Re: [ccp4bb] small molecule library

2009-10-28 Thread Flip Hoedemaeker
, 28 Oct 2009 01:41:22 + > From: hlsilves...@gmail.com > Subject: Re: [ccp4bb] small molecule library > To: CCP4BB@JISCMAIL.AC.UK > > You have several companies out there that sell that. > > You have > Enamine - large collection, good but$, > Maybridg

Re: [ccp4bb] small molecule library

2009-10-27 Thread Artem Evdokimov
d now be adjusted to the 21st century version: fifteen minutes online saves $5000 spent on a CRO). Artem _ From: CCP4 bulletin board [mailto:ccp...@jiscmail.ac.uk] On Behalf Of Jürgen Bosch Sent: Tuesday, October 27, 2009 10:53 PM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] small

Re: [ccp4bb] small molecule library

2009-10-27 Thread Jürgen Bosch
Hi Christopher, have a look at this paper and the references. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem (2006) vol. 49 (20) pp. 5939-46 The SEC after soaking is a bad idea, you will loose your fr

Re: [ccp4bb] small molecule library

2009-10-27 Thread Sridhar Prasad
Zenobia is a good place to look for, they can even customize it your needs. www.zenobiatherapeutics.com Sridhar > Date: Wed, 28 Oct 2009 01:41:22 + > From: hlsilves...@gmail.com > Subject: Re: [ccp4bb] small molecule library > To: CCP4BB@JISCMAIL.AC.UK > > You have

Re: [ccp4bb] small molecule library

2009-10-27 Thread Pascal Egea
I can suggest the following reading Discovering novel ligands for macromolecules uisng X-ray crystallographic screening Nienaber VL et al, Nature Biotechnology vol 18 october 2000 pp1105 -- Pascal F. Egea, PhD Assistant Professor UCLA, David Geffen School of Medicine Department of Biological Ch

Re: [ccp4bb] small molecule library

2009-10-27 Thread Hernani Silvestre
You have several companies out there that sell that. You have Enamine - large collection, good but$, Maybridge - good but Zenobia Inc - good, and not so leo On 27 Oct 2009, at 14:58, c.weinert wrote: Dear all. I am looking for a library of small (biologically relevant)

Re: [ccp4bb] small molecule library

2009-10-27 Thread Shao-Yang Ku
informahealthcare.com/doi/pdf/10.1517/17460441.1.1.1 Quoting c.weinert : Dear all. I am looking for a library of small (biologically relevant) compounds to test binding to a protein. Does somebody know, if there is a company that sells such a library for fragment based library screening?

Re: [ccp4bb] small molecule library

2009-10-27 Thread Jurgen Bosch
Try Emerald, reasonable price, nö comment. Jürgen .. Jürgen Bosch Johns Hopkins Bloomberg School of Public Health Department of Biochemistry & Molecular Biology Johns Hopkins Malaria Research Institute 615 North Wolfe Street, W8708 Baltimore, MD 21205 Phone: +1-410-614-4742 La

[ccp4bb] small molecule library

2009-10-27 Thread c.weinert
Dear all. I am looking for a library of small (biologically relevant) compounds to test binding to a protein. Does somebody know, if there is a company that sells such a library for fragment based library screening? (to a reasonable price). And does anybody has experience with screening such