punit jain:
>   > Don't look under the hood unless you know what you are looking at.
> 
> I agree with you Viktor but i am just trying to get a clear picture of
> postfix as a novice.
> 
> What my concern is what will happen after setting fast_flush_domains to
> relay domains  and  flushing the queue say at the time when the remote
> domain mentioned in  fast_flush_domain is slow ?

It will not make any difference at all. 

Files in the flush directory are used for "postqueue -s domain" or
"sendmail -qR domain".

> Will preemption of messages take place or will it effect the delivery
> process ?

None of the above.

Do not list local destinations in fast_flush_domains. In fact, it
is a good idea not to change parameters until you have been using
Postfix for a considerable time.

        Wietse

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