1. Yes. 2. Ignore everything outside of the ROI and do a bonferroni correction by the # of vertices in the ROI.
cheers Bruce On Thu, 24 Mar 2011, Dalwani, Manish wrote: > Hello Freesurfers, > > We are interested in comparing cortical thickness in 2 groups. Due to small > sample size (and thus less power), we are swaying away from whole-brain > vertex analyses. Instead we would like to compare specific ROIs between two > groups. We understand that we can get an estimate of average cortical > thickness from each ROI. We fear that by comparing those estimates over a > large ROI may cause it to be less sensitive in picking up a very small region > of severe cortical thinning. > > Therefore, our questions are as follows: > > 1. Can we perform vertex-by-vertex analyses between groups but not on > whole-brain and only on the specific apriori ROIs? > 2. If we can do vertex-by-vertex ROI analyses, is there a reasonable > statistical method to correct for multiple comparisons? > > Kindly advise! > > Regards, > Manish Dalwani > Sr. PRA > Dept. of Psychiatry > University of Colorado Denver > Tel: 303-724-3185 > Email: manish.dalw...@ucdenver.edu > _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
