Dear all,
sorry, my last message contained a typo. Correct:
library(PowerTOST)
x <- 0.90
y <- 0.35
res <- as.numeric(sampleN.TOST(theta0 = x, CV = y, design = "2x2x4",
method = "central", details = FALSE,
print = FALSE)[7:8])
mesh <- 28
ys <- unique(sort(c(y, seq(y*.8, y*1.2, length.out = mesh))))
xs <- unique(sort(c(x, seq(x*0.95, 1, length.out = mesh))))
z <- matrix(nrow = length(ys), ncol = length(xs),
dimnames = list(paste0("y.", signif(ys, 5)),
paste0("x.", signif(xs, 5))))
for (i in seq_along(ys)) {
for (j in seq_along(xs)) {
z[i, j] <- suppressMessages(
power.TOST(CV = ys[i], theta0 = xs[j], design = "2x2x4",
method = "central", n = res[1]))
}
}
z <- z[nrow(z):1, ncol(z):1] # reverse rows & columns
z[paste0("y.", y), paste0("x.", x)] == res[2] # should be TRUE
contour(xs, ys, z, nlevels = 20, las = 1, labcex = 1,
xlab = "x", ylab = "y", main = paste("n =", res[1]))
abline(h = y, v = x, lty = 2)
points(x, y, col = "red", cex = 1.5)
text(x, y, labels = signif(z[paste0("y.", y), paste0("x.", x)], 6),
col = "red", adj = c(-0.1, 1.5))
Helmut
--
Ing. Helmut Schütz
BEBAC – Consultancy Services for
Bioequivalence and Bioavailability Studies
Neubaugasse 36/11
1070 Vienna, Austria
E helmut.schu...@bebac.at
W https://bebac.at/
F https://forum.bebac.at/
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