For that matter, the insulin *receptor* is a spectacular example of very
large conformational changes in a homodimer.
On 2019-10-09 15:27, Eleanor Dodson wrote:
There are many insulin structures with domain shifts.
4ins and 1trz share sequence but have different conformations for one
of the molecules..
Eleanor Dodson
On Wed, 9 Oct 2019 at 14:32, Tanner, John J. <tanne...@missouri.edu>
wrote:
The same enzyme adopting different quaternary structures is a form
of allosteric regulation. Jaffe's group has described this
phenomenon - the “morpheein" model of allosteric regulation.
Reviews:
https://www.ncbi.nlm.nih.gov/pubmed/22182754 [2]
https://www.ncbi.nlm.nih.gov/pubmed/16023348 [3]
John J. Tanner, PhD
Professor of Biochemistry and Chemistry
Associate Chair of Biochemistry
University of Missouri
117 Schweitzer Hall
503 S. College Avenue
Columbia, MO 65211
Phone: 573-884-1280
Email: tanne...@missouri.edu
http://faculty.missouri.edu/~tannerjj/tannergroup/tanner.html [4]
On Oct 9, 2019, at 6:14 AM, Gabriela GARCIA RODRIGUEZ
<gabriela.garcia.rodrig...@vub.be> wrote:
Dear CCP4BB subscribers,
I am writing a discussion on extensive quaternary changes between
two different homodimers of the same protein and I would like to
ask you for any examples of your own work/that you know of to
include in my analysis. Basically, any proteins known to exist in
two different (or more) homodimerised states (suffering changes in
domain organisation between states would be even more
interesting).
I would greatly appreciate any examples! Thank you for your time
and attention.
Warm regards,
Gabriela
____
GABRIELA GARCIA RODRIGUEZ
_gabriela.garcia.rodriguez@vub.be_
PhD candidate
Structural Biology Research Centre (SBRC)
Vlaams Instituut voor Biotechnologie (VIB) - Vrije Universiteit
Brussel (VUB)
Pleinlaan 2- 1050 Brussels, Belgium
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[2] https://www.ncbi.nlm.nih.gov/pubmed/22182754
[3] https://www.ncbi.nlm.nih.gov/pubmed/16023348
[4] http://faculty.missouri.edu/~tannerjj/tannergroup/tanner.html
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