Hi! Dear all! My samples were collected after a single intramuscular injection. One individuals provies only one tissue samples within the whole study. I found the MOFV were quite different between the MDV was used or not. In my opinion, the concentration in tissue at T0 must be 0 because of the intramuscular administration. So the concentration at T0 was not a real observed 0 but a assumed 0. The question was that if i treated the T0 concentration as a MDV, the MOFV was quite different from treating it as a real obesrved concentration. Whether the MDV should be used in my case? Can anyone help me with this problem? Thanks in advance! Fang Ke
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