External Email - Use Caution Dear Prof Greve,
Many thanks for your reply, Could you please confirm also the second part of the sentence ? " [...] given the sample size this is likely to be marginal compared to the effect size and results would still be interpretable... " Sorry but experts are th only way to get a feeling about those analyses without ground truth.. Best wishes Gabriel Robert, MD, PhD, HDR PU-PH, Pôle Hospitalo-Universitaire de Psychiatrie Adulte (PHUPA) Psychiatrie de la personne âgée Centre Hospitalier Guillaume Régnier, Rennes, France U1228, UMR 60274 IRISA, Campus Beaulieu, Rennes, France Google Scholar <https://secure-web.cisco.com/1bZJ2LS7q0EnKOd5Y6TGPIX0TLmTTTO9Cw8-2vT0thu6q5stKLPdklzjO3lZs5pp7E4AyZmO_OpPLQBtzobeDjcuyACNMhqYaBTIHgVW7T5RiRF80r7hbp_WOqSw3hUOgiADSZxQaKX4QN9FXCR4VZbmgladp-kmZIwY24gVmYFYGnN3p6zyQgx6XoVycyZxTui6Z9flF_TRq1PDcAUqdWlMEkVtTR6bo7HtaD-R4a5jef4zkwX04rlWdcYqqe-UFUcc--3-JKf1odAUYa_TtEe3hapo65SxJjGbRVnvUENEOhtgrbNknrOn4Al6-94CDO9ELn-zByz6J6UFbG-aw7w/https%3A%2F%2Fscholar.google.fr%2Fcitations%3Fuser%3DYKM-owQAAAAJ%26hl%3Dfr> Journées de Psychiatrie de la Personne âgée <https://secure-web.cisco.com/1kQxaeFEDTXddoUz9wy2tdevxSiRc61QALHpBrStXNp6bOnR-YlgC5i1Mu9tVdA9UxLL5Bu5Sy9c0jPQIKrcWu-kQAtHM23NeDrWuWrp-FMWc41FcRjZ2ok2NoVwbRyfmzHoxB-V_OJZQEl3Rrspn4xDUsBU9mcaGdzDqFTGMp4tk2j7fm_LS4e-GjzMKtY_Gwp0kFJxoQXl06ogLv5mdZMY05PJS85wvJX6K8bpshKeXV0QEoWVHnJ3ixSt_Qjq4pPFX-I2m0LT9sUs4FVUsU9CpnzIq-3lZr1KHLgRkhVcjUmEf9a7cuKNEDS4NjhHV/https%3A%2F%2Fcongresfrancaispsychiatrie.org%2Finscription-4eme-journee-de-psychiatrie-de-la-personne-agee-jppa%2F> Société de Psychogériatrie et de Psychiatrie de la Personne Âgée (SF3PA) <https://secure-web.cisco.com/1B27Etws1yYrmcxxKIyu1GVYH5giQgbkKzUmwAHFcRqFUFIS1ymoeKNs-72SXmHBQw9OaQK0QzWxZEDIyZvYk1jbl3oaL7nzVNQb_imrpehGUY3xkeaMoap2_MH2bQoIotTCclL5DVPo-zF1-nnNP_5bD-cYxKY2YxdGA1Z1OZ_4B08pi6grGcg_E0s26Y_eDBUwnojrIn9nu-RzcjjBvZO3Rn1Td0cVe_jY7DHLYZ5n2I78oIIs7NuUiVZsQraycH23BQPS2WJVb5QQgeP8excEOoKrj_l-p_ZbYmtJJiVWARkKcSPrNREFuv8nCq96U/https%3A%2F%2Fsf3pa.com%2F> Institut de Neuroscience Clinique de Rennes <https://secure-web.cisco.com/15_wCly8ngjWiGbLJbYb3ZZ1muKGQVh2ofwvy-s29znLhdr5QV3kKOkgBAWqnpkEqMRIpQcSzOs4vzyKIncUFCVKsQt4XsP4m-WBs35MjTi12_RPEuKc2-WYRUK1-PtQXdrFJteVfCaBYUUsMAPxqDqi7Jmli2b1tbAxYqJBvuJlFolw3kFZxxXIP8_GTj8XOR5ynN5GzwNlyKzFJLcoU7lblhsaDOOoBj_YfbM8F0VC40wxQCLEfrdVqx9BpftyROWkX6CYKirDa6Dw-6Az72NRDdhiCITOLe5e9iifHvW4yCclcMX5wy5L9VA3KKRR9/https%3A%2F%2Fwww.incr.fr%2F> Le lun. 16 oct. 2023 à 04:55, Douglas N. Greve <dgr...@mgh.harvard.edu> a écrit : > yes, I think so too > > On 9/19/2023 5:07 PM, gabriel robert wrote: > > External Email - Use Caution > Dear experts in longitudinal neuroimaging > > We carefully read the papers about possible biases introduced by treating > timepoints images differently (Reuter and Fischl NI 2011, for example) to > estimate unbiased anatomical and functional changes of brain development in > healthy individuals. We took good note that treating each time point > independently would remove asymmetry biases at the cost of reduced power. > > In our project, we would like to analyze about 800 scans both 3DT1, > diffusion (FA preprocessed with fsl TBSS) and functional task BOLD at 3 > time points (14 years-old, 19 years-old and 23 years-old). > > Each time point scans are preprocessed individually and normalized to a > specific group-based template at the corresponding time point (not a > within-subject midpoint symmetric space) and to the standard MNI space. > > Our question: We'd like to use a home-made study-specific multimodal atlas > to resample ROI BOLD mean contrasts and fractional anisotropy at each time > point but this atlas is *based on the last time point only (23 > years-old).* Does this situation fall into the 'asymmetry-induced bias in > longitudinal processing' ? > > Our feeling is most probably yes but given the sample size this is likely > to be marginal compared to the effect size and results would still be > interpretable... ? > > Many thanks for time, interest and insight, > > Best wishes > > Gabriel > > > _______________________________________________ > Freesurfer mailing > listfreesur...@nmr.mgh.harvard.eduhttps://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer > > > _______________________________________________ > Freesurfer mailing list > Freesurfer@nmr.mgh.harvard.edu > https://secure-web.cisco.com/1XCQL2qmHES2c7hFG38YxlAojLMK_J7Ha89hu69Sy1dWjFWjrtXgXVM9Z2T1-vqmPt-PE5D23zY8h35cfsO2OY6A880FVPLF9RbvVsjGdgoQTS14wheNOkFWL29cSGrkvPzl7xYp0Q8g1deOf9OFytDIjxqQUdgqFUYDJNNUoqwtDOgSRRD6kr7JS5KBpEVv8GWCN3y4bJ03KTl5HOs4WhCAyqSo_qaRlH5pY0IRIy6yz_gSuiLrAkZygPfOxXA_Tu1hd9iiQQecg0KLwFtW2-GFTi_G8QSWGyBIVsp41BrzdO91hL6vR13xJMXMnYuZvt_-wsoPfbkzvwUJhScJWaw/https%3A%2F%2Fmail.nmr.mgh.harvard.edu%2Fmailman%2Flistinfo%2Ffreesurfer > The information in this e-mail is intended only for the person to whom it > is addressed. 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