You mean you removed an eta and the objective function went down? I dont think this can really happen in a straightforward way. In NONMEM, the minimum of the objective function is found and if having all etas to zero gives a lower objective function than some other eta values then barring covergence problems all zero etas should have been found.
warm regards, Douglas Eleveld ________________________________________ From: owner-nmus...@globomaxnm.com [owner-nmus...@globomaxnm.com] on behalf of Xinting Wang [wxinting1...@gmail.com] Sent: Sunday, August 11, 2013 4:23 AM To: nmusers@globomaxnm.com Subject: [NMusers] Reducing ETAs actually decreased OFV Dear all, Does anyone witnessed such a phenomenon in NONMEM as when you reduced an ETA, the OFV value, rather than increase, actually decreased? It's quite against intuition, as individual estimation should be better than population estimation in that particular parameter. Both models, whether having this ETA, converged very well. Best -- Xinting ________________________________ De inhoud van dit bericht is vertrouwelijk en alleen bestemd voor de geadresseerde(n). Anderen dan de geadresseerde(n) mogen geen gebruik maken van dit bericht, het niet openbaar maken of op enige wijze verspreiden of vermenigvuldigen. Het UMCG kan niet aansprakelijk gesteld worden voor een incomplete aankomst of vertraging van dit verzonden bericht. The contents of this message are confidential and only intended for the eyes of the addressee(s). Others than the addressee(s) are not allowed to use this message, to make it public or to distribute or multiply this message in any way. The UMCG cannot be held responsible for incomplete reception or delay of this transferred message.
