Dear Katrin,
You still could code your model in $ERROR using TIME, as your diurnal
rhythm is proportional to baseline.
If you would like to explore indirect models, you could try the harmonic
approach as described in Chakraborty et al. 1999 -
http://europepmc.org/abstract/med/10533696; the
Hi,
From a purely technical point of view, you can use TIME in your $ERROR
record if you want to implement your drug effect as a direct effect on
top of the circadian rhythm (this type of model may or may not
appropriate, I leave you judge of that).
SinfS = ( 1 + Amplitude * sin ( (2*PI/Peri
Dear Bill, dear all
Thanks so much for your answer.
More concrete I would like to model blood pressure including a circadian
rhythm. Therefore I would like to use a sine or cosine function with T
instead of Time.
SinfS = ( 1 + Amplitude * sin ( (2*PI/Period) * (T-Phase) ) ) ; sine or
cos
