RE: [NMusers] Reducing ETAs actually decreased OFV

2013-08-11 Thread Eleveld, DJ
You mean you removed an eta and the objective function went down? I dont think this can really happen in a straightforward way. In NONMEM, the minimum of the objective function is found and if having all etas to zero gives a lower objective function than some other eta values then barring coverg

Re: [NMusers] Reducing ETAs actually decreased OFV

2013-08-11 Thread Leonid Gibiansky
Xinting, Try to start from the initial conditions of your "reduced" model but add that "reduced" ETA with the corresponding OMEGA equal to 0.01 or other small number. If the control stream code is correct, the objective function should decrease or retain the same value. Leonid ---