I say try it out. I have a 1x10 on my hunqapillar which is mostly seeing road use these days. 42 White Industries ENO with a11-42 Sunrace cassette, though I rarely use the 42t on the rear cassette (mostly because i keep having trouble getting it to stay in that gear when climbing a hill), and I find the other 9 gears 11-36 to be plenty fine. I live in pretty hilly area with 45 minute ascents with a 4-5% grade, and do totally fine with that. It's usually only when i'm on dirt that I start to use that 42t in the rear. Never felt i wasn't fast enough on descents or flats.
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