There are many insulin structures with domain shifts.
4ins and 1trz share sequence but have different conformations for one of
the molecules..
Eleanor Dodson


On Wed, 9 Oct 2019 at 14:32, Tanner, John J. <tanne...@missouri.edu> wrote:

> The same enzyme adopting different quaternary structures is a form of
> allosteric regulation. Jaffe's group has described this phenomenon - the
> “morpheein" model of allosteric regulation.
>
> Reviews:
> https://www.ncbi.nlm.nih.gov/pubmed/22182754
> https://www.ncbi.nlm.nih.gov/pubmed/16023348
>
>
>
> John J. Tanner, PhD
> Professor of Biochemistry and Chemistry
> Associate Chair of Biochemistry
> University of Missouri
> 117 Schweitzer Hall
> 503 S. College Avenue
> Columbia, MO 65211
> Phone: 573-884-1280
> Email: tanne...@missouri.edu
> http://faculty.missouri.edu/~tannerjj/tannergroup/tanner.html
>
>
>
>
>
> On Oct 9, 2019, at 6:14 AM, Gabriela GARCIA RODRIGUEZ <
> gabriela.garcia.rodrig...@vub.be <gabriela.garcia.rodrig...@vub.be>>
> wrote:
>
> Dear CCP4BB subscribers,
>
> I am writing a discussion on extensive quaternary changes between two
> different homodimers of the same protein and I would like to ask you for
> any examples of your own work/that you know of to include in my analysis.
> Basically, any proteins known to exist in two different (or more)
> homodimerised states (suffering changes in domain organisation between
> states would be even more interesting).
> I would greatly appreciate any examples! Thank you for your time and
> attention.
>
> Warm regards,
>
> Gabriela
> ____
>
> *Gabriela Garcia Rodriguez*
>
> *gabriela.garcia.rodrig...@vub.be <gabriela.garcia.rodrig...@vub.be>*
>
> PhD candidate
>
> Structural Biology Research Centre (SBRC)
>
> Vlaams Instituut voor Biotechnologie (VIB) - Vrije Universiteit Brussel
> (VUB)
>
> Pleinlaan 2- 1050 Brussels, Belgium
>
>
>
>
>
>
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