In this case, the paired-t is identical to RM 2x2 ANOVA. But to answer your question, the first example you give is the right way to handle it.

On 11/5/2020 4:32 AM, Agurne Sampedro Calvete wrote:

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Dear Freesurfer experts,

I am trying to do a longitudinal repeated measures ANOVA 2x2, with two groups (experimental vs control) and two time points (pre and post treatment).

Although I have run a paired t-test, now I would like to do a repeated measures anova 2x2, since I am doing the same analyses with other data in other softwares.

I am trying to follow the tutorial *MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be* https://surfer.nmr.mgh.harvard.edu/fswiki/RepeatedMeasuresAnova <https://secure-web.cisco.com/1xcEvqAuPN3MsqK1JjC6qoZbooZS3kpB4WEU1Lx8hK28grFkOWFgj7ja5TXppcZRh8Vr2s3TJyQKT-sr-c0qt4XJSU7f74cElgVAI4K1nOBI5i5L0YQBzYutTVn-MwCGM_OotAt9VM1mzmm1MUuXbYtZC4-QfIujBH30LAwD5RtwZ6vGRv4JC7ocISixV0s52BsCadrLE2J-3CdqLLZnJRA/https%3A%2F%2Fsurfer.nmr.mgh.harvard.edu%2Ffswiki%2FRepeatedMeasuresAnova>, but I have several doubts when designing the FSGD file as well as the contrasts.

How should it be the FSGD file?

I have seen in a previous post the following design for the same number fo groups and time points:

GroupDescriptorFile 1

Class Subject1

Class Subject2

Variables                                             Tp1vsTp2.GrExp    Tp1vsTp2.GrControl

Input   Subject1_time1  Subject1         1                                 0

Input   Subject1_time2  Subject1        -1                                0

Input   Subject2_time1  Subject2 0                                 1

Input   Subject2_time2  Subject02       0                                 -1

Design matrix:

1 0 1 0

1 0 -1 0

0 1 0 1

0 1 0 -1


Contrasts (.mtx files):
Tp1vsTp2.GrExp        0 0 1 0
Tp1vsTp2.GrControl  0 0 0 -1
Interaction 0 0 1 -1

Would this design be the correct one to use in this case?

Alternatively, could it be this the correct one?

GroupDescriptorFile 1

Class Subject1

Class Subject2

Variables                                             Tp1vsTp2          Groupxtime

Input  Subject1_time1  Subject1     1                                1

Input  Subject1_time2  Subject1 -1 *-1*

Input   Subject2_time1  Subject2   1 *-1*

Input  Subject2_time2  Subject02  -1                              1

Design matrix:

1 0  1 1

1 0 -1 -1

0 1  1 -1

0 1  -1 1

Contrasts (.mtx files):

Tp1vsTp2 0 0 1 0

Groupxtime Interaction   0 0 0 1


Thank you very much in advance.

Kind regards,

Agurne

Neuropsychology of Severe Medical Conditions Research Team

Dpt of Methods and Experimental Psychology
Faculty of Psychology and Education

University of Deusto

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