Xinting,
Try to start from the initial conditions of your "reduced" model but add
that "reduced" ETA with the corresponding OMEGA equal to 0.01 or other
small number. If the control stream code is correct, the objective
function should decrease or retain the same value.
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 8/10/2013 10:23 PM, Xinting Wang wrote:
Dear all,
Does anyone witnessed such a phenomenon in NONMEM as when you reduced an
ETA, the OFV value, rather than increase, actually decreased? It's quite
against intuition, as individual estimation should be better than
population estimation in that particular parameter. Both models, whether
having this ETA, converged very well.
Best
--
Xinting
