structure, and refined simultaneously, the phase information is combined
naturally, without having to export part of
the information through Hendrickson-Lattman coefficients.
I am very happy to see that phenix and phaser have adopted and are
promoting using the SAD function. Although, I must say that I am a bit
surprised, as when we were first discussing the merits of combining all
the information in this way, we found rather strong resistance:
http://www.iucr.org/news/newsletter/volume-14/number-1/congress-and-general-assembly
"R. Read and G. Bricogne (UK) suggested that the anomalous phasing
information was well described by Hendrickson Lattman coefficients..."
Refmac does have the ability to output likelihood difference maps: we are
all thankful for Gerard for introducing this powerful technique. In
future versions of CCP4 and Refmac this will be automated.
