Thank you for the quick response.  If you do a partial volume correction, I 
would think the volumes from freesurfer would be less than simply counting all 
voxels, but it seems to be the opposite.  Any thoughts?

----- Original Message -----
From: Bruce Fischl <fis...@nmr.mgh.harvard.edu>
Date: Monday, February 15, 2010 10:42 am
Subject: Re: [Freesurfer] Subcortical Volume Calculation
To: Hui J Yu <h...@ic.sunysb.edu>
Cc: freesurfer@nmr.mgh.harvard.edu

> yes, we do a partial volume correction of the volumes, 
> accounting for the fraction of the structure in each border voxel.
> 
> cheers
> Bruce
> On Mon, 15 Feb 2010, Hui J Yu wrote:
> 
> >Dear Freesurfer users,
> >
> >I am wondering how are the volumes calculated from stats such 
> aseg.stat.  When I export the aseg and do a voxel count and 
> multiple the volume per voxel, my total volume is different from 
> that is given by the stats.  For example, the hippocampal 
> volume given by aseg.stats for one of my controls is 4000 cm3, 
> but when I export the aseg.mgz into matlab and do a voxel count 
> (my original voxel volume is 1mm3 isotropic) for that labeled 
> mask, the total volume is aorund 3000 cm3.  Does freesurfer 
> does some sort of intensity normalization or partial volume 
> correction?  Even if so, the magnitude of difference is 
> large that I am puzzled.
> >
> >Thank you very much.
> >
> >
> >
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