Thank you, Doug!

One last question:
- Using which command would one construct the "?h.white -1mm surface" and
the "?h.white+30%GM surface" for visualisation purposes as in Salat  Figure
1 (
http://www.sciencedirect.com/science/article/pii/S1053811910013261?via=ihub
)?

Thank you!
Markus



2014-03-26 15:36 GMT+01:00 Douglas Greve <gr...@nmr.mgh.harvard.edu>:

>
> On 3/26/14 8:24 AM, Markus Gschwind wrote:
>
> Dear Doug and Bruce,
>
>  I have three more questions concerning 'pctsurfcon'.
>
>  1) The inner sampling distance is set to 1mm by default, but the outer
> sampling is done at a 30% of the cortical thickness. I saw that I could
> easily change the parameters or modify the script, but I wonder why this
> has been chosen like this. What was the rationale?
>
> A fixed distance of 1mm was used to help prevent the WM sample from
> projecting so far back that it samples GM "behind" it. I can't remember how
> I choose 30% (instead of 50%). I think David Salat used slightly different
> parameters in his paper.
>

>
>  2) I think it is possible to run glmfit on the ?h.w-g.pct.mgh file in
> order to get some group stats, right?
>
> Yes
>
>
>  3) Is it also possibe to run the xhemi on the w-g.pct.mgh file?
>
> Yes
> doug
>
>
>
>  Thank you so much!
> Markus
>
>
> 2014-03-24 23:51 GMT+01:00 Markus Gschwind <markus.gschw...@gmail.com>:
>
>> Whow that is great!! Thank you so much Doug, I was not aware of this!
>> That's what I needed it seems.
>> Thanks Bruce and Doug!
>> Markus
>>
>>
>>  2014-03-24 23:21 GMT+01:00 Douglas N Greve <gr...@nmr.mgh.harvard.edu>:
>>
>>
>>> you might want to look at the pctsurfcon script to see if that gets you
>>> where you want to be
>>>
>>> On 03/24/2014 06:18 PM, Bruce Fischl wrote:
>>> > it really depends on the size of the abnormality. I would guess 2 is
>>> > too big, and you want something more like 1, and sampling not averaging
>>> > On Mon, 24 Mar 2014, Markus Gschwind wrote:
>>> >
>>> >> Hi Bruce!
>>> >> Ok I see, great! Tank you!
>>> >>
>>> >> So to double check, this will be something like :
>>> >>
>>> >> mri_vol2surf \
>>> >>
>>> >>
>>> >>   --mov /mri/nu.mgz \
>>> >>   --ref /mri/nu.mgz \
>>> >>
>>> >>   --surf /surf/lh.white
>>> >>   --projdist mmdist -2 \ # for inside white
>>> >>
>>> >>
>>> >>   # --projdist mmdist 2 \ # for outside white
>>> >>   --interp trilinear \
>>> >>   --hemi lh \
>>> >>   --out lh.nu_inside_white.mgh
>>> >>
>>> >>
>>> >> I am not sure which one to use from those, as I want to compare stable
>>> >> values but distant from white.
>>> >>
>>> >>
>>> >>    --projfrac-avg min max del : average along normal
>>> >>    --projdist mmdist : distance projection along normal
>>> >>    --projdist-avg min max del : average along normal
>>> >>
>>> >> What would you recommend?
>>> >> Thank you again!
>>> >> Markus
>>> >>
>>> >>
>>> >>
>>> >>
>>> >>
>>> >>
>>> >>
>>> >> 2014-03-24 21:29 GMT+01:00 Bruce Fischl <fis...@nmr.mgh.harvard.edu>:
>>> >>       Hi Markus
>>> >>
>>> >>       I wouldn't use brainmask as it has been normalized too
>>> >>       aggressivley. Maybe the nu.mgz. Look at the difference between
>>> >>       values just outside of it and just inside of it
>>> >>
>>> >>       cheers
>>> >>       Bruce
>>> >>
>>> >>
>>> >>       On Mon, 24 Mar 2014, Markus Gschwind wrote:
>>> >>
>>> >>             Dear Bruce,
>>> >>             Thanks for the rapid answer!
>>> >>
>>> >>             Do you mean that I take the voxel values of
>>> >>             brainmask.mgz at the place where
>>> >>             the ?h.white surface passes, right?
>>> >>
>>> >>             I thought that the ?l.white surface marks the limit
>>> >>             between GM and WM as a
>>> >>             result of a binary decision.
>>> >>             I would be interested in the local certainty of this
>>> >>             decision. I thought
>>> >>             this is represented by the slope between the values
>>> >>             around 70 and those
>>> >>             >100.
>>> >>
>>> >>             Thanks again,
>>> >>             Markus
>>> >>
>>> >>
>>> >>
>>> >>
>>> >>
>>> >>
>>> >>             2014-03-24 19:26 GMT+01:00 Bruce Fischl
>>> >>             <fis...@nmr.mgh.harvard.edu>:
>>> >>                   Hi Markus
>>> >>
>>> >>                   I would think that looking at the gray/white
>>> >>             contrast across the
>>> >>                   ?h.white surface would be more informative
>>> >>
>>> >>                   cheers
>>> >>                   Bruce
>>> >>                   On Mon, 24 Mar 2014, Markus Gschwind wrote:
>>> >>
>>> >>                         Dear all,
>>> >>                         I would like to capture regions where
>>> >>             the gray
>>> >>                         matter/ white matter junction is blurred
>>> >>             in order to
>>> >>                         detect possible focal
>>> >>                         cortical dysplasias.
>>> >>
>>> >>                         As I understood the WM/GM segmentation
>>> >>             is done by
>>> >>                         the script mri_segment.
>>> >>
>>> >>                         Would it be possible detect those
>>> >>             regions where the
>>> >>                         gradient between GM and WM regions is
>>> >>             low?
>>> >>
>>> >>                         I imagined that running mri_segment
>>> >>             several times,
>>> >>                         with each time a different lower GM
>>> >>             threshold and
>>> >>                         higher WM threshold, and
>>> >>                         then calculating the diference between
>>> >>             the results,
>>> >>                         might give such information.
>>> >>
>>> >>                         I am very much interested in what you
>>> >>             think about
>>> >>                         this approach and how to do it
>>> >>             practically.
>>> >>
>>> >>                         For info here are the optional flags of
>>> >>             mri_segment:
>>> >>
>>> >>                         -slope <s>
>>> >>
>>> >>                         set the curvature slope (both n and p)
>>> >>
>>> >>                         -pslope <p>
>>> >>
>>> >>                         set the curvature pslope (default=1.0)
>>> >>
>>> >>                         -nslope <n>
>>> >>
>>> >>                         set the curvature nslope (default=1.0)
>>> >>
>>> >>                         -debug_voxel <x y z>
>>> >>
>>> >>                         set voxel for debugging
>>> >>
>>> >>                         -auto
>>> >>
>>> >>                         automatically detect class statistics
>>> >>             (default)
>>> >>
>>> >>                         -noauto
>>> >>
>>> >>                         don't automatically detect class
>>> >>             statistics
>>> >>
>>> >>                         -log
>>> >>
>>> >>                         log to ./segment.dat
>>> >>
>>> >>                         -keep
>>> >>
>>> >>                         keep wm edits. maintains all values of 0
>>> >>             and 255
>>> >>
>>> >>                         -ghi, -gray_hi <h>
>>> >>
>>> >>                         set the gray matter high limit
>>> >>             (default=100.000)
>>> >>
>>> >>                         -wlo, -wm_low <l>
>>> >>
>>> >>                         set the white matter low limit
>>> >>             (default=90.000)
>>> >>
>>> >>                         -whi, -wm_hi <h>
>>> >>
>>> >>                         set the white matter high limit
>>> >>             (default=125.000)
>>> >>
>>> >>                         -nseg <n>
>>> >>
>>> >>                         thicken the n largest thin strands
>>> >>             (default=20)
>>> >>
>>> >>                         -thicken
>>> >>
>>> >>                         toggle thickening step (default=ON)
>>> >>
>>> >>                         -fillbg
>>> >>
>>> >>                         toggle filling of the basal ganglia
>>> >>             (default=OFF)
>>> >>
>>> >>                         -fillv
>>> >>
>>> >>                         toggle filling of the ventricles
>>> >>             (default=OFF)
>>> >>
>>> >>                         -b <s>
>>> >>
>>> >>                         set blur sigma (default=0.25)
>>> >>
>>> >>                         -n <i>
>>> >>
>>> >>                         set # iterations of border
>>> >>             classification
>>> >>                         (default=1)
>>> >>
>>> >>                         -t <t>
>>> >>
>>> >>                         set limit to thin strands in mm
>>> >>             (default=4)
>>> >>
>>> >>                         -v
>>> >>
>>> >>                         verbose
>>> >>
>>> >>                         -p <p>
>>> >>
>>> >>                         set % threshold (default=0.80)
>>> >>
>>> >>                         -x <filename>
>>> >>
>>> >>                         extract options from filename
>>> >>
>>> >>                         -w <w>
>>> >>
>>> >>                         set wsize (default=11)
>>> >>
>>> >>                         -u
>>> >>
>>> >>                         usage
>>> >>
>>> >>
>>> >>
>>> >>                         Thank you very much for all comments!
>>> >>
>>> >>                         Markus
>>> >>
>>> >>
>>> >>             _______________________________________________
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>>>  --
>>> Douglas N. Greve, Ph.D.
>>> MGH-NMR Center
>>> gr...@nmr.mgh.harvard.edu
>>> Phone Number: 617-724-2358
>>> Fax: 617-726-7422
>>>
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>>
>>
>
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