Hello Freesurfers, We are interested in comparing cortical thickness in 2 groups. Due to small sample size (and thus less power), we are swaying away from whole-brain vertex analyses. Instead we would like to compare specific ROIs between two groups. We understand that we can get an estimate of average cortical thickness from each ROI. We fear that by comparing those estimates over a large ROI may cause it to be less sensitive in picking up a very small region of severe cortical thinning.
Therefore, our questions are as follows: 1. Can we perform vertex-by-vertex analyses between groups but not on whole-brain and only on the specific apriori ROIs? 2. If we can do vertex-by-vertex ROI analyses, is there a reasonable statistical method to correct for multiple comparisons? Kindly advise! Regards, Manish Dalwani Sr. PRA Dept. of Psychiatry University of Colorado Denver Tel: 303-724-3185 Email: manish.dalw...@ucdenver.edu
_______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
