External Email - Use Caution        

thank you for your detailed and helpful explanation.

question 3: I mean just left and right. But what should I do if I want to
consider subcortical as well as left and right?

Best Regards
Hengameh

On Thu, Mar 12, 2020 at 12:07 AM Douglas N. Greve <dgr...@mgh.harvard.edu>
wrote:

>
>
> On 3/11/2020 4:21 PM, Hengameh Marzbani wrote:
>
>         External Email - Use Caution
>
> Thank you for the quick response.
>
> question 1: I need the results of mri-glmfit (before doing mri-glmfit-sim). I 
> can see the clusters by tksurfer. But, Can I have a text file included all 
> clusters?
>
> You can, the easiest way is to run mri_glmfit-sim and it will give you a
> list of clusters in a text file. If you set the cwp to 1, then it will give
> you all the clusters. See the help.
>
> question 3: I want to do the analyse by considering the whole brain. Is 
> correct to use --2spaces? and also I I want to visualize the results in both 
> hemisphere simultaneously. is it possible by freeview?
>
> Whole brain meaning left, right, and subcort or just left and right? If
> just left and right, then use --2spaces
>
> question 5: I can't understand what is the reason of using demean and 
> normalize. Would you mind explaining to me? And when is it necessary to use 
> them?
>
> Demeaning makes the design matrix better conditioned. But also if you are
> looking at the difference in average thickness between two groups
> regressing out, eg, age, then simply using age as a regressor will reduce
> the efficiency of the estimation because the age itself will have a
> non-zero mean, so the regression is left trying to figure out what part of
> the thickness average is due to the group and what part is due to age.
>
> Thank you so much.
>
> Hengameh
>
>
> On Tue, Mar 10, 2020 at 2:03 AM Douglas N. Greve <dgr...@mgh.harvard.edu>
> wrote:
>
>>
>>
>> On 3/9/20 5:53 PM, Hengameh Marzbani wrote:
>> >
>> >         External Email - Use Caution
>> >
>> > Hello Freesurfer developers,
>> > 1- I want to extract the uncorrected clusters from the uncorrected
>> significance maps obtained from mri_glmfit for structural data (to
>> illustrate cluster, size, location, and significance) like
>> abs.sig.cluster.summary (summary of clusters (text))which is obtained from
>> mri_glmfit-sim. Is there a way to do this?
>> Set the clusterwise p-value thresh to 1 (--cwp 1)
>> > 2- I don't see any clusters when I use cluster-based correction for
>> multiple comparisons (for example mri_glmfit-sim \  --glmdir lh.Area.glmdir
>> \ --sim mc-z 10000 2 mc-z.abs\ --sim-sign abs --cache 4 neg \  --cwp
>> 0.05\  --2spaces). How much is it significant if I report the uncorrected
>> clusters?
>> Usually, reveiewers won't let you report exclusivly uncorrected results.
>> > 3- Are there new ways of looking at the whole brain together (not left
>> and right hemisphere separately)by Qdec and FSGD?
>> You can load both hemispheres into freeview, if that is what you mean
>> > 4- How can I do fdr correction in mri_glmfit-sim? what flag should I
>> use?
>> You can't, use mri_fdr. Run with --help to get docs
>> > 5- How can I demean and normalize the covariates when I use FSGD? what
>> flag should I use?
>> Add these lines in your FSGD file
>> DeMeanFlag 1
>> ReScaleFlag 1
>> >
>> > Thanks you in advance!
>> > Best regards,
>> > Hengameh
>> >
>> >
>> >
>> >
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