Dear Gabriela, We have encountered the example of the calcium-binding protein S100A6, which is known to form a canonical S100 homodimer whose quaternary structure is shared by all other members of the S100 protein family ( [ https://www.ncbi.nlm.nih.gov/pubmed/11937060 | https://www.ncbi.nlm.nih.gov/pubmed/11937060 ] ) but which displayed a distinct homodimerization mode when we crystallized it in complex with its cognate RAGE receptor ( [ https://www.ncbi.nlm.nih.gov/pubmed/27818100 | https://www.ncbi.nlm.nih.gov/pubmed/27818100 ] ). In this particular case, there was no domain reorganization within the monomers in between the 2 homodimeric states.
I don't know if this is what you're exactly looking for but I hope this helps. Laure ---------------------------- Laure YATIME, PhD, HDR Inserm CRCN Researcher Laboratory of Pathogen-Host Interactions (LPHI) UMR 5235 - University of Montpellier Place E. Bataillon - Bât. 24 cc 107 34095 - MONTPELLIER cedex 5 FRANCE Tel: +33 (0)4 67 14 92 04 E-mail: laure.yat...@umontpellier.fr laure.yat...@inserm.fr ORCID ID: [ http://orcid.org/0000-0002-3650-8012 | http://orcid.org/0000-0002-3650-8012 ] Web page: [ https://lphi.umontpellier.fr/en/le-laboratoire/trombinoscope/26-equipe-5/105-theme-2-danger-signals-and-chronic-inflammation | https://lphi.umontpellier.fr/en/le-laboratoire/trombinoscope/26-equipe-5/105-theme-2-danger-signals-and-chronic-inflammation ] > De: "EchelonIV ." <arne.raasa...@gmail.com> > À: CCP4BB@JISCMAIL.AC.UK > Envoyé: Mercredi 9 Octobre 2019 14:00:45 > Objet: Re: [ccp4bb] Changes in quaternary structure > Dear Gabriela, > while I don't have experience strictly on the same protein presenting multiple > homodimerization modes, it might be useful to look into some conserved > structure families (STAR domains, PDZ domains) which are known to form various > different homodimerization modes. Perhaps some of the references below might > be > useful: > PDZ: > [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022880/ | > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022880/ ] > [ https://www.ncbi.nlm.nih.gov/pubmed/12954649/ | > https://www.ncbi.nlm.nih.gov/pubmed/12954649/ ] > [ https://www.ncbi.nlm.nih.gov/pubmed/12493751/ | > https://www.ncbi.nlm.nih.gov/pubmed/12493751/ ] > [ https://www.ncbi.nlm.nih.gov/pubmed/17928286/ | > https://www.ncbi.nlm.nih.gov/pubmed/17928286/ ] > STAR: > [ https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26758068/ | > https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26758068/ ] > [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650229/ | > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650229/ ] > [ https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4629-x | > https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4629-x ] > Hope this helps, > Arne > -- > Arne Raasakka > PhD Biochemistry > Department of Biomedicine, University of Bergen > On Wed, Oct 9, 2019 at 1:25 PM Gabriela GARCIA RODRIGUEZ < [ > mailto:gabriela.garcia.rodrig...@vub.be | gabriela.garcia.rodrig...@vub.be ] > > wrote: >> Dear CCP4BB subscribers, >> I am writing a discussion on extensive quaternary changes between two >> different >> homodimers of the same protein and I would like to ask you for any examples >> of >> your own work/that you know of to include in my analysis. Basically, any >> proteins known to exist in two different (or more) homodimerised states >> (suffering changes in domain organisation between states would be even more >> interesting). >> I would greatly appreciate any examples! Thank you for your time and >> attention. >> Warm regards, >> Gabriela >> ____ >> Gabriela Garcia Rodriguez >> [ mailto:gabriela.garcia.rodrig...@vub.be | gabriela.garcia.rodrig...@vub.be >> ] >> PhD candidate >> Structural Biology Research Centre (SBRC) >> Vlaams Instituut voor Biotechnologie (VIB) - Vrije Universiteit Brussel (VUB) >> Pleinlaan 2- 1050 Brussels, Belgium >> To unsubscribe from the CCP4BB list, click the following link: >> [ https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 | >> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 ] > To unsubscribe from the CCP4BB list, click the following link: > [ https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 | > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 ] ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
