Hi Martin,

If you could make available that lme toolbox link, that would be great!
Thanks for the help.

Cheers,
Harry
________________________________
From: jorge luis [jbernal0...@yahoo.es]
Sent: Tuesday, 16 October 2012 8:16 AM
To: Martin Reuter; Harry Hallock [hhal5...@uni.sydney.edu.au]
Cc: freesurfer@nmr.mgh.harvard.edu
Subject: Mixed-effects models for longitudinal data analysis in Freesurfer

Hi Harry

As Martin said, longitudinal linear mixed-effects models (lme) are the 
recommended tool for analyzing longitudinal data obtained from the Freesurfer 
longitudinal image processing pipeline. The increase in power can be dramatic. 
Coming up there is a paper about this subject. We are working on making our lme 
tools available and easy to use but in the mean time, if you are interested, I 
can make available a link for you to download our Matlab-based lme toolbox.

Best
-Jorge


________________________________
De: Martin Reuter <mreu...@nmr.mgh.harvard.edu>
Para: Harry Hallock <hhal5...@uni.sydney.edu.au>; Douglas N Greve 
<gr...@nmr.mgh.harvard.edu>; "freesurfer@nmr.mgh.harvard.edu" 
<freesurfer@nmr.mgh.harvard.edu>
Enviado: Domingo 14 de octubre de 2012 21:06
Asunto: Re: [Freesurfer] 3 Factor glm group analysis

Hi Harry.

I have some scripts to compute a slope into the time thickness or volume 
(linear fits) and then run a standard glm on that .

However, we recommend to run a linear mixed effects model (external software). 
We are working on making that available.

Best Martin

Harry Hallock <hhal5...@uni.sydney.edu.au> wrote:

Thanks Doug!

If i wanted to add a third time-point, what would u suggest would be a good 
method to use for time x group interaction?

Harry
________________________________

From: freesurfer-boun...@nmr.mgh.harvard.edu 
[freesurfer-boun...@nmr.mgh.harvard.edu] on behalf of Douglas N Greve 
[gr...@nmr.mgh.harvard.edu]
Sent: Wednesday, 10 October 2012 1:10 AM
To: freesurfer@nmr.mgh.harvard.edu
Subject: Re: [Freesurfer] 3 Factor glm group analysis

Hi Harry, I would do a time1-time2 subtraction (fscalc) and then do a 2
group analysis (search for "paired" on our wiki).
doug



On 10/09/2012 12:45 AM, hhal5...@uni.sydney.edu.au wrote:
Hello,

We are currently doing a longitudinal Group
 Analysis using
FreeSurfer,
and were wondering if there is a way to run a 3 factor design (time is
2 levels, group is 2 levels, subject is 10 levels) using the
mri_glmfit model, as i want to test the time by group interaction? Is
there a way of writing this model in an FSDG file? If we can't do this
using mri_glmfit, is it possible to do this using QDEC?

Regards,
Harry




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