External Email - Use Caution        

Dear Prof Greeve,

Gentle reminder for this question,
Many thanks
Best wishes
Gabriel




Le lun. 16 oct. 2023 à 09:06, gabriel robert <
gabriel.hadrien.rob...@gmail.com> a écrit :

> Dear Prof Greve,
>
> Many thanks for your reply,
> Could you please confirm also the second part of the sentence ? " [...]
> given the sample size this is likely to be marginal compared to the effect
> size and results would still be interpretable... "
> Sorry but experts are th only way to get a feeling about those analyses
> without ground truth..
> Best wishes
>
> Gabriel Robert, MD, PhD, HDR
> PU-PH, Pôle Hospitalo-Universitaire de Psychiatrie Adulte (PHUPA)
> Psychiatrie de la personne âgée
> Centre Hospitalier Guillaume Régnier, Rennes, France
> U1228, UMR 60274 IRISA, Campus Beaulieu, Rennes, France
> Google Scholar
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>
>
> Le lun. 16 oct. 2023 à 04:55, Douglas N. Greve <dgr...@mgh.harvard.edu> a
> écrit :
>
>> yes, I think so too
>>
>> On 9/19/2023 5:07 PM, gabriel robert wrote:
>>
>>         External Email - Use Caution
>> Dear experts in longitudinal neuroimaging
>>
>> We carefully read the papers about possible biases introduced by treating
>> timepoints images differently (Reuter and Fischl NI 2011, for example) to
>> estimate unbiased anatomical and functional changes of brain development in
>> healthy individuals. We took good note that treating each time point
>> independently would remove asymmetry biases at the cost of reduced power.
>>
>> In our project, we would like to analyze about 800 scans both 3DT1,
>> diffusion (FA preprocessed with fsl TBSS) and functional task BOLD at 3
>> time points (14 years-old, 19 years-old and 23 years-old).
>>
>> Each time point scans are preprocessed individually and normalized to a
>> specific group-based template at the corresponding time point (not a
>> within-subject midpoint symmetric space) and to the standard MNI space.
>>
>> Our question: We'd like to use a home-made study-specific multimodal
>> atlas to resample ROI BOLD mean contrasts and fractional anisotropy at each
>> time point but this atlas is *based on the last time point only (23
>> years-old).* Does this situation fall into the 'asymmetry-induced bias
>> in longitudinal processing' ?
>>
>> Our feeling is most probably yes but given the sample size this is likely
>> to be marginal compared to the effect size and results would still be
>> interpretable... ?
>>
>> Many thanks for time, interest and insight,
>>
>> Best wishes
>>
>> Gabriel
>>
>>
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