Sent: Wednesday, October 9, 2019 6:14 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Changes in quaternary structure
Dear CCP4BB subscribers,
I am writing a discussion on extensive quaternary changes between two different
homodimers of the same protein and I would like to ask you for any examples
Indeed!
Eleanor
On Wed, 9 Oct 2019 at 15:48, Tristan Croll wrote:
> For that matter, the insulin *receptor* is a spectacular example of very
> large conformational changes in a homodimer.
>
> On 2019-10-09 15:27, Eleanor Dodson wrote:
> > There are many insulin structures with domain shifts.
> >
For that matter, the insulin *receptor* is a spectacular example of very
large conformational changes in a homodimer.
On 2019-10-09 15:27, Eleanor Dodson wrote:
There are many insulin structures with domain shifts.
4ins and 1trz share sequence but have different conformations for one
of the mol
There are many insulin structures with domain shifts.
4ins and 1trz share sequence but have different conformations for one of
the molecules..
Eleanor Dodson
On Wed, 9 Oct 2019 at 14:32, Tanner, John J. wrote:
> The same enzyme adopting different quaternary structures is a form of
> allosteric
The same enzyme adopting different quaternary structures is a form of
allosteric regulation. Jaffe's group has described this phenomenon - the
“morpheein" model of allosteric regulation.
Reviews:
https://www.ncbi.nlm.nih.gov/pubmed/22182754
https://www.ncbi.nlm.nih.gov/pubmed/16023348
John J.
IV ."
> À: CCP4BB@JISCMAIL.AC.UK
> Envoyé: Mercredi 9 Octobre 2019 14:00:45
> Objet: Re: [ccp4bb] Changes in quaternary structure
> Dear Gabriela,
> while I don't have experience strictly on the same protein presenting multiple
> homodimerization modes, it might be useful to look
Dear Gabriela,
while I don't have experience strictly on the *same protein* presenting
multiple homodimerization modes, it might be useful to look into some
conserved structure families (STAR domains, PDZ domains) which are known to
form various different homodimerization modes. Perhaps some of th
Dear CCP4BB subscribers,
I am writing a discussion on extensive quaternary changes between two different
homodimers of the same protein and I would like to ask you for any examples of
your own work/that you know of to include in my analysis. Basically, any
proteins known to exist in two differe
