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Thank you for your response.   Yes, the key question is to adjust for
interscan variability through either histogram matching or ComBat before or
after longitudinal run.

Will await to see what the longitudinal freesufer experts think.

My best
AJ


On Wed, Jul 7, 2021, 11:40 Paul Wighton <p...@corticometrics.com> wrote:

>         External Email - Use Caution
>
> Hi AJ,
>
> The longitudinal stream does not account for inter-scanner variability,
> but does reduce biases related to registering subsequent timepoints to the
> initial one.
>
> Perhaps longitudinal experts could confirm, but I would run the
> longitudinal stream, then account for scanner differences afterwards.
>
> -Paul
>
> On Sun, Jul 4, 2021 at 10:03 AM AJ <ajcns1...@gmail.com> wrote:
>
>>         External Email - Use Caution
>>
>> Hi,
>> I am running Freesurfer on longitudinal datasets all obtained on 3T
>> scanners. Unfortunately,  many of the MRIs were done on different
>> scanners,  Phillips and GE.
>> Would longitudinal pipeline help reduced scanner variability or should I
>> process crossectionally each time point separately and normalize these time
>> points with eTIV?
>>
>> Many thanks
>> AJ
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