I also set tcp_windowsize = 65535 but this had no effect on the ability to
send the emails. 



Rob A wrote
> Wietse,
> 
> Thanks for your response.
> 
> I can consistently send a 1 MB attachment to a recipient with no issues,
> but consistently get "421 4.4.2 service timed out. (in reply to end of
> DATA command)" with a 3 MB attachment sent to the same recipient.
> 
> I have turned off tcp_window_scaling on my postfix server:
*
> # cat /proc/sys/net/ipv4/tcp_window_scaling
> 0
*
> 
> And tcpdump indicates no scaling is used as well:
*
> [Window size scaling factor: -2 (no window scaling used)]
*
> 
> Is there something else I should be looking at to resolve the issue?
> 
> - Rob A





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