Re: [Freesurfer] TRACULA FA _Avg_Weight vs FA_Avg_Center differences and interpretation

2015-02-09 Thread Anastasia Yendiki
Hi Alexander - These measures (both averages and along-the-tract values) are extracted in each subject's native space, so inter-subject registration is not an issue in the difference that you found. I suspect it is because the along-the-tract measures are sampled at a certain number of cross-

Re: [Freesurfer] TRACULA FA _Avg_Weight vs FA_Avg_Center differences and interpretation

2015-02-09 Thread Alexander Tomyshev
Anastasia, thank you for the prompt response. It is helpful. I’ve already examined pathstats.byvoxel.txt files combining them with “-stat” command. First, I compared every voxel along the particular tract. Then I split this tract by 3 equal parts and tried to calculate between-group difference at

Re: [Freesurfer] TRACULA FA _Avg_Weight vs FA_Avg_Center differences and interpretation

2015-02-09 Thread Anastasia Yendiki
Hi Alexander - When you average over a larger region, you are potentially reducing noise but you may also potentially wash out an effect that is very localized by including more voxels where the effect is not present. That's the difference between the two measures, so they are at different po

[Freesurfer] TRACULA FA _Avg_Weight vs FA_Avg_Center differences and interpretation

2015-02-09 Thread Alexander Tomyshev
Dear Anastasia and Freesurfer team, I used TRACULA to get FA values for two groups: patients and controls. After that, I ran between group comparison and got circa >0.05 p-values for FA _Avg_Weight values BUT circa 0.001-0.005 p-values for FA_Avg_Center for the same tract. Then I ran correlation