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This is not something we have typically done with T1w/T2w myelin mapping.  Is 
there a reason you are especially concerned about these issues?  We tend to 
find that issues with surface placement, which are more prevalent at 1mm 
isotropic than at higher resolutions, are a far bigger issue and I don’t know 
that PETsurfer will help with this because it is based on the surfaces 
themselves.  I would recommend just sticking with the default HCP Pipelines 
approach for T1w/T2w myelin mapping.

Matt.

From: <freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Marina Fernández 
<marina.fdez.alva...@gmail.com>
Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Date: Tuesday, May 24, 2022 at 10:54 AM
To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] Tissue fraction effects correction



        External Email - Use Caution
Dear FS experts,

We are planning to correct for tissue fraction effects on T1w/T2w ratio
images using PETsurfer, setting the point spread function estimate to
zero. My questions are:

1. Does it make sense to correct for tissue fraction effects on T1w/T2w
ratio images even when T1w and T2w images were acquired using the same
matrix size with identical voxel resolution (i.e., 1mm3)?

2. If that makes sense, which PVC method would work best for correcting
tissue fraction effects (i.e., SGTM, MG, RBV) on structural MRI scans?

Many thanks in advance.

Best,
Marina

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