Dear Bill, dear all Thanks so much for your answer.
More concrete I would like to model blood pressure including a circadian rhythm. Therefore I would like to use a sine or cosine function with T instead of Time. SinfS = ( 1 + Amplitude * sin ( (2*PI/Period) * (T-Phase) ) ) ; sine or cosine function SBP = (SBas + SinfS) * (1-EffS) ; SBP = systolic blood pressure, SBas = Baseline systolic blood pressure, (1-EffS = effect) I could also model this effect using a turnover model and avoid this problem, but I would like to evaluate this kind of PD model (if there is any meaningful way to code). I also had the idea to code this sine function as a function of time in a compartment and rename this compartment in $Error, but I am not sure if there is any way to do this. Thanks again and best regards. Katrin Von: Denney, William S. [mailto:william.s.den...@pfizer.com] Gesendet: 27 July 2015 17:34 An: Katrin Volz <ankekatrin.v...@uni-saarland.de>; nmusers@globomaxnm.com Betreff: RE: [NMusers] Time 'T' in $Error Hi Katrin, $ERROR is executed once per data row. The time when $ERROR is run is the TIME value (the discrete times of the measurement). For this specific example, you can just use TIME. You will need to code your $DES block so that what youre wanting to integrate as a function of time is in a compartment amount (e.g. A(1)). With your example, its hard to see how T is used in the $DES, but perhaps you could share the real example to give a bit more concrete advice on how to integrate the answer into your code. Thanks, Bill From: owner-nmus...@globomaxnm.com <mailto:owner-nmus...@globomaxnm.com> [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Katrin Volz Sent: Monday, July 27, 2015 10:46 AM To: nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com> Subject: [NMusers] Time 'T' in $Error Dear NMuser, I would like to model a PD effect using a function which includes continuous time T . The PD Effect is coded in $Error. In general like this: $ERROR MyFunction = xxx + T PDEffect = Basline * MyFunction But T cannot be used in $Error. I tried to code the function with T in $DES and rename it to use it in $ERROR: $DES MyFunction = xxx + T $ERROR MyNewFunction = MyFunction PDEffect = Baseline * MyNewFunction but it didnt worked (to rename was not permitted by NONMEM). Does anyone of you has an idea how to solve this problem? Thanks and best regards. Katrin Anke-Katrin Volz PhD Student Saarland University Clinical Pharmacy Campus C2 2 | Room 0.31 D- 66123 Saarbrücken mail ankekatrin.v...@uni-saarland.de <mailto:ankekatrin.v...@uni-saarland.de> fon +49 [0]681 302 22 84 fax +49 [0]681 302 70 258 www.clinicalpharmacy.me <http://www.clinicalpharmacy.me>
