[no subject]

2009-04-13 Thread ke fang
Hi! Dear all! My samples were collected after a single intramuscular injection. One individuals provies only one tissue samples within the whole study. I found the MOFV were quite different between the MDV was used or not. In my opinion, the concentration in tissue at T0 must be 0 because of

[NMusers] Re: Imaginary concentrations

2009-04-13 Thread Nick Holford
Hi, The OFV is computed using all observations. If you imagine an observation at time 0 then it will change the OFV. So my advice is not to imagine concentrations with MDV=0 but just use the concentrations you really measured. Nick ke fang wrote: > Hi! > Dear all! > My samples were collected aft

[NMusers] RE:IMAGINARY CONCENTRATIONS

2009-04-13 Thread NIYI ADEDOKUN
Hi, The MDV=1 implies that your observation at that time point is missing. Zero is not the same as missing information and will contribute to the MOFV.Whether you treat the observation as zero (which makes sense for a non-endogenous analyte) or you exclude that (assumed) observation/t

Re: [NMusers] Re: Imaginary concentrations

2009-04-13 Thread ke fang
--- On Mon, 4/13/09, Nick Holford wrote: > From: Nick Holford > Subject: [NMusers] Re: Imaginary concentrations > To: nmusers@globomaxnm.com > Date: Monday, April 13, 2009, 11:55 PM > Hi, > > The OFV is computed using all observations. If you imagine > an > observation at time 0 then it will