I am sure the problem would be not with the chip but the latest version of the
Mac OS - which may not be compatible. I can’t test because my university is one
whole operating system behind the times. One of the few occasions when what
they do actually benefits us.
Adrian
Sent from my iPhone
Usually 6+1 - or at least it was when I was in the system. You can apply for
tenure earlier. It’s the adjunct positions that have increased and are crap.
Those never tenure. In Some v fancy places - scripps is one - you are required
to find 100 pc of your salary. This is more common in med schoo
Bob and all,
This doesn’t seem to be complete - I hadn’t known of this, but it fails
at about 9 minutes in, when we are supposed to start watching a video diary? -
at least that’s how it is for me. Does anyone have another experience of it?
Adrian
> On
a possibility, if you must try, would be to look at intein-based protein
ligation. Hideo Iwai has a series of papers on this over the last 15+ years.
Adrian
On 26 Jul 2023, at 11:14, Armando Albert
mailto:xalb...@iqfr.csic.es>> wrote:
Dear all,
We are trying to characterize a protein consistin
For what it’s worth, side-by-side stereo-adjustable mirror glasses are still
available. Also ones that use prisms to achieve a similar, though not
identical, effect. I’ve bought various objects, because I *still* prefer
building in 3D. I think one understands better what one is looking at.
Ba
Yes but this is just classic side by side stereo. I had one until quite
recently. My memory of the ps300 is that it was fullscreen, not side by side
with the display synced as another poster said.
I also feel that the ps300 didn’t flicker because it was a raster display so no
matter how many l
A short-term (10 months) postdoctoral position is available in my laboratory at
the University of Helsinki. You will continue our work on understanding the
structure and effect of cancer-causing mutations in RET by combining cryoEM
with molecular dynamics (Liu et al. Unexpected structures formed
I’m hoping for a coot implementation that allows immersive stereo…
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This me
I think this is all true - and I’ve been putting things like this into my
(failing) grants - but I get the dispiriting sense that the medics think (to
borrow a line from hamlet) “the applicant doth protest too much methinks”.
Well if as per James H today ;), we deposit coordinates to 1sf, alpha
And the good thing is we won’t be needed any more! - as alphafold structures
will be just as good! ;)
Adrian
Sent from my iPhone
On 1 Apr 2023, at 18:06, Kolenko, Petr
<9d229ba2f5a3-dmarc-requ...@jiscmail.ac.uk> wrote:
Dear James,
what a great step forward! I see another point. In our p
I would add that those who insist on modelling the atoms that they can’t see
display a quasi-religious fervour about it, as if there is only one right way.
Sorry about the snark.
One example I remember from my graduate student days is this:
https://tinyurl.com/bddefd3t
where intact and truncate
Maybe simplest just to trim it back. I do worry that the presence of a wrong
conformation will lead to inaccurate vdw clashes that could negatively affect
other atoms.
Sent from my iPhone
> On 10 Mar 2023, at 18:25, Phil Jeffrey wrote:
>
> On 3/10/23 4:05 AM, Julia Griese wrote:
>> Hi all,
Me too. My uni says that a Microsoft set of addresses ended up on a spam
blacklist, which is why this happened. I suspect your institutions are also
using office365 outlook (also known as crapmail) as mail server and client
As roberto, I complain all the time to my uni about their mail and it. P
Surely in this day and age, one would just run AF2? - it’s clearly the best
homology modelling program ever, finding homologies that other programs can’t
reach. I would - we are - using it to supply another “best guess” for
difficult-to-build structures. One could even use it as an input for MR
Hi no - Mac. I’ll have a look next time it occurs.
Adrian
Sent from my iPhone
> On 9 Jul 2022, at 14:41, Paul Emsley wrote:
>
> On 09/07/2022 12:36, Goldman, Adrian wrote:
>> On a related theme, Paul, I often find that the undo button doesn’t work,
>> but I ca
On a related theme, Paul, I often find that the undo button doesn’t work, but I
can’t figure out why it sometimes does and sometimes doesn’t. Is this
something to do with how I open .pdb files - that somehow Coot can’t find the
backup files, even though they exist? What should I do to rectify
the “best” I’ve found is stereo glasses and display side-by-side stereo.
When I was a graduate student in the Steitz lab a WHILE ago, there was a frame
built that fit over the Evans and Sutherland Ps2 and PS390 monitors (I said a
while ago :)) that carried two mirrors at 45 degrees at your eye
My impression is that they haven’t published the code, and it is science by
press-release. If one of us tried it, we would - rightly - get hounded out of
time.
Adrian
On 4 Dec 2020, at 15:57, Michel Fodje
mailto:michel.fo...@lightsource.ca>> wrote:
I think the results from AlphaFold2, alth
I am looking for a research assistant to join the project. We are moving on
from structural studies of the enzyme to functional studies (such as PELDOR and
Nanion Surfer). Working with a postdoc in the lab, you will be an integral
member of my team. We are a diverse group of about 15 scientis
I find, when discussing definitions of words, it’s always good to look in the
OED (well, the SOED, I don’t have the big one). For redundant (redundancy
being defined as the state or quality of being redundant), we find:
1. Superabundant, superfluous, excessive. b. Characterised by superfluity o
I tend to agree - though I am still using a 15” machine myself - the lab has
13” machines and at their desks they have a big monitor as well.
Adrian
> On 8 Jun 2020, at 17:37, Harry Powell - CCP4BB
> <193323b1e616-dmarc-requ...@jiscmail.ac.uk> wrote:
>
> Hi
>
> I’d make the decision bas
l.
>
> Diana
>
> **
> Diana R. Tomchick
> Department of Biophysics, Rm. ND10.214A
> University of Texas Southwestern Medical Center
> 5323 Harry Hines Blvd.
> Dallas, TX 75061 USA
> 214-645-6383 (office)
>
>> On Feb 5, 2020, at
Phoebe and all,
What I heard recently (I have no idea whether it applies in this particular
case…) is that organisers of conferences/meetings often have considerable
difficulty getting women speakers in the first place - apparently 85% of the
XYs asked say “yes” and only 50% (less?) of the XXs.
The Goldman laboratory is looking for a research technician in membrane protein
purification. The job advert is at:
https://jobs.leeds.ac.uk/vacancy.aspx?ref=FBSFO1137
- and I can be contacted for further information.
Adrian Goldman
#
Hi,
There are two vacancies in my laboratory at the University of Leeds, one for a
postdoctoral associate working on integral membrane pyrophosphatases
)Vidilaseris et al., Sci Adv 5, eaav7574 (2019), Li et al., Nat Commun 7, 13596
(2016), Kellosalo et al., Science 337, 473-76 (2012).)
https:/
Hi,
I have a 3-year postdoctoral position in my laboratory at Leeds for a
structural biologist (broadly defined) to continue our work on integral
membrane pyrophosphatases (Kellosalo et al., Science, 337 p473 (2012); Li et
al., Nature Comm, 7, 13596 (2016); Vidilaseris et al., Sci Adv 5, eaav75
..and responding in the same vein:
my OED says that its etymology also comes from the Latin sulfur, sulphura in
the plural. So there is an etymological basis for the ph, even if it doesn’t
come from Greek.
Plus, since when has etymological logic has _anything_ to do with English
spelling?
Fi
The total number of electrons in the two systems is identical, so you are
looking for that extra fraction located closer to S than to P due to the change
in atomic number.
I haven’t checked but I doubt if this is easy even in ccdb, and I would be
stunned if it is possible in the pdb. There might
--Original Message-
> From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of
> Goldman, Adrian
> Sent: Thursday, January 31, 2019 8:43 AM
> To: CCP4BB@JISCMAIL.AC.UK
> Subject: Re: [ccp4bb] Is there any alternative to siliconized glass
> coverslips for crystalliz
When I was a graduate student, about 150,000 years ago, we took regular
coverslips and doused them in ?silane to make siliconised ones. You then let
them sit in a rack to dry. It was a bit tedious but not horrendously so.
After a while, I stopped doing it altogether, because IMHO it didn’t ma
I personally don’t think paying reviewers is a necessary solution, though it
would be nice- for us. The result would just be an increase in journal costs.
I think what we should do is not publish in journal families where the profit
is above 10 per cent. Elsevier is the place to start as their
I am struggling to see why one would want to apply an improper rotation, which
I thought was defined as rotation plus reflection. Det=-1. Truly bad things
happen to ones amino acids.
Unless you had the coordinates from a small mol in one chiral arrangement, and
wanted it in the other? But in t
All true, I did my undergraduate thesis (at cambridge about 10**6 years ago it
feels) on the formation of carboxylate-pairs in the gas phase…. But I agree
with the thread: there is a metal there; it’s almost certainly not Mg, but it’s
hard to say without further data whether its Mn, Fe, Cu, Zn
15 positions for PhD students in various aspects of structural and adhesion
biology for VIral and BacteRial Adhesins (ViBrANT) are available. This is an
EU ITN (innovative Training Network), with positions in both academia and
industry, and spanning all the way from Portugal to Finland, The c
@parisdescartes.fr<mailto:philippe.be...@parisdescartes.fr>,
philippe_be...@yahoo.fr<mailto:philippe_be...@yahoo.fr>
URLs: http://lcrbw.pharmacie.univ-paris5.fr/ ,
http://lcrbw.pharmacie.univ-paris5.fr/spip.php?article18
________
That’s quite something. To me, this thread raises another issue: I see a lot
of comments about extracting the last little bit from every byte of data
collected - but that’s not our main problem. Our main problem appears to be
shoddily-done refinement of data that are in fact perfectly decent (
There are 12 PhD places available as part of the EU Innovative Training Network
“RAMP” (RAtionalising Membrane Protein Crystallisation), headed by Monika Spano.
Applicants can be from anywhere in the world, but can not have worked in the
country where they want to get a PhD in the last three ye
I think it completely depends on the protein: in some proteins, they are
required for folding; in some (eg Fcs), they are not required for folding but
for function); in some, some of them are required and others not; in some they
are required _during_ folding, but afterwards they can be removed
The right people to look at for this are found in the structure prediction
community; a series of algorithms were developed to compare different
predictions of the same structure. Look for papers from about CASP-3 (John
Mount) or pick up any recent CASP and look at how they compare the differen
One could argue that this type of behaviour is worse than doping in athletics:
If you get caught doing that, you lose your medals and may be sued; if you
severely misreport data that enables you to publish “important” papers, you get
grants and may become tenured…but suffer no long term conseque
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