Yes, that looks right (assuming that cortisol is your first variable)
On 11/7/2023 3:49 PM, Laura Willers de Souza wrote:
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Hello FreeSurfer Developers,
Following the FSGD examples on the website, I built the following test:
Question: Is there an association between cortisol and cortical
thickness regressing out the effect of sex, age, APOE4_carrier (1=1 or
2 alleles, 0=no alleles), abeta, ptau, diagnosis (CU and CI)?
Regressors: 2 factors (sex, diagnosis) with 2 levels each, 5
covariates (age, APOE4_carrier (1=1 or 2 alleles, 0=no alleles),
abeta, ptau, cortisol) >> 24 regressors
Contrast: 0 0 0 0 0.5 -0.5 0.5 -0.5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
FSGD:
GroupDescriptorFile 1
Title CSF_semgrupos
Class MaleCU
Class MaleCI
Class FemaleCU
Class FemaleCI
Variables Cortisol Age ABETA ptau APOE4_carrier
Input 098_S_4003_I224603 MaleCI 11 81.3 741.5 22.83 1
Does this feel right to you?
I am having difficulty understanding how to construct the contrast to
answer the following question "Is the interaction between group
(CU/CI) and cortisol significant regressing out the effect of sex,
age, APOE_carrier, abeta and ptau?" It seems like the contrast would
be the same as before.. Can you guys help me with this?
Thanks in advance!
*Laura Willers de Souza *
PhD Student in Pharmacology and Therapeutics
Zimmer Lab - Federal University of Rio Grande do Sul
- Porto Alegre/RS - Brazil
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