Dear FreeSurfer users,

I am new to surface based analysis in FreeSurfer (version 6.0). My data 
consists of T1-weighted scan from normally developing youth of 8 to 21 years of 
age. I have two questions on assumptions of this analysis for pediatric data:


(a) Is "fsaverage" an appropriate common template for all subjects of ages 8 to 
21? Online tutorials suggest that fsaverage is the most commonly used template 
in FreeSurfer analyses and, furthermore, imply that FreeSurfer can be used on 
scans of normally developing children as young as five years old.

I am running analyses separately over different age groups (like ages 8 to 12,  
13 to 16, 17 to 21) to ensure robustness. However, would combining results be 
inaccurate?


(b) Previous posts in this forum and FreeSurfer documentation strongly 
recommend somehow normalizing for head size or total brain volume in models of 
ROI area/volume. Would the eTIV covariate also be appropriate for surface-based 
analysis of scans registered to fsaverage when using mri_glmfit?

To me, it appears that scans registered to fsaverage have been warped to 
Talairach space, so the whole brain adjustment has been implicitly made.


Thank you in advance for your great insights!



Best,

Chintan
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