

Re: [R] Use of R in clinical trials

Frank E Harrell Jr wrote: Cody, How amazing that SAS is still used to produce reports that reviewers hate and that requires tedious low-level programming. R + LaTeX has it all over that approach IMHO. We have used that combination very successfully for several data and safety monitoring rep

Re: [R] Use of R in clinical trials

Erik Iverson wrote: Frank E Harrell Jr wrote: Cody, How amazing that SAS is still used to produce reports that reviewers hate and that requires tedious low-level programming. R + LaTeX has it all over that approach IMHO. We have used that combination very successfully for several data and

Re: [R] Use of R in clinical trials

Frank E Harrell Jr wrote: Cody, How amazing that SAS is still used to produce reports that reviewers hate and that requires tedious low-level programming. R + LaTeX has it all over that approach IMHO. We have used that combination very successfully for several data and safety monitoring rep

Re: [R] Use of R in clinical trials

Agreed. The tables in the pdf the poster at http://www.stata.com/statalist/archive/2008-01/msg00098.html links to look terrible compared to the standard I am used to from Hmisc::latex(). Just saying. -Ista On Wed, Feb 17, 2010 at 9:33 PM, Frank E Harrell Jr wrote: > Cody, > > How amazing that SA

Re: [R] Use of R in clinical trials

Cody, How amazing that SAS is still used to produce reports that reviewers hate and that requires tedious low-level programming. R + LaTeX has it all over that approach IMHO. We have used that combination very successfully for several data and safety monitoring reporting tasks for clinical

[R] Use of R in clinical trials

Dear all, There have been a variety of discussions on the R list regarding the use of R in clinical trials. The following post from the STATA list provides an interesting opinion regarding why SAS remains so popular in this arena: http://www.stata.com/statalist/archive/2008-01/msg00098.html Re