Dear Doug and Bruce,

I have three more questions concerning 'pctsurfcon'.

1) The inner sampling distance is set to 1mm by default, but the outer
sampling is done at a 30% of the cortical thickness. I saw that I could
easily change the parameters or modify the script, but I wonder why this
has been chosen like this. What was the rationale?

2) I think it is possible to run glmfit on the ?h.w-g.pct.mgh file in order
to get some group stats, right?

3) Is it also possibe to run the xhemi on the w-g.pct.mgh file?

Thank you so much!
Markus


2014-03-24 23:51 GMT+01:00 Markus Gschwind <markus.gschw...@gmail.com>:

> Whow that is great!! Thank you so much Doug, I was not aware of this!
> That's what I needed it seems.
> Thanks Bruce and Doug!
> Markus
>
>
> 2014-03-24 23:21 GMT+01:00 Douglas N Greve <gr...@nmr.mgh.harvard.edu>:
>
>
>> you might want to look at the pctsurfcon script to see if that gets you
>> where you want to be
>>
>> On 03/24/2014 06:18 PM, Bruce Fischl wrote:
>> > it really depends on the size of the abnormality. I would guess 2 is
>> > too big, and you want something more like 1, and sampling not averaging
>> > On Mon, 24 Mar 2014, Markus Gschwind wrote:
>> >
>> >> Hi Bruce!
>> >> Ok I see, great! Tank you!
>> >>
>> >> So to double check, this will be something like :
>> >>
>> >> mri_vol2surf \
>> >>
>> >>
>> >>   --mov /mri/nu.mgz \
>> >>   --ref /mri/nu.mgz \
>> >>
>> >>   --surf /surf/lh.white
>> >>   --projdist mmdist -2 \ # for inside white
>> >>
>> >>
>> >>   # --projdist mmdist 2 \ # for outside white
>> >>   --interp trilinear \
>> >>   --hemi lh \
>> >>   --out lh.nu_inside_white.mgh
>> >>
>> >>
>> >> I am not sure which one to use from those, as I want to compare stable
>> >> values but distant from white.
>> >>
>> >>
>> >>    --projfrac-avg min max del : average along normal
>> >>    --projdist mmdist : distance projection along normal
>> >>    --projdist-avg min max del : average along normal
>> >>
>> >> What would you recommend?
>> >> Thank you again!
>> >> Markus
>> >>
>> >>
>> >>
>> >>
>> >>
>> >>
>> >>
>> >> 2014-03-24 21:29 GMT+01:00 Bruce Fischl <fis...@nmr.mgh.harvard.edu>:
>> >>       Hi Markus
>> >>
>> >>       I wouldn't use brainmask as it has been normalized too
>> >>       aggressivley. Maybe the nu.mgz. Look at the difference between
>> >>       values just outside of it and just inside of it
>> >>
>> >>       cheers
>> >>       Bruce
>> >>
>> >>
>> >>       On Mon, 24 Mar 2014, Markus Gschwind wrote:
>> >>
>> >>             Dear Bruce,
>> >>             Thanks for the rapid answer!
>> >>
>> >>             Do you mean that I take the voxel values of
>> >>             brainmask.mgz at the place where
>> >>             the ?h.white surface passes, right?
>> >>
>> >>             I thought that the ?l.white surface marks the limit
>> >>             between GM and WM as a
>> >>             result of a binary decision.
>> >>             I would be interested in the local certainty of this
>> >>             decision. I thought
>> >>             this is represented by the slope between the values
>> >>             around 70 and those
>> >>             >100.
>> >>
>> >>             Thanks again,
>> >>             Markus
>> >>
>> >>
>> >>
>> >>
>> >>
>> >>
>> >>             2014-03-24 19:26 GMT+01:00 Bruce Fischl
>> >>             <fis...@nmr.mgh.harvard.edu>:
>> >>                   Hi Markus
>> >>
>> >>                   I would think that looking at the gray/white
>> >>             contrast across the
>> >>                   ?h.white surface would be more informative
>> >>
>> >>                   cheers
>> >>                   Bruce
>> >>                   On Mon, 24 Mar 2014, Markus Gschwind wrote:
>> >>
>> >>                         Dear all,
>> >>                         I would like to capture regions where
>> >>             the gray
>> >>                         matter/ white matter junction is blurred
>> >>             in order to
>> >>                         detect possible focal
>> >>                         cortical dysplasias.
>> >>
>> >>                         As I understood the WM/GM segmentation
>> >>             is done by
>> >>                         the script mri_segment.
>> >>
>> >>                         Would it be possible detect those
>> >>             regions where the
>> >>                         gradient between GM and WM regions is
>> >>             low?
>> >>
>> >>                         I imagined that running mri_segment
>> >>             several times,
>> >>                         with each time a different lower GM
>> >>             threshold and
>> >>                         higher WM threshold, and
>> >>                         then calculating the diference between
>> >>             the results,
>> >>                         might give such information.
>> >>
>> >>                         I am very much interested in what you
>> >>             think about
>> >>                         this approach and how to do it
>> >>             practically.
>> >>
>> >>                         For info here are the optional flags of
>> >>             mri_segment:
>> >>
>> >>                         -slope <s>
>> >>
>> >>                         set the curvature slope (both n and p)
>> >>
>> >>                         -pslope <p>
>> >>
>> >>                         set the curvature pslope (default=1.0)
>> >>
>> >>                         -nslope <n>
>> >>
>> >>                         set the curvature nslope (default=1.0)
>> >>
>> >>                         -debug_voxel <x y z>
>> >>
>> >>                         set voxel for debugging
>> >>
>> >>                         -auto
>> >>
>> >>                         automatically detect class statistics
>> >>             (default)
>> >>
>> >>                         -noauto
>> >>
>> >>                         don't automatically detect class
>> >>             statistics
>> >>
>> >>                         -log
>> >>
>> >>                         log to ./segment.dat
>> >>
>> >>                         -keep
>> >>
>> >>                         keep wm edits. maintains all values of 0
>> >>             and 255
>> >>
>> >>                         -ghi, -gray_hi <h>
>> >>
>> >>                         set the gray matter high limit
>> >>             (default=100.000)
>> >>
>> >>                         -wlo, -wm_low <l>
>> >>
>> >>                         set the white matter low limit
>> >>             (default=90.000)
>> >>
>> >>                         -whi, -wm_hi <h>
>> >>
>> >>                         set the white matter high limit
>> >>             (default=125.000)
>> >>
>> >>                         -nseg <n>
>> >>
>> >>                         thicken the n largest thin strands
>> >>             (default=20)
>> >>
>> >>                         -thicken
>> >>
>> >>                         toggle thickening step (default=ON)
>> >>
>> >>                         -fillbg
>> >>
>> >>                         toggle filling of the basal ganglia
>> >>             (default=OFF)
>> >>
>> >>                         -fillv
>> >>
>> >>                         toggle filling of the ventricles
>> >>             (default=OFF)
>> >>
>> >>                         -b <s>
>> >>
>> >>                         set blur sigma (default=0.25)
>> >>
>> >>                         -n <i>
>> >>
>> >>                         set # iterations of border
>> >>             classification
>> >>                         (default=1)
>> >>
>> >>                         -t <t>
>> >>
>> >>                         set limit to thin strands in mm
>> >>             (default=4)
>> >>
>> >>                         -v
>> >>
>> >>                         verbose
>> >>
>> >>                         -p <p>
>> >>
>> >>                         set % threshold (default=0.80)
>> >>
>> >>                         -x <filename>
>> >>
>> >>                         extract options from filename
>> >>
>> >>                         -w <w>
>> >>
>> >>                         set wsize (default=11)
>> >>
>> >>                         -u
>> >>
>> >>                         usage
>> >>
>> >>
>> >>
>> >>                         Thank you very much for all comments!
>> >>
>> >>                         Markus
>> >>
>> >>
>> >>             _______________________________________________
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>> >>
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>> --
>> Douglas N. Greve, Ph.D.
>> MGH-NMR Center
>> gr...@nmr.mgh.harvard.edu
>> Phone Number: 617-724-2358
>> Fax: 617-726-7422
>>
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