That is true. The MPNN is implemented in the RFdiffusion notebook with
validation via alphafold.
On Fri, Feb 28, 2025 at 8:28 PM Jurgen Bosch wrote:
> You need Protein MPNN, otherwise you’ll just get a poly-glycine chain
>
> Jürgen
> ___
> Jürgen Bosc
RFdiffusion is a good starting point.
Best,
Abhishek
On Fri, Feb 28, 2025 at 7:47 PM careinaedgo...@yahoo.com <
02531c126adf-dmarc-requ...@jiscmail.ac.uk> wrote:
> Dear all
> This post is a bit off topic but I wonder if anyone could help direct me
> to a good tool to use for designing novel p
Hey
The method described in this reference using af2cycler that uses
AlphaFold2’s intrinsic denoising capabilities combined with Protein MPNN to
refine
seems like something you might want to read.
here is a biorixv paper-
https://www.biorxiv.org/content/10.1101/2024.11.21.624687v1.full
*Pius Padaya
You need Protein MPNN, otherwise you’ll just get a poly-glycine chain
Jürgen
___
Jürgen Bosch, PhD, MBA
Center for Global Health & Diseases
Case Western Reserve University
Cleveland, OH 44106
https://www.linkedin.com/in/jubosch/
CEO & Co-Founder at Int
Dear allThis post is a bit off topic but I wonder if anyone could help direct
me to a good tool to use for designing novel peptides with affinity for a
certain protein?Kind regards Careina
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