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Hi there,

Is there a way to successfully obtain FA/MD values from the hippocampus
subfields?

Thank you,
M

On Fri, Jan 12, 2024 at 2:23 PM Douglas N. Greve <dgr...@mgh.harvard.edu>
wrote:

> I'm not sure what you mean. The subfields are an ROI-based analysis. Are
> you saying you want to do a voxel-based analysis (without reference to
> ROIs)?
>
> On 1/9/2024 12:05 PM, Mirsol Choi wrote:
>
>         External Email - Use Caution
>
> Hi there Freesurfer,
>
> I am currently using freesurfer to take DTI metrics (FA, MD) from
> hippocampal subfields.
> At this point of my exploration with freesurfer, I am able to correctly
> register the hippocampal subfields and diffusion data, and obtain my FA
> values from the subfields. However, this is at the individual subject
> level.
>
> I will eventually need to register all of my samples in the same space for
> me to do a group analysis. However I am unsure what the order of
> registration should be for this process to be feasible.
>
> Does this order seem feasible for accurate analysis?
>
> 1) recon-all all of my subjects
> 2) dt_recon all of my subjects (one of the outputs is a registration file,
> which has registered the DTI data to outputs of recon-all)
> 3) run the hippocampus segmentation command on all subjects
> (segmentHA_T1.sh) to obtain hippocampal subfield segmentation
> 4) register the segmentation file to the FA maps (output of dt_recon)
> using vol2subfield command
> 5) After creating a subfield-FA map for each subject, spatial normalize
> the samples onto the same space using *mri_vol2vol*
>
> Thank you so much for taking the time reading my question. If there is a
> different method to spatially normalizing my datasets, or if there is a
> more optimal order of registration, I'd be happy to hear from you.
>
> Thank you,
> M
>
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